Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Shock | Letter

Potential benefit of angiotensin II in COVID-19 patients: beyond reasonable doubt?

Authors: António Tralhão, Luís Ferreira Moita, Pedro Póvoa

Published in: Critical Care | Issue 1/2020

Login to get access

Excerpt

We read with great interest the editorial by Busse et al. on the potential use of angiotensin II in the treatment of COVID-19 [1]. However, amidst the myriad of attempted interventions, some may be more reasonable than others [2]. …
Literature
1.
Busse LW, Chow JH, McCurdy MT, Khanna AK. COVID-19 and the RAAS - a potential role for angiotensin II? Crit Care. 2020;24:1–4.CrossRef
2.
3.
Kuba K, Imai Y, Rao S, Jiang C, Penninger JM. Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. J Mol Med. 2006;84:814–20.CrossRef
4.
Khan A, Benthin C, Zeno B, Albertson TE, Boyd J, Christie JD, et al. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Crit Care. 2017;21:1–9.CrossRef
5.
6.
Dial S, Nessim SJ, Kezouh A, Benisty J, Suissa S. Antihypertensive agents acting on the renin-angiotensin system and the risk of sepsis. Br J Clin Pharmacol. 2014;78(5):1151–8.CrossRef
7.
Khan A, Benthin C, Zeno B, et al. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Crit Care. 2017;21:234.CrossRef
8.
Bellomo R, Wunderink RW, Szerlip H, et al. Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock. Crit Care. 2020;24:43.CrossRef
9.
Busse LW, Albertson TE, Gong MN, et al. Outcomes in patients with acute respiratory distress syndrome receiving angiotensin II for vasodilatory shock [abstract P125]. Crit Care. 2018;22(suppl 1):82 (50).
10.
Zangrillo A, Landoni G, Beretta L, Morselli F, Serpa Neto A, Bellomo R, COVID-BioB Study Group. Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series. Crit Care. 2020;24:227.CrossRef
Metadata
Title
Potential benefit of angiotensin II in COVID-19 patients: beyond reasonable doubt?
Authors
António Tralhão
Luís Ferreira Moita
Pedro Póvoa
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03027-w

Other articles of this Issue 1/2020

Critical Care 1/2020 Go to the issue

Letter

Looking for a sepsis source

Review

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

Research Letter

Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia

Letter

Risk of harlequin syndrome during bi-femoral peripheral VA-ECMO: should we pay more attention to the watershed or try to change the venous cannulation site?

Research

Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers

Editorial

Early adoption of critical care interventions is unjustifiable without concomitant effectiveness study