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European Archives of Oto-Rhino-Laryngology

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01-02-2021 | Shingles | Miscellaneous

Cranial polyneuropathy caused by herpes zoster infection: a retrospective single-center analysis

Authors: Jure Pupić-Bakrač, Ana Pupić-Bakrač, Vedrana Terkeš, Ivan Baraka

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2021

Abstract

Purpose

Cranial polyneuropathy (CP) is a rare complication of herpes zoster (HZ) infection. This entity often produces situations of a diagnostic dilemma, as can be seen in a wide spectrum of clinical presentations. The aim of this study was to report the clinical characteristics, treatment, and outcomes of 11 patients from a single-institution experience.

Methods

A retrospective analysis of patients treated for HZ CP over a 12-year period was performed.

Results

The present study included 11 patients with CP caused by HZ infection—7 (63.63%) females, and 4 (36.36%) males. The mean age at presentation was 63 years (range, 38–85 years). Cranial nerve VII was affected in nine (81.82%) cases, CN VIII in six (54.55%) cases, CN V in five (45.45%) cases, CN III and IX in two (18.18%) cases, and CN VI and X in one (9.09%) case. The treatment of choice was acyclovir in all patients, while corticosteroids were administered in six (54.55%) patients. Complete CN recovery was observed in seven (63.63%) patients, while four (36.36%) patients suffered from permanent CN damage—two (18.18%) CN VII, one (9.09%) CN VII and VIII, and one (9.09%) CN VI.

Conclusion

Herpes zoster CP presents an interesting diagnostic and therapeutic challenge. Successful management of these patients depends on a thorough knowledge of the anatomy and topodiagnostic of CNs. Early administration of antiviral agents is crucial in terms of responsiveness to treatment and expedite recovery.

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Title: Cranial polyneuropathy caused by herpes zoster infection: a retrospective single-center analysis
Authors: Jure Pupić-Bakrač
Ana Pupić-Bakrač
Vedrana Terkeš
Ivan Baraka
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Shingles
Human Alphaherpesvirus 3
Polyneuropathy
Herpes Zoster Oticus
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06279-y

At a glance: The STEP trials

Springer Medicine

Cranial polyneuropathy caused by herpes zoster infection: a retrospective single-center analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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