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Open Access 22-04-2023 | Sexually Transmitted Infection | Original Article

Proctitis in patients with monkeypox infection: a single-center analysis of 42 consecutive cases from a multidisciplinary observational study on monkeypox proctitis

Authors: J. Guevara-Martínez, F. Prieto La-Noire, P. Arteaga-Asensio, I. Pascual-Miguelañez, R. Moraes Souza, M. Quiles, M. Montes, C. Fondevila, M. Álvarez-Gallego, Monkeypox multidisciplinary collaboration group

Published in: Techniques in Coloproctology | Issue 12/2023

Abstract

Background

The current monkeypox (MP) virus outbreak was declared an international emergency in July 2022. The aim of this report is to describe our initial experience with patients with MP, focusing on proctitis.

Methods

We conducted an observational study between 20 May and 31 July 2022, on patients with MP at a reference tertiary center in Madrid, Spain. A descriptive analysis on MP was performed, focusing on its characteristics, symptoms, diagnosis, and outcomes.

Results

A total of 143 positive MP cases were diagnosed in our center; 42 of them [all male, median age 39 years (range: 22–57 years)] had proctitis (29.37%), and 3 patients (2.09%/MP total cases and 7.14%/MP proctitis) required surgical drainage of a perianal abscess.

Conclusions

General and digestive surgeons must be aware of the presence of proctological impairment and complications due to MP virus.

Harris E (2022) What to know about monkeypox. JAMA 327(23):2278–2279. https://doi.org/10.1001/jama.2022.9499CrossRefPubMed

Nakoune E, Olliaro P (2022) Waking up to monkeypox. BMJ. 25(377):o1321. https://doi.org/10.1136/bmj.o1321CrossRef

Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM (2022) NHS England high consequence infectious diseases (Airborne) network clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 22(8):1153–1162. https://doi.org/10.1016/S1473-3099(22)00228-6. (Epub 2022 May 24. Erratum in: Lancet Infect Dis. 2022 Jul;22(7):e177. Erratum in: Lancet Infect Dis. 2022 Jul;22(7):e177. PMID: 35623380; PMCID: PMC9300470)CrossRefPubMedPubMedCentral

Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V, Boesecke C, Vandekerckhove L, Yakubovsky M, Sendagorta E, Blanco JL, Florence E, Moschese D, Maltez FM, Goorhuis A, Pourcher V, Migaud P, Noe S, Pintado C, Maggi F, Hansen AE, Hoffmann C, Lezama JI, Mussini C, Cattelan A, Makofane K, Tan D, Nozza S, Nemeth J, Klein MB, Orkin CM, SHARE-net Clinical Group (2022) Monkeypox virus infection in humans across 16 countries - April-June 2022. N Engl J Med. https://doi.org/10.1056/NEJMoa2207323. (Epub ahead of print. PMID: 35866746)CrossRefPubMed

Català A, Clavo Escribano P, Riera J, Martín-Ezquerra G, Fernandez-Gonzalez P, Revelles Peñas L, Simón Gozalbo A, Rodríguez-Cuadrado FJ, Guilera Castells V, De la Torre Gomar FJ, Comunión Artieda A, Fuertes de Vega L, Blanco JL, Puig S, García Miñarro ÁM, Fiz Benito E, Muñoz-Santos C, Repiso-Jiménez JB, Ceballos-Rodriguez C, García Rodríguez V, Castaño Fernández JL, Sánchez-Gutiérrez I, Calvo López R, Berna-Rico E, de Nicolás-Ruanes B, Corella Vicente F, Tarín Vicente EJ, De Fernández Fuente L, Riera-Martí N, Descalzo-Gallego MA, Grau-Perez M, García-Doval I, Fuertes I (2022) Monkeypox outbreak in Spain: clinical and epidemiological findings in a prospective cross-sectional study of 185 cases. Br J Dermatol. https://doi.org/10.1111/bjd.21790CrossRefPubMed

Moore MJ, Rathish B, Monkeypox Zahra F (2022) In: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)

Weaver JR, Isaacs SN (2008) Monkeypox virus and insights into its immunomodulatory proteins. Immunol Rev 225:96–113. https://doi.org/10.1111/j.1600-065X.2008.00691.x. (PMID:18837778;PMCID:PMC2567051)CrossRefPubMedPubMedCentral

de Vries HJC, Nori AV, Kiellberg Larsen H, Kreuter A, Padovese V, Pallawela S, Vall-Mayans M, Ross J (2021) 2021 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. J Eur Acad Dermatol Venereol 35(7):1434–1443. https://doi.org/10.1111/jdv.17269. (Epub 2021 May 31 PMID: 34057249)CrossRefPubMed

Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D (2022) Monkeypox: a comprehensive review of transmission, pathogenesis, and manifestation. Cureus 14(7):e26531PubMedPubMedCentral

10.

Informe de situación de Monkeypox en España y otros países no endémicos 05.08.2022.

11.

https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/alertaMonkeypox/docs/Informe_de_situacion_MPX_20220805.pdf.

12.

Yakubovsky M, Shasha D, Reich S, et al. (2022) Monkeypox presenting as proctitis in men who have sex with men [published online ahead of print]. Clin Infect Dis. https://doi.org/10.1093/cid/ciac737

13.

Ramai D, Dubroff J, Walker MJ, (2022) Severe proctitis associated with monkeypox virus [published online ahead of print 2022 Nov 11]. Am J Gastroenterol. https://doi.org/10.14309/ajg.0000000000002069

14.

Bragazzi NL, Kong JD, Mahroum N, Tsigalou C, Khamisy-Farah R, Converti M, Wu J (2022) Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review. J Med Virol. https://doi.org/10.1002/jmv.27931. (Epub ahead of print. PMID: 35692117)CrossRefPubMed

15.

Martín-Delgado MC, Martín Sánchez FJ, Martínez-Sellés M, Molero García JM, Moreno Guillén S, Rodríguez-Artalejo FJ, Ruiz-Galiana J, Cantón R, De Lucas Ramos P, García-Botella A, García-Lledó A, Hernández-Sampelayo T, Gómez-Pavón J, González Del Castillo J, Muñoz P, Valerio M, Catalán P, Burillo A, Cobo A, Alcamí A, Bouza E (2022) Monkeypox in humans: a new outbreak. Rev Esp Quimioter. https://doi.org/10.3701/req/059.2022. (Epub ahead of print. PMID: 35785957)CrossRefPubMedPubMedCentral

16.

Domínguez Alvarado GA, Rativa Hernández JA, Hortua Moreno AF, et al. (2022) Monkeypox outbreak, will it affect surgery services? - Correspondence [published online ahead of print 2022 Aug 2]. Int J Surg https://doi.org/10.1016/j.ijsu.2022.106809

17.

Nörz D, Pfefferle S, Brehm TT, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp EM, Jordan S, Addo MM, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M, Knobloch JK (2022) Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox. Germany, Euro Surveill. https://doi.org/10.2807/1560-7917.ES.2022.27.26.2200477CrossRefPubMed

18.

Eloy José Tarín-Vicente, Andrea Alemany, Manuel Agud-Dios, Maria Ubals, Clara Suñer, Andrés Antón, Maider Arando, Jorge Arroyo-Andrés, Lorena Calderón-Lozano, Cristina Casañ, José Miguel Cabrera, Pep Coll, Vicente Descalzo, María Dolores Folgueira, Jorge N García-Pérez, Elena Gil-Cruz, Borja González-Rodríguez, Christian Gutiérrez-Collar, Águeda Hernández-Rodríguez, Paula López-Roa, María de los Ángeles Meléndez, Julia Montero-Menárguez, Irene Muñoz-Gallego, Sara Isabel Palencia-Pérez, Roger Paredes, Alfredo Pérez-Rivilla, María Piñana, Nuria Prat, Aída Ramirez, Ángel Rivero, Carmen Alejandra Rubio-Muñiz, Martí Vall, Kevin Stephen Acosta-Velásquez, An Wang, Cristina Galván-Casas*, Michael Marks*, Pablo L Ortiz-Romero*, Oriol Mitjà. (2022) Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study. Lancet https://doi.org/10.1016/S0140-6736(22)01436-2.

19.

Antinori A, Mazzotta V, Vita S et al. (2022) Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022. Euro Surveill 27(22):2200421. https://doi.org/10.2807/1560-7917.ES.2022.27.22.2200421CrossRefPubMedPubMedCentral

20.

Messina MD, Wolf EL, Kanmaniraja D, Alpert PL, Ricci ZJ (2022) Imaging features of anorectal proctitis in monkeypox infection. Clin Imaging 92:109–111. https://doi.org/10.1016/j.clinimag.2022.10.008CrossRefPubMedPubMedCentral

21.

Ortiz-Martínez Y, Zambrano-Sanchez G, Rodríguez-Morales AJ (2022) Monkeypox and HIV/AIDS: when the outbreak faces the epidemic. Int J STD AIDS. https://doi.org/10.1177/09564624221114191CrossRefPubMedPubMedCentral

22.

WHO. Disease outbreak news; multi-country monkeypox outbreak in non-endemic countries. World Health Organization; 2022.

23.

https:// www.who.int/emergencies/disease-outbreak-news/item/2022-DON385

24.

Velavan TP, Meyer CG (2022) Monkeypox 2022 outbreak: an update. Trop Med Int Health 27(7):604–605. https://doi.org/10.1111/tmi.13785CrossRefPubMed

25.

Actualización de recomendaciones de vacunación en el brote actual de viruela del mono. 12 de julio 2022. https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/MonkeyPox/docs/Actualizacion_Propuesta_vacunacion_Monkeypox.pdf

26.

Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y (2022) Prevention and treatment of monkeypox. Drugs 82(9):957–963. https://doi.org/10.1007/s40265-022-01742-yCrossRefPubMedPubMedCentral

27.

Siegrist EA, Sassine J, (2022) Antivirals with activity against monkeypox: a clinically oriented review [published online ahead of print, 2022 Jul 29]. Clin Infect Dis https://doi.org/10.1093/cid/ciac622

Title: Proctitis in patients with monkeypox infection: a single-center analysis of 42 consecutive cases from a multidisciplinary observational study on monkeypox proctitis
Authors: J. Guevara-Martínez
F. Prieto La-Noire
P. Arteaga-Asensio
I. Pascual-Miguelañez
R. Moraes Souza
M. Quiles
M. Montes
C. Fondevila
M. Álvarez-Gallego
Monkeypox multidisciplinary collaboration group
Publication date: 22-04-2023
Publisher: Springer International Publishing
Keywords: Sexually Transmitted Infection
Sexually Transmitted Infection
Proctitis
Sexually Transmitted Infection
Sexually Transmitted Infection
Polymerase Chain Reaction
Mpox
Mpox
Published in: Techniques in Coloproctology / Issue 12/2023
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI: https://doi.org/10.1007/s10151-023-02782-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Proctitis in patients with monkeypox infection: a single-center analysis of 42 consecutive cases from a multidisciplinary observational study on monkeypox proctitis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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