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Techniques in Coloproctology
Published in: Techniques in Coloproctology 12/2023

27-03-2023 | Rectal Cancer | Original Article

Impact of chemotherapy on surgical outcomes in ileostomy reversal: a propensity score matching study from a single centre

Authors: H.-H. Cheng, Y.-C. Shao, C.-Y. Lin, T.-W. Chiang, M.-C. Chen, T.-Y. Chiu, Y.-L. Huang, C.-C. Chen, C.-P. Chen, F.-F. Chiang

Published in: Techniques in Coloproctology | Issue 12/2023

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Abstract

Purpose

In patients with chemotherapy, there is no consensus on the timing of ileostomy closure. Ileostomy reversal could improve the quality of life and minimise the long-term adverse events of delayed closure. In this study, we evaluated the impact of chemotherapy on ileostomy closure and searched for the predictive factors for complications.

Methods

We retrospectively analysed 212 patients with rectal cancer who underwent ileostomy closure surgery during and without chemotherapy and were consecutively enrolled between 2010 and 2016. As a result of the heterogeneity of the two groups, propensity score matching (PSM) was performed with a 1:1 PSM cohort.

Results

A total of 162 patients were included in the analysis. The overall stoma closure-related complications (12.4% vs. 11.1%, p = 1.00) and major complications (2.5% vs. 6.2%, p = 0.44) were not significantly different between the two groups. Multivariate analysis demonstrated that chronic kidney disease and bevacizumab use are risk factors for major complications.

Conclusion

Patients with oral or intravenous chemotherapy can safely have ileostomy closure with an adequate time delay from chemotherapy. When patients use bevacizumab, major complications related to ileostomy closure should still be cautioned.
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Metadata
Title
Impact of chemotherapy on surgical outcomes in ileostomy reversal: a propensity score matching study from a single centre
Authors
H.-H. Cheng
Y.-C. Shao
C.-Y. Lin
T.-W. Chiang
M.-C. Chen
T.-Y. Chiu
Y.-L. Huang
C.-C. Chen
C.-P. Chen
F.-F. Chiang
Publication date
27-03-2023
Publisher
Springer International Publishing
Published in
Techniques in Coloproctology / Issue 12/2023
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-023-02790-6

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