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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2019

01-03-2019 | Review

Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma

Authors: Nico Buettner, Robert Thimme

Published in: Seminars in Immunopathology | Issue 2/2019

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Abstract

The incidence of viral hepatitis B or C (HBV/HCV) infection and hepatocellular carcinoma is higher in male compared to female populations, showing a faster disease progression and results in a worse overall survival. Indeed, women are in general better protected from viral infections and show a lower risk of death from malignant cancer in comparison to men. Females mount stronger innate and adaptive immune responses than males, and therefore, most of the autoimmune diseases occur predominantly in females. Next to occupational and/or behavioral factors, cellular and molecular differences between the two sexes contribute to this observation. In this review, we will discuss underlying mechanisms that are important for the observed sex-related differences in liver diseases. A better appreciation of these differences between the two sexes might be of value for better and gender-specific treatment options.
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Metadata
Title
Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma
Authors
Nico Buettner
Robert Thimme
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 2/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-018-0727-4

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