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Journal of Cardiovascular Translational Research

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01-03-2014

Sex Differences in Translocator Protein 18 kDa (TSPO) in the Heart: Implications for Imaging Myocardial Inflammation

Authors: DeLisa Fairweather, Michael J. Coronado, Amanda E. Garton, Jennifer L. Dziedzic, Adriana Bucek, Leslie T. Cooper Jr., Jessica E. Brandt, Fatima S. Alikhan, Haofan Wang, Christopher J. Endres, Judy Choi, Martin G. Pomper, Tomás R. Guilarte

Published in: Journal of Cardiovascular Translational Research | Issue 2/2014

Abstract

Myocarditis is more severe in men than in women and difficult to diagnose due to a lack of imaging modalities that directly detect myocardial inflammation. Translocator protein 18 kDa (TSPO) is used extensively to image brain inflammation due to its presence in CD11b⁺ brain microglia. In this study, we examined expression of TSPO and CD11b in mice with coxsackievirus B3 (CVB3) myocarditis and biopsy sections from myocarditis patients in order to determine if it could be used to image myocarditis. We found that male mice with CVB3 myocarditis upregulated more genes associated with TSPO activation than female mice. TSPO expression was increased in the heart of male mice and men with myocarditis compared with female subjects due to testosterone, where it was expressed predominantly in CD11b⁺ immune cells. We show that TSPO ligands detect myocardial inflammation using microSPECT, with increased uptake of [¹²⁵I]-IodoDPA-713 in male mice with CVB3 myocarditis compared with undiseased controls.

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Title: Sex Differences in Translocator Protein 18 kDa (TSPO) in the Heart: Implications for Imaging Myocardial Inflammation
Authors: DeLisa Fairweather
Michael J. Coronado
Amanda E. Garton
Jennifer L. Dziedzic
Adriana Bucek
Leslie T. Cooper Jr.
Jessica E. Brandt
Fatima S. Alikhan
Haofan Wang
Christopher J. Endres
Judy Choi
Martin G. Pomper
Tomás R. Guilarte
Publication date: 01-03-2014
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 2/2014
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9538-0

Keynote webinar | Spotlight on medication adherence

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Sex Differences in Translocator Protein 18 kDa (TSPO) in the Heart: Implications for Imaging Myocardial Inflammation

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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