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Journal of Cardiovascular Translational Research

Published in:

01-03-2014

The Role of Sex Differences in Autophagy in the Heart During Coxsackievirus B3-Induced Myocarditis

Authors: Andreas Koenig, Adam Sateriale, Ralph C. Budd, Sally A. Huber, Iwona A. Buskiewicz

Published in: Journal of Cardiovascular Translational Research | Issue 2/2014

Abstract

Under normal conditions, autophagy maintains cardiomyocyte health and integrity through turnover of organelles. During stress, oxygen and nutrient deprivation, or microbial infection, autophagy prolongs cardiomyocyte survival. Sex differences in induction of cell death may to some extent explain the disparity between the sexes in many human diseases. However, sex differences in gene expression, which regulate cell death and autophagy, were so far not taken in consideration to explain the sex bias of viral myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis is a sex-biased disease, with females being substantially less susceptible than males and sex hormones largely determine this bias. CVB3 was shown to induce and subvert the autophagosome for its optimal viral RNA replication. Gene expression analysis on mouse and human, healthy and CVB3-infected, cardiac samples of both sexes, suggests sex differences in autophagy-related gene expression. This review discusses the aspects of sex bias in autophagy induction in cardiomyocytes.

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Title: The Role of Sex Differences in Autophagy in the Heart During Coxsackievirus B3-Induced Myocarditis
Authors: Andreas Koenig
Adam Sateriale
Ralph C. Budd
Sally A. Huber
Iwona A. Buskiewicz
Publication date: 01-03-2014
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 2/2014
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9525-5

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The Role of Sex Differences in Autophagy in the Heart During Coxsackievirus B3-Induced Myocarditis

Abstract

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Abstract

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