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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2007

Open Access 01-12-2007 | Research article

Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study

Authors: Kim Hung Leung, Shea Ping Yip, Wa Sang Wong, Lap San Yiu, Kam Keung Chan, Wai Man Lai, Eudora YD Chow, Che Kit Lin, Wing Cheong Yam, Kin Sang Chan

Published in: BMC Infectious Diseases | Issue 1/2007

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Abstract

Background

Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphisms and TB.

Methods

A case-control study was conducted. In total, 278 pulmonary TB patients and 282 sex- and age-matched controls without TB were recruited. All subjects were ethnic Chinese. On the basis of linkage disequilibrium pattern, three genetic markers from SLC11A1 and one from the nearby IL8RB locus were selected and examined for association with TB susceptibility. These markers were genotyped using single strand conformation polymorphism analysis or fragment analysis of amplified products.

Results

Statistically significant differences in allele (P = 0.0165, OR = 1.51) and genotype (P = 0.0163, OR = 1.59) frequencies of the linked markers SLC6a/b (classically called D543N and 3'UTR) of the SLC11A1 locus were found between patients and controls. With stratification by sex, positive associations were identified in the female group for both allele (P = 0.0049, OR = 2.54) and genotype (P = 0.0075, OR = 2.74) frequencies. With stratification by age, positive associations were demonstrated in the young age group (age ≤65 years) for both allele (P = 0.0047, OR = 2.52) and genotype (P = 0.0031, OR = 2.92) frequencies. All positive findings remained significant even after correction for multiple comparisons. No significant differences were noted in either the male group or the older age group. No significant differences were found for the other markers (one SLC11A1 marker and one IL8RB marker) either.

Conclusion

This study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group.
Appendix
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Metadata
Title
Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study
Authors
Kim Hung Leung
Shea Ping Yip
Wa Sang Wong
Lap San Yiu
Kam Keung Chan
Wai Man Lai
Eudora YD Chow
Che Kit Lin
Wing Cheong Yam
Kin Sang Chan
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2007
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-7-19

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