Skip to main content
Top
Published in: Critical Care 3/2017

Open Access 01-12-2017 | Review

Seven unconfirmed ideas to improve future ICU practice

Authors: John J. Marini, Daniel De Backer, Can Ince, Mervyn Singer, Frank Van Haren, Martin Westphal, Paul Wischmeyer

Published in: Critical Care | Special Issue 3/2017

Login to get access

Abstract

With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validity of ongoing practices. These impressions are later confirmed, modified, or overturned by the results of the next trial. On the other hand, insights that stem from the intuitions of experienced clinicians, scientists and educators—while often neglected—help place current thinking into proper perspective and occasionally point the way toward formulating novel hypotheses that direct future research. Both streams of information and opinion contribute to progress. In this paper we present a wide-ranging set of unproven ‘out of the mainstream’ ideas of our FCCM faculty, each with a defensible rationale and holding clear implications for altering bedside management. Each proposition was designed deliberately to be provocative so as to raise awareness, stimulate new thinking and initiate lively dialog.
Literature
1.
go back to reference De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98–104.CrossRefPubMed De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98–104.CrossRefPubMed
2.
go back to reference De Backer D, Donadello K, Sakr Y, Ospina-Tascon GA, Salgado DR, Scolletta S, et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med. 2013;41:791–9.CrossRefPubMed De Backer D, Donadello K, Sakr Y, Ospina-Tascon GA, Salgado DR, Scolletta S, et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med. 2013;41:791–9.CrossRefPubMed
3.
go back to reference Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet. 2002;360:1395–6.CrossRefPubMed Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet. 2002;360:1395–6.CrossRefPubMed
4.
go back to reference Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, et al. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008;22:2561–8.CrossRefPubMed Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, et al. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008;22:2561–8.CrossRefPubMed
5.
go back to reference He X, Su F, Velissaris D, Salgado DR, de Souza BD, Lorent S, et al. Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock. Crit Care Med. 2012;40:2833–40.CrossRefPubMed He X, Su F, Velissaris D, Salgado DR, de Souza BD, Lorent S, et al. Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock. Crit Care Med. 2012;40:2833–40.CrossRefPubMed
6.
go back to reference Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rapidly reversed by ascorbate through an eNOS-dependent mechanism. Crit Care Med. 2008;36:2355–62.CrossRefPubMedPubMedCentral Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rapidly reversed by ascorbate through an eNOS-dependent mechanism. Crit Care Med. 2008;36:2355–62.CrossRefPubMedPubMedCentral
7.
go back to reference Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003;9:1498–505.CrossRefPubMed Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003;9:1498–505.CrossRefPubMed
8.
go back to reference Legrand M, Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C. Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Anesthesiology. 2010;112(1):119–27.CrossRefPubMed Legrand M, Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C. Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Anesthesiology. 2010;112(1):119–27.CrossRefPubMed
9.
go back to reference van Iterson M, Siegemund M, Burhop K, Ince C. Heart and gut microvascular oxygenation in pigs after resuscitation from hemorrhage by different doses of a hemoglobin based oxygen carrier. J Trauma. 2003;55:1111–24.CrossRefPubMed van Iterson M, Siegemund M, Burhop K, Ince C. Heart and gut microvascular oxygenation in pigs after resuscitation from hemorrhage by different doses of a hemoglobin based oxygen carrier. J Trauma. 2003;55:1111–24.CrossRefPubMed
10.
go back to reference Toma VA, Farcaș AD, Roman I, Sevastre B, Hathazi D, Scurtu F, et al. Comparative in vivo effects of hemoglobin-based oxygen carriers [HBOC] with varying prooxidant and physiological reactivity. PLoS One. 2016;11(4):e0153909.CrossRefPubMedPubMedCentral Toma VA, Farcaș AD, Roman I, Sevastre B, Hathazi D, Scurtu F, et al. Comparative in vivo effects of hemoglobin-based oxygen carriers [HBOC] with varying prooxidant and physiological reactivity. PLoS One. 2016;11(4):e0153909.CrossRefPubMedPubMedCentral
11.
go back to reference Ince C. The rationale for microcirculatory-guided fluid therapy. Curr Opin Crit Care. 2014;20(3):301–8.CrossRefPubMed Ince C. The rationale for microcirculatory-guided fluid therapy. Curr Opin Crit Care. 2014;20(3):301–8.CrossRefPubMed
13.
go back to reference Fu Z, Costello ML, Tsukimoto K, Prediletto R, Elliott AR, Mathieu-Costello O, West JB. High lung volume increases stress failure in pulmonary capillaries. J Appl Physiol. 1992;73:123–33.CrossRefPubMed Fu Z, Costello ML, Tsukimoto K, Prediletto R, Elliott AR, Mathieu-Costello O, West JB. High lung volume increases stress failure in pulmonary capillaries. J Appl Physiol. 1992;73:123–33.CrossRefPubMed
14.
go back to reference Broccard AF, Shapiro RS, Schmitz LL, Ravenscraft SA, Marini JJ. Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome. Crit Care Med. 1997;25(1):16–27.CrossRefPubMed Broccard AF, Shapiro RS, Schmitz LL, Ravenscraft SA, Marini JJ. Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome. Crit Care Med. 1997;25(1):16–27.CrossRefPubMed
15.
go back to reference Hotchkiss JR, Simonson DA, Marek DJ, Marini JJ, Dries DJ. Pulmonary microvascular fracture in a patient with acute respiratory distress syndrome. Crit Care Med. 2002;30(10):2368–70.CrossRefPubMed Hotchkiss JR, Simonson DA, Marek DJ, Marini JJ, Dries DJ. Pulmonary microvascular fracture in a patient with acute respiratory distress syndrome. Crit Care Med. 2002;30(10):2368–70.CrossRefPubMed
16.
go back to reference Lopez-Aguilar J, Piacentini E, Villagra A, Murias G, Pascotto S, Saenz-Valiente A, Fernandez-Segoviano P, Hotchkiss JR, Blanch L. Contributions of vascular flow and pulmonary capillary pressure to ventilator-induced lung injury. Crit Care Med. 2006;34(4):1106–12.CrossRefPubMed Lopez-Aguilar J, Piacentini E, Villagra A, Murias G, Pascotto S, Saenz-Valiente A, Fernandez-Segoviano P, Hotchkiss JR, Blanch L. Contributions of vascular flow and pulmonary capillary pressure to ventilator-induced lung injury. Crit Care Med. 2006;34(4):1106–12.CrossRefPubMed
17.
go back to reference Marini JJ, Jaber S. Dynamic predictors of VILI risk: beyond the driving pressure. Intensive Care Med. 2016;42(10):1597–600.CrossRefPubMed Marini JJ, Jaber S. Dynamic predictors of VILI risk: beyond the driving pressure. Intensive Care Med. 2016;42(10):1597–600.CrossRefPubMed
18.
go back to reference Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler Jr VG, Rivers EP, Woods CW, Kingsmore SF, 195. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013;5:195ra95. doi:10.1126/scitranslmed.3005893.CrossRefPubMedPubMedCentral Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler Jr VG, Rivers EP, Woods CW, Kingsmore SF, 195. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013;5:195ra95. doi:10.​1126/​scitranslmed.​3005893.CrossRefPubMedPubMedCentral
19.
go back to reference de Groot B, Verdoorn RC, Lameijer J, van der Velden J. High-sensitivity cardiac troponin T is an independent predictor of inhospital mortality in emergency department patients with suspected infection: a prospective observational derivation study. Emerg Med J. 2014;31(11):882–8. doi:10.1136/emermed-2013-202865.CrossRefPubMed de Groot B, Verdoorn RC, Lameijer J, van der Velden J. High-sensitivity cardiac troponin T is an independent predictor of inhospital mortality in emergency department patients with suspected infection: a prospective observational derivation study. Emerg Med J. 2014;31(11):882–8. doi:10.​1136/​emermed-2013-202865.CrossRefPubMed
20.
go back to reference Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC, GenIMS Investigators. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis [GenIMS] Study. Arch Intern Med. 2007;167(15):1655–63.CrossRefPubMedPubMedCentral Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC, GenIMS Investigators. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis [GenIMS] Study. Arch Intern Med. 2007;167(15):1655–63.CrossRefPubMedPubMedCentral
22.
go back to reference Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358(2):111–24. doi:10.1056/NEJMoa071366.CrossRefPubMed Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358(2):111–24. doi:10.​1056/​NEJMoa071366.CrossRefPubMed
23.
go back to reference Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310(16):1683–91. doi:10.1001/jama.2013.278477.CrossRefPubMed Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310(16):1683–91. doi:10.​1001/​jama.​2013.​278477.CrossRefPubMed
26.
go back to reference Mundigler G, Delle-Karth G, Koreny M, Zehetgruber M, Steindl-Munda P, Marktl W, Ferti L, Siostrzonek P. Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. Crit Care Med. 2002;30(3):536–40.CrossRefPubMed Mundigler G, Delle-Karth G, Koreny M, Zehetgruber M, Steindl-Munda P, Marktl W, Ferti L, Siostrzonek P. Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. Crit Care Med. 2002;30(3):536–40.CrossRefPubMed
30.
go back to reference Yang Y, Jiang S, Dong Y, Fan C, Zhao L, Yang X, Li J, Di S, Liang Y, Liang G, Reiter RJ, Yan Q. Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice. J Pineal Res. 2015;58:61–70.CrossRefPubMed Yang Y, Jiang S, Dong Y, Fan C, Zhao L, Yang X, Li J, Di S, Liang Y, Liang G, Reiter RJ, Yan Q. Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice. J Pineal Res. 2015;58:61–70.CrossRefPubMed
32.
go back to reference Butz DE, Cook ME, Eghbalnia HR, Assadi-Porter F, Porter WP. Changes in the natural abundance of 13CO2/12CO2 in breath due to lipopolysacchride-induced acute phase response. Rapid Commun Mass Spectrom. 2009;23(23):3729–35. doi:10.1002/rcm.4310.CrossRefPubMed Butz DE, Cook ME, Eghbalnia HR, Assadi-Porter F, Porter WP. Changes in the natural abundance of 13CO2/12CO2 in breath due to lipopolysacchride-induced acute phase response. Rapid Commun Mass Spectrom. 2009;23(23):3729–35. doi:10.​1002/​rcm.​4310.CrossRefPubMed
33.
go back to reference Butz DE, Weidmann D, Brownsword R, Cook ME, Schoeller DA, Whigham LD. Immediate biofeedback for energy balance via expired breath Δ 13CO2. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:8205–8.PubMed Butz DE, Weidmann D, Brownsword R, Cook ME, Schoeller DA, Whigham LD. Immediate biofeedback for energy balance via expired breath Δ 13CO2. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:8205–8.PubMed
Metadata
Title
Seven unconfirmed ideas to improve future ICU practice
Authors
John J. Marini
Daniel De Backer
Can Ince
Mervyn Singer
Frank Van Haren
Martin Westphal
Paul Wischmeyer
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 3/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1904-x

Other articles of this Special Issue 3/2017

Critical Care 3/2017 Go to the issue