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Langenbeck's Archives of Surgery
Published in: Langenbeck's Archives of Surgery 3/2008

01-05-2008 | Original Article

Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients

Authors: Sebastian Niedźwiecki, Tomasz Stępień, Krzysztof Kuzdak, Henryk Stępień, Roman Krupiński, Daniel Seehofer, Nada Rayes, Frank Ulrich

Published in: Langenbeck's Archives of Surgery | Issue 3/2008

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Abstract

Background and aims

There is growing evidence that cytokines and their antagonists are important in the pathogenesis of various malignancies. While there are several reports on interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and tissue expression, there is only little data available on the impact of IL-1ra serum levels. Therefore, we performed a prospective study, analyzing IL-1ra in thyroid cancer patients.

Materials and methods

We measured preoperative IL-1ra serum levels of 52 consecutive patients with thyroid cancer, 15 with benign adenoma and 27 healthy volunteers. The final histological diagnosis revealed 21 patients with papillary and 8 patients with follicular carcinoma (FTC), while 12 cases of medullary and 11 cases of anaplastic carcinoma (ATC) were observed.

Results

Compared to the control group, serum concentrations of IL-1ra were significantly higher in ATC and FTC patients. Concerning gender differences, this effect reached significance only in women with ATC and FTC. Except for the stage IV disease in ATC, there was no correlation between IL-1ra levels and International Union Against Cancer staging.

Conclusion

The findings of our study indicate that IL-1ra may play an important role in the development of ATC and FTC. Future efforts should focus on the possible application of IL-1ra as a biomarker for the above-mentioned thyroid malignancies.
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Metadata
Title
Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients
Authors
Sebastian Niedźwiecki
Tomasz Stępień
Krzysztof Kuzdak
Henryk Stępień
Roman Krupiński
Daniel Seehofer
Nada Rayes
Frank Ulrich
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 3/2008
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-007-0251-9

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