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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 1/2018

01-02-2018 | Original article

Serum adipocyte fatty acid-binding protein level is associated with arterial stiffness quantified with cardio-ankle vascular index in kidney transplant patients

Authors: Yen-Cheng Chen, Bang-Gee Hsu, Chung-Jen Lee, Ching-Chun Ho, Guan-Jin Ho, Ming-Che Lee

Published in: Clinical and Experimental Nephrology | Issue 1/2018

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Abstract

Background

Arterial stiffness is an established marker of cardiovascular risk and an independent predictor of cardiovascular disease (CVD) events and mortality in kidney transplant (KT) patients. Adipocyte fatty acid-binding protein (A-FABP), a novel adipokine, is positively associated with atherosclerosis. The present study evaluated the relationship between fasting circulating A-FABP and peripheral arterial stiffness using the cardio-ankle vascular index (CAVI) in KT patients.

Methods

Fasting blood samples were collected from 74 KT patients, and serum A-FABP levels were measured using an enzyme immunoassay. CAVI was calculated using a waveform device (CAVI-VaSera VS-1000). The cutoff values for high and low levels of arterial stiffness were defined by the CAVI values of ≥9 and <9, respectively.

Results

Thirty-four patients (45.9%) were classified into the high arterial stiffness group. Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age (p = 0.015), systolic blood pressure (p < 0.001), pulse pressure (p < 0.001), duration of kidney transplantation (p = 0.005), serum total cholesterol and triglyceride levels (p = 0.033 and 0.047, respectively), glomerular filtration rate (p = 0.019), fasting glucose levels (p = 0.012), and serum A-FABP levels (p < 0.001). Multivariate forward stepwise linear regression analysis showed that age (p = 0.004), systolic blood pressure (p = 0.001), and serum A-FABP levels (p = 0.003) were independent predictors of CAVI value in KT patients.

Conclusion

Serum fasting A-FABP level is positively associated with peripheral arterial stiffness in KT patients.
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Metadata
Title
Serum adipocyte fatty acid-binding protein level is associated with arterial stiffness quantified with cardio-ankle vascular index in kidney transplant patients
Authors
Yen-Cheng Chen
Bang-Gee Hsu
Chung-Jen Lee
Ching-Chun Ho
Guan-Jin Ho
Ming-Che Lee
Publication date
01-02-2018
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 1/2018
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-017-1438-1

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