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Diabetologia
Published in: Diabetologia 5/2008

01-05-2008 | Article

Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus

Authors: L. Uusitalo, J. Nevalainen, S. Niinistö, G. Alfthan, J. Sundvall, T. Korhonen, M. G. Kenward, H. Oja, R. Veijola, O. Simell, J. Ilonen, M. Knip, S. M. Virtanen

Published in: Diabetologia | Issue 5/2008

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Abstract

Aims/hypothesis

The aim of our study was to assess the associations of serum α- and γ-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus.

Methods

A case–control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case–control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations.

Results

Serum α- or γ-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for μmol/l increase in serum concentration of the first-year sample was 0.97 (0.92–1.03) for α-tocopherol and 1.10 (0.70–1.74) for γ-tocopherol. However, there was an interaction between high values of γ-tocopherol at the age of 1 year and the time of seroconversion (p = 0.024).

Conclusions/interpretation

It seems unlikely that high concentrations of α- or γ-tocopherol protect against advanced beta cell autoimmunity in young children.
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Metadata
Title
Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus
Authors
L. Uusitalo
J. Nevalainen
S. Niinistö
G. Alfthan
J. Sundvall
T. Korhonen
M. G. Kenward
H. Oja
R. Veijola
O. Simell
J. Ilonen
M. Knip
S. M. Virtanen
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 5/2008
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-008-0959-2

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