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European Journal of Epidemiology
Published in: European Journal of Epidemiology 6/2007

01-06-2007 | Infectious Diseases

Seroprevalence of varicella antibodies among pregnant women in Lyon-France

Authors: M. Saadatian-Elahi, Y. Mekki, C. Del Signore, B. Lina, T. Derrough, E. Caulin, J. Thierry, P. Vanhems

Published in: European Journal of Epidemiology | Issue 6/2007

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Abstract

The purpose of the study was to calculate the seroprevalence of immunity to the varicella-zoster virus (VZV) infection and to evaluate the positive predictive value (PPV) and the negative predictive value (NPV) of the self-reported history of VZV infection in pregnant women. A cross sectional study was conducted in 18 private medical analysis laboratories. Information on socio-demographic characteristics and past history of varicella or zoster were collected using a questionnaire. Blood samples were obtained to determine the serological levels of past exposure to VZV. Overall, 486 pregnant women were recruited. The seroprevalence of VZV antibodies was 98.8%. Six women were seronegative, of whom four were primiparous. The PPV was high (99.5%) while the NPV was only 10.3%. The PPV is a reliable marker of prior VZV infection. In contrast, a negative history does not predict lack of immunity and should be completed by serological analysis which might be introduced to routine antenatal blood tests.
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Metadata
Title
Seroprevalence of varicella antibodies among pregnant women in Lyon-France
Authors
M. Saadatian-Elahi
Y. Mekki
C. Del Signore
B. Lina
T. Derrough
E. Caulin
J. Thierry
P. Vanhems
Publication date
01-06-2007
Publisher
Kluwer Academic Publishers
Published in
European Journal of Epidemiology / Issue 6/2007
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-007-9136-z

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