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Archives of Virology
Published in: Archives of Virology 1/2017

01-01-2017 | Original Article

Seronegative and occult hepatitis C virus infections in patients with hematological disorders

Authors: Ghada Fahmy Helaly, Amel Gaber Elsheredy, Adel Abd El Basset Mousa, Hayat Khalifa Fadlalla Ahmed, Abd El-Gaffar Sabry Oluyemi

Published in: Archives of Virology | Issue 1/2017

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Abstract

Studies of the association between seronegative or occult (OCI) hepatitis C virus (HCV) infection, and hematological disorders have yielded controversial results. The aim of this study was to investigate seronegative and OCI HCV infections in among patients with different hematological disorders. This study included 90 anti-HCV-negative patients with either benign or malignant hematological disorders (group I), along with 20 age- and sex-matched apparently healthy subjects, who served as controls (group II). We tested for HCV RNA in sera and PBMCs by RT-nested PCR and for liver enzyme activity. Seronegativity and OCI were detected in 66.7 % and 20 % respectively, of the studied cases (group I). OCI was more evident in Hodgkin lymphoma and thalassemia. A significant increase in AST activity was observed in the seronegative and OCI groups and in ALT and AST in HCV-seronegative or OCI and negative HCV patients (p ≤ 0.05). Seronegativity and OCI are a significant clinical problem in patients with hematological disorders, warranting wider use of molecular tests combined with periodic evaluations of liver functions for diagnostic purposes.
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Metadata
Title
Seronegative and occult hepatitis C virus infections in patients with hematological disorders
Authors
Ghada Fahmy Helaly
Amel Gaber Elsheredy
Adel Abd El Basset Mousa
Hayat Khalifa Fadlalla Ahmed
Abd El-Gaffar Sabry Oluyemi
Publication date
01-01-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 1/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3049-7

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