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Open Access 01-12-2020 | Septicemia | Research Letter

RNA-expression of adrenomedullin is increased in patients with severe COVID-19

Authors: Julian Hupf, Julian Mustroph, Frank Hanses, Katja Evert, Lars S. Maier, Carsten G. Jungbauer

Published in: Critical Care | Issue 1/2020

Excerpt

Adrenomedullin (ADM) is a peptide hormone with vasodilatory effects and involved in the regulation of the endothelial barrier function. Previous research found increased ADM plasma levels in patients with sepsis and ADM levels correlated with disease severity and mortality in sepsis [1]. Although severe coronavirus disease (COVID-19) shares some clinical features of sepsis (e.g., endothelial barrier dysfunction [2]), it is not known whether pathophysiological pathways of COVID-19 resemble those of sepsis [2, 3]. To our knowledge, this is the first study to evaluate ADM in context of COVID-19 [4]. …

Geven C, Kox M, Pickkers P. Adrenomedullin and Adrenomedullin-targeted therapy as treatment strategies relevant for sepsis. Front Immunol. 2018;9:292. https://doi.org/10.3389/fimmu.2018.00292 .CrossRefPubMedPubMedCentral

Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection. Crit Care. 2020;24:307. https://doi.org/10.1186/s13054-020-03062-7 .CrossRef

Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395:1517–20. https://doi.org/10.1016/S0140-6736(20)30920-X .CrossRefPubMedPubMedCentral

Wilson DC, Schefold JC, Baldirà J, Spinetti T, Saeed K, Elke G. Adrenomedullin in COVID-19 induced endotheliitis. Crit Care. 2020;24:411. https://doi.org/10.1186/s13054-020-03151-7 .CrossRefPubMedPubMedCentral

Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of acute-illness severity in the NHS. Updated report of a working party. RCP. 2017. https://www.rcplondon.ac.uk/projects/outputs/national-early-warning-score-news-2.

Title: RNA-expression of adrenomedullin is increased in patients with severe COVID-19
Authors: Julian Hupf
Julian Mustroph
Frank Hanses
Katja Evert
Lars S. Maier
Carsten G. Jungbauer
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
COVID-19
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-03246-1

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RNA-expression of adrenomedullin is increased in patients with severe COVID-19

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At a glance: The STEP trials

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