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16-05-2022 | Septicemia | Original Article

Neonatal sepsis and Kawasaki disease

Authors: Akihito Takeuchi, Noriko Sugino, Takahiro Namba, Kei Tamai, Kazue Nakamura, Makoto Nakamura, Misao Kageyama, Takashi Yorifuji, Motoki Bonno

Published in: European Journal of Pediatrics | Issue 8/2022

Abstract

The purpose of this study is to clarify the relationship between neonatal sepsis and future development of Kawasaki disease (KD). We analyzed data from the National Hospital Organization Neonatal Intensive Care Unit (NHO-NICU) registry study in Japan. Participants in this study were children with a history of hospitalization in the NICU at the participating institutions from 2010 to 2014. A questionnaire was administered at age 3 years to obtain information about the patient’s history of KD. There were 8275 infants who were eligible for this study. At 3 years of age, parents of 2161 children responded to the follow-up survey (follow-up rate, 26.1%). Multivariate logistic regression analysis adjusted for preterm birth, sex, use of antibiotics in the NICU, parity, and maternal smoking showed that children with neonatal sepsis were more likely to have a history of KD at 3 years of age (adjusted odds ratio [aOR]: 11.67, 95% confidence interval [CI]: 2.84–47.96).

Conclusions: Among infants admitted to the NICU, neonatal sepsis might be associated with development of KD later in life. Further large studies are needed to elucidate the relationship between neonatal infections and KD development.

What is Known: • Preterm birth is known to be a risk factor for Kawasaki disease. •It is not yet known which factors related to preterm birth increase the risk of developing Kawasaki disease.
What is New: •Neonatal sepsis is associated with an increased risk of subsequent development of Kawasaki disease. •Antibiotic use in the neonatal intensive care unit may also be an independent risk factor for subsequent development of Kawasaki disease.

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Title: Neonatal sepsis and Kawasaki disease
Authors: Akihito Takeuchi
Noriko Sugino
Takahiro Namba
Kei Tamai
Kazue Nakamura
Makoto Nakamura
Misao Kageyama
Takashi Yorifuji
Motoki Bonno
Publication date: 16-05-2022
Publisher: Springer Berlin Heidelberg
Keywords: Septicemia
Septicemia
Neonatal Sepsis
Antibiotic
Premature Birth
Kawasaki Disease
Kawasaki Disease
Kawasaki Disease
Published in: European Journal of Pediatrics / Issue 8/2022
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-022-04501-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neonatal sepsis and Kawasaki disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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