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Published in: BMC Pediatrics 1/2019

Open Access 01-12-2019 | Septic Shock | Case report

Noma in a boy with septic shock: a case report

Authors: Lili Xu, Wanrui Wei, Xiaohua Ge, Sibei Wan, Jing Yu, Xiaodong Zhu

Published in: BMC Pediatrics | Issue 1/2019

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Abstract

Background

Noma is a rare disease, which is characterized by rapid progression and a high rate of mortality; however, relatively few cases of noma infection accompanied by septic shock in children have been described. Further, most health care professionals have no knowledge of this disease or of its clinical significance.

Case presentation

Herein, we present a case report of a six-year-old male patient who was diagnosed with noma infection at a Chinese pediatric medical intensive care unit (PMICU), at which time, it was discovered that he had septic shock. Following treatment by continuous renal replacement therapy (CRRT) for septic shock arising from noma, the patient was in generally good condition, and the local wound was seen to be essentially healed five weeks post-admission.

Conclusion

Noma is an opportunistic infectious disease condition. Treatment of the acute phase of noma predominantly focuses on controlling the infection and improving systemic conditions. In addition, CRRT could be considered as a treatment option for cases that present with noma accompanied by septic shock.
Literature
1.
go back to reference Ashok N, Tarakji B, Darwish S, Rodrigues JC, Altamimi MA. A review on Noma: a recent update. Glob J Health Sci. 2016;8:53–9.CrossRef Ashok N, Tarakji B, Darwish S, Rodrigues JC, Altamimi MA. A review on Noma: a recent update. Glob J Health Sci. 2016;8:53–9.CrossRef
2.
go back to reference Moran JL, Graham PL, Rockliff S, Bersten AD. Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective. Crit Care. 2010;14:R134.CrossRef Moran JL, Graham PL, Rockliff S, Bersten AD. Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective. Crit Care. 2010;14:R134.CrossRef
3.
go back to reference Srour ML, Marck K, Baratti-Mayer D. Noma: Overview of a Neglected Disease and Human Rights Violation. Am J Trop Med Hyg. 2017;96(2):268–74.CrossRef Srour ML, Marck K, Baratti-Mayer D. Noma: Overview of a Neglected Disease and Human Rights Violation. Am J Trop Med Hyg. 2017;96(2):268–74.CrossRef
4.
go back to reference Baratti-Mayer D, Gayet-Ageron A, Hugonnet S, et al. Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. Lancet Global Health. 2013;1:e87–96.CrossRef Baratti-Mayer D, Gayet-Ageron A, Hugonnet S, et al. Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. Lancet Global Health. 2013;1:e87–96.CrossRef
5.
go back to reference Farley E, Lenglet A, Ariti C, et al. Risk factors for diagnosed noma in Northwest Nigeria: a case-control study. PLoS Negl Trop Dis. 2018;12(8):e0006631.CrossRef Farley E, Lenglet A, Ariti C, et al. Risk factors for diagnosed noma in Northwest Nigeria: a case-control study. PLoS Negl Trop Dis. 2018;12(8):e0006631.CrossRef
6.
go back to reference Idigbe EO, et al. Living conditions of children at risk for noma: Nigerian experience. Oral Dis. 1999;5(2):156–62.CrossRef Idigbe EO, et al. Living conditions of children at risk for noma: Nigerian experience. Oral Dis. 1999;5(2):156–62.CrossRef
7.
go back to reference Phillips RS, Enwonwu CO, Okolo S, Hassan A. Metabolic effects of acute measles in chronically malnourished Nigerian children. J Nutr Biochem. 2004;15(5):281–8.CrossRef Phillips RS, Enwonwu CO, Okolo S, Hassan A. Metabolic effects of acute measles in chronically malnourished Nigerian children. J Nutr Biochem. 2004;15(5):281–8.CrossRef
8.
9.
go back to reference Ronco C, Tetta C, Mariano F, et al. Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis. Artif Organs. 2003;27(9):792–801.CrossRef Ronco C, Tetta C, Mariano F, et al. Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis. Artif Organs. 2003;27(9):792–801.CrossRef
10.
go back to reference Seyler L, Cotton F, Taccone FS, et al. Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care. 2011;15(3):R137.CrossRef Seyler L, Cotton F, Taccone FS, et al. Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care. 2011;15(3):R137.CrossRef
11.
go back to reference Auluck A, Pai KM. Noma: life cycle of a devastating sore - case report and literature review. J Can Dent Assoc. 2005;71(10):757.PubMed Auluck A, Pai KM. Noma: life cycle of a devastating sore - case report and literature review. J Can Dent Assoc. 2005;71(10):757.PubMed
12.
go back to reference Enwonwu CO, Falkler WA, Phillips RS. Noma (cancrum oris). Lancet. 2006;368(9530):147–56.CrossRef Enwonwu CO, Falkler WA, Phillips RS. Noma (cancrum oris). Lancet. 2006;368(9530):147–56.CrossRef
13.
go back to reference Lee YJ, Kim YJ, Won CH, et al. Nomalike necrotizing stomatitis in a child with Crohn’s disease. Pediatr Dermatol. 2017;34(5):e275–6.CrossRef Lee YJ, Kim YJ, Won CH, et al. Nomalike necrotizing stomatitis in a child with Crohn’s disease. Pediatr Dermatol. 2017;34(5):e275–6.CrossRef
Metadata
Title
Noma in a boy with septic shock: a case report
Authors
Lili Xu
Wanrui Wei
Xiaohua Ge
Sibei Wan
Jing Yu
Xiaodong Zhu
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Septic Shock
Published in
BMC Pediatrics / Issue 1/2019
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-019-1574-8

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