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01-07-2018 | Original

Sepsis-related mortality in China: a descriptive analysis

Authors: Li Weng, Xin-ying Zeng, Peng Yin, Li-jun Wang, Chun-yao Wang, Wei Jiang, Mai-geng Zhou, Bin Du, for the China Critical Care Clinical Trials Group (CCCCTG)

Published in: Intensive Care Medicine | Issue 7/2018

Abstract

Purpose

A population-level description and analysis of sepsis-related mortality in China is key to the planning and assessment of interventional strategies.

Methods

Retrospective analysis of multiple cause of death (MCOD) recorded in the population-based national mortality surveillance system (NMSS) of China. All sepsis-related deaths occurring in 605 disease surveillance points (DSPs) covering 323.8 million population across China were included in our study. Age-standardized mortality and national estimate of sepsis-related deaths were estimated using the census population in 2010 and 2015, respectively.

Results

In 2015, a total of 1,937,299 deaths occurring in any of the 605 DSPs and standardized sepsis-related mortality rate was 66.7 (95% confidence interval [CI] 66.4–67.0) deaths per 100,000 population. This produced a national estimate of 1,025,997 sepsis-related deaths. Sepsis-related mortality rates exhibited significant geographic variation. In multilevel analysis, male sex (rate ratio [RR] 1.582, 95% CI 1.570–1.595), increasing age (RR 1.914 for 5-year group, 95% CI 1.910–1.917), and presence of comorbidity (RR 2.316, 95% CI 2.298–2.335) were independently associated with increased sepsis-related mortality. Higher disposable income (RR 0.717 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.515–0.978) and mean years of education (RR 0.808 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.684–0.955) were negatively associated with sepsis-related mortality. However, population-based hospital doctors were not significantly associated with sepsis-related mortality.

Conclusions

The standardized sepsis-related mortality rate in China was high and varied according to socioeconomic indices, even though some uncertainty remained.

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Title: Sepsis-related mortality in China: a descriptive analysis
Authors: Li Weng
Xin-ying Zeng
Peng Yin
Li-jun Wang
Chun-yao Wang
Wei Jiang
Mai-geng Zhou
Bin Du
for the China Critical Care Clinical Trials Group (CCCCTG)
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 7/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5203-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sepsis-related mortality in China: a descriptive analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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