Skip to main content
Top
Published in: Supportive Care in Cancer 10/2016

Open Access 01-10-2016 | Original Article

Knowledge, attitudes, and influencing factors of cancer patients toward approving advance directives in China

Authors: Ru-jun Zheng, Yan Fu, Qiu-fen Xiang, Mei Yang, Lin Chen, Ying-kang Shi, Chun-hua Yu, Jun-ying Li

Published in: Supportive Care in Cancer | Issue 10/2016

Login to get access

Abstract

Purpose

Many cancer patients do not have advance directives (ADs), which may lead to unwanted excessive or aggressive care when patients have lost decision-making capacity. The aim of this study was to investigate knowledge and attitudes of approving ADs and explore factors associated with willing to designate ADs among cancer patients in China.

Methods

We conducted semi-structured interview method investigating 753 in-patients with cancer in two cancer centers.

Results

Of those subjects, none of the cancer patients had an AD. Only 22.4 % (118 of 526) approved ADs. Comparing with the disapproved ADs group, the approved ADs group were more likely to discuss the AD with oncologist or nurse (χ 2 = 180.4, p < 0.001) in the cancer center (χ 2 = 244.1, p < 0.001), and they chose more comfort care (χ 2 = 18.8, p < 0.001). Most of cancer patients in the two groups wanted to die at home (72.8 %, 73.7 %, respectively). The older patients (OR, 1.04, 95 % CI, 1.02–1.07, p = 0.001), female (OR, 0.55, 95 % CI, 0.35–0.88, p = 0.013), with higher education levels (OR, 3.38, 95 % CI, 1.92–5.96, p < 0.001), with religious beliefs (OR, 2.91, 95 % CI, 1.71–4.94, p < 0.001), and with higher scores of ECOG (OR, 1.46, 95 % CI, 1.17–1.82, p = 0.001) were associated with desiring for ADs.

Conclusions

Our findings indicate that there was a dearth of knowledge and different attitudes toward approving ADs among cancer patients, and some factors of demographic and clinical characteristics influenced their willing to designate ADs. This research highlights the importance of propagandizing the ADs to the public, especially to the patients, and further discussing with them when the time is ripe.
Literature
1.
go back to reference Dzeng E, Colaianni A, Roland M, et al. (2015) Influence of institutional culture and policies on do-not-resuscitate decision making at the end of life. JAMA Intern Med 175:812–819CrossRefPubMed Dzeng E, Colaianni A, Roland M, et al. (2015) Influence of institutional culture and policies on do-not-resuscitate decision making at the end of life. JAMA Intern Med 175:812–819CrossRefPubMed
3.
go back to reference Burkle CM, Mueller PS, Swetz KM, et al. (2012) Physician perspectives and compliance with patient advance directives: the role external factors play on physician decision making. BMC Med Ethics 13:31CrossRefPubMedPubMedCentral Burkle CM, Mueller PS, Swetz KM, et al. (2012) Physician perspectives and compliance with patient advance directives: the role external factors play on physician decision making. BMC Med Ethics 13:31CrossRefPubMedPubMedCentral
4.
go back to reference Pennec S, Monnier A, Pontone S, et al. (2012) End-of-life medical decisions in France: a death certificate follow-up survey 5 years after the 2005 act of parliament on patients’ rights and end of life. BMC Palliat Care 11:25CrossRefPubMedPubMedCentral Pennec S, Monnier A, Pontone S, et al. (2012) End-of-life medical decisions in France: a death certificate follow-up survey 5 years after the 2005 act of parliament on patients’ rights and end of life. BMC Palliat Care 11:25CrossRefPubMedPubMedCentral
5.
go back to reference Teno JM, Gruneir A, Schwartz Z, et al. (2007) Association between advance directives and quality of end-of-life care: a national study. J Am Geriatr Soc 55:189–194CrossRefPubMed Teno JM, Gruneir A, Schwartz Z, et al. (2007) Association between advance directives and quality of end-of-life care: a national study. J Am Geriatr Soc 55:189–194CrossRefPubMed
6.
go back to reference Wiesing U, Jox RJ, Hessler HJ, et al. (2010) A new law on advance directives in Germany. J Med Ethics 36:779–783CrossRefPubMed Wiesing U, Jox RJ, Hessler HJ, et al. (2010) A new law on advance directives in Germany. J Med Ethics 36:779–783CrossRefPubMed
8.
go back to reference Gristina GR, Martin E, Ranieri VM (2012) Regulation of advance directives in Italy: a bad law in the making. Intensive Care Med 38:1897–1900CrossRefPubMed Gristina GR, Martin E, Ranieri VM (2012) Regulation of advance directives in Italy: a bad law in the making. Intensive Care Med 38:1897–1900CrossRefPubMed
9.
go back to reference Cui J, Zhou LJ, Zhao JJ (2008) Origination and status of living wills. Chinese Journal of Nursing 43(9):860–861 Cui J, Zhou LJ, Zhao JJ (2008) Origination and status of living wills. Chinese Journal of Nursing 43(9):860–861
10.
go back to reference Gu X, Chen M, Liu M, et al (2016) End-of-life decision-making of terminally ill cancer patients in a tertiary cancer center in Shanghai, China. Support Care Cancer 24(5):2209–2215CrossRefPubMed Gu X, Chen M, Liu M, et al (2016) End-of-life decision-making of terminally ill cancer patients in a tertiary cancer center in Shanghai, China. Support Care Cancer 24(5):2209–2215CrossRefPubMed
11.
go back to reference Dow LA, Matsuyama RK, Ramakrishnan Vet al (2010) Paradoxes in advance care planning: the complex relationship of oncology patients, their physicians, and advance medical directives. J Clin Oncol 28:299–304 Dow LA, Matsuyama RK, Ramakrishnan Vet al (2010) Paradoxes in advance care planning: the complex relationship of oncology patients, their physicians, and advance medical directives. J Clin Oncol 28:299–304
12.
go back to reference Fukui S, Fujita J, Tsujimura M, et al. (2011) Predictors of home death of home palliative cancer care patients: a cross-sectional nationwide survey. Int J Nurs Stud 48:1393–1400CrossRefPubMed Fukui S, Fujita J, Tsujimura M, et al. (2011) Predictors of home death of home palliative cancer care patients: a cross-sectional nationwide survey. Int J Nurs Stud 48:1393–1400CrossRefPubMed
13.
go back to reference Fukui S, Fukui N, Kawagoe H (2004) Predictors of place of death for Japanese patients with advanced-stage malignant disease in home care settings: a nationwide survey. Cancer 101:421–429CrossRefPubMed Fukui S, Fukui N, Kawagoe H (2004) Predictors of place of death for Japanese patients with advanced-stage malignant disease in home care settings: a nationwide survey. Cancer 101:421–429CrossRefPubMed
14.
go back to reference Mosher CE, Adams RN, Helft PR, et al (2016) Family caregiving challenges in advanced colorectal cancer: patient and caregiver perspectives. Support Care Cancer 24(5):2017–2024CrossRefPubMed Mosher CE, Adams RN, Helft PR, et al (2016) Family caregiving challenges in advanced colorectal cancer: patient and caregiver perspectives. Support Care Cancer 24(5):2017–2024CrossRefPubMed
15.
go back to reference Nicholas LH, Langa KM, Iwashyna TJ, et al. (2011) Regional variation in the association between advance directives and end-of-life Medicare expenditures. JAMA 306:1447–1453CrossRefPubMedPubMedCentral Nicholas LH, Langa KM, Iwashyna TJ, et al. (2011) Regional variation in the association between advance directives and end-of-life Medicare expenditures. JAMA 306:1447–1453CrossRefPubMedPubMedCentral
16.
go back to reference Molloy DW, Guyatt GH, Russo R, et al. (2000) Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA 283:1437–1444CrossRefPubMed Molloy DW, Guyatt GH, Russo R, et al. (2000) Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA 283:1437–1444CrossRefPubMed
17.
go back to reference Weeks WB, Kofoed LL, Wallace AE, et al. (1994) Advance directives and the cost of terminal hospitalization. Arch Intern Med 154:2077–2083CrossRefPubMed Weeks WB, Kofoed LL, Wallace AE, et al. (1994) Advance directives and the cost of terminal hospitalization. Arch Intern Med 154:2077–2083CrossRefPubMed
18.
go back to reference Degenholtz HB, Rhee Y, Arnold RM (2004) Brief communication: the relationship between having a living will and dying in place. Ann Intern Med 141:113–117CrossRefPubMed Degenholtz HB, Rhee Y, Arnold RM (2004) Brief communication: the relationship between having a living will and dying in place. Ann Intern Med 141:113–117CrossRefPubMed
19.
go back to reference Chambers CV, Diamond JJ, Perkel RL, et al. (1994) Relationship of advance directives to hospital charges in a Medicare population. Arch Intern Med 154:541–547CrossRefPubMed Chambers CV, Diamond JJ, Perkel RL, et al. (1994) Relationship of advance directives to hospital charges in a Medicare population. Arch Intern Med 154:541–547CrossRefPubMed
20.
go back to reference Asai A, Miura Y, Tanabe N, et al. (1998) Advance directives and other medical decisions concerning the end of life in cancer patients in Japan. Eur J Cancer 34:1582–1586CrossRefPubMed Asai A, Miura Y, Tanabe N, et al. (1998) Advance directives and other medical decisions concerning the end of life in cancer patients in Japan. Eur J Cancer 34:1582–1586CrossRefPubMed
21.
go back to reference Tan TS, Jatoi A (2008) An update on advance directives in the medical record: findings from 1186 consecutive patients with unresectable exocrine pancreas cancer. J Gastrointest Cancer 39:100–103CrossRefPubMed Tan TS, Jatoi A (2008) An update on advance directives in the medical record: findings from 1186 consecutive patients with unresectable exocrine pancreas cancer. J Gastrointest Cancer 39:100–103CrossRefPubMed
22.
go back to reference Hopp FP (2000) Preferences for surrogate decision makers, informal communication, and advance directives among community-dwelling elders: results from a national study. Gerontologist 40:449–457CrossRefPubMed Hopp FP (2000) Preferences for surrogate decision makers, informal communication, and advance directives among community-dwelling elders: results from a national study. Gerontologist 40:449–457CrossRefPubMed
23.
go back to reference Song J, Ratner ER, Wall MM, et al. (2010) Effect of an end-of-life planning intervention on the completion of advance directives in homeless persons: a randomized trial. Ann Intern Med 153:76–84CrossRefPubMed Song J, Ratner ER, Wall MM, et al. (2010) Effect of an end-of-life planning intervention on the completion of advance directives in homeless persons: a randomized trial. Ann Intern Med 153:76–84CrossRefPubMed
24.
go back to reference Singer PA, Thiel EC, Naylor CD, et al. (1995) Life-sustaining treatment preferences of hemodialysis patients: implications for advance directives. J Am Soc Nephrol 6:1410–1417PubMed Singer PA, Thiel EC, Naylor CD, et al. (1995) Life-sustaining treatment preferences of hemodialysis patients: implications for advance directives. J Am Soc Nephrol 6:1410–1417PubMed
25.
go back to reference Trarieux-Signol S, Moreau S, Gourin MP, et al. (2014) Factors associated with the designation of a health care proxy and writing advance directives for patients suffering from haematological malignancies. BMC Palliat Care 13:57CrossRefPubMedPubMedCentral Trarieux-Signol S, Moreau S, Gourin MP, et al. (2014) Factors associated with the designation of a health care proxy and writing advance directives for patients suffering from haematological malignancies. BMC Palliat Care 13:57CrossRefPubMedPubMedCentral
26.
go back to reference Ewer MS, Taubert JK (1995) Advance directives in the intensive care unit of a tertiary cancer center. Cancer 76:1268–1274CrossRefPubMed Ewer MS, Taubert JK (1995) Advance directives in the intensive care unit of a tertiary cancer center. Cancer 76:1268–1274CrossRefPubMed
27.
go back to reference Periyakoil VS, Neri E, Fong A, et al. (2014) Do unto others: doctors’ personal end-of-life resuscitation preferences and their attitudes toward advance directives. PLoS One 9:e98246CrossRefPubMedPubMedCentral Periyakoil VS, Neri E, Fong A, et al. (2014) Do unto others: doctors’ personal end-of-life resuscitation preferences and their attitudes toward advance directives. PLoS One 9:e98246CrossRefPubMedPubMedCentral
28.
go back to reference Holley JL, Stackiewicz L, Dacko C, et al. (1997) Factors influencing dialysis patients’ completion of advance directives. Am J Kidney Dis 30:356–360CrossRefPubMed Holley JL, Stackiewicz L, Dacko C, et al. (1997) Factors influencing dialysis patients’ completion of advance directives. Am J Kidney Dis 30:356–360CrossRefPubMed
29.
go back to reference Blackmer J, Ross L (2002) Awareness and use of advance directives in the spinal cord injured population. Spinal Cord 40:581–594CrossRefPubMed Blackmer J, Ross L (2002) Awareness and use of advance directives in the spinal cord injured population. Spinal Cord 40:581–594CrossRefPubMed
30.
go back to reference Mahaney-Price AF, Hilgeman MM, Davis LL, et al. (2014) Living will status and desire for living will help among rural Alabama veterans. Res Nurs Health 37:379–390CrossRefPubMed Mahaney-Price AF, Hilgeman MM, Davis LL, et al. (2014) Living will status and desire for living will help among rural Alabama veterans. Res Nurs Health 37:379–390CrossRefPubMed
32.
go back to reference Li YM (2014) “Advance directives” and death with dignity. Philosophical Trends 4:79–84 Li YM (2014) “Advance directives” and death with dignity. Philosophical Trends 4:79–84
33.
go back to reference Freer JP, Eubanks M, Parker B et al (2006) Advance directives: ambulatory patients’ knowledge and perspectives. Am J Med 119:1088.e9–13 Freer JP, Eubanks M, Parker B et al (2006) Advance directives: ambulatory patients’ knowledge and perspectives. Am J Med 119:1088.e9–13
34.
go back to reference Go RS, Hammes BA, Lee JA, et al. (2007) Advance directives among health care professionals at a community-based cancer center. Mayo Clin Proc 82:1487–1490CrossRefPubMed Go RS, Hammes BA, Lee JA, et al. (2007) Advance directives among health care professionals at a community-based cancer center. Mayo Clin Proc 82:1487–1490CrossRefPubMed
35.
go back to reference Reilly BM, Magnussen CR, Ross J, et al. (1994) Can we talk? Inpatient discussions about advance directives in a community hospital. Attending physicians’ attitudes, their inpatients’ wishes, and reported experience. Arch Intern Med 154:2299–2308CrossRefPubMed Reilly BM, Magnussen CR, Ross J, et al. (1994) Can we talk? Inpatient discussions about advance directives in a community hospital. Attending physicians’ attitudes, their inpatients’ wishes, and reported experience. Arch Intern Med 154:2299–2308CrossRefPubMed
36.
go back to reference Zhou K, Zhang X, Ding Y, et al. (2015) Inequality trends of health workforce in different stages of medical system reform (1985-2011) in China. Hum Resour Health 13:94CrossRefPubMedPubMedCentral Zhou K, Zhang X, Ding Y, et al. (2015) Inequality trends of health workforce in different stages of medical system reform (1985-2011) in China. Hum Resour Health 13:94CrossRefPubMedPubMedCentral
37.
go back to reference Sun Z, Wang S, Barnes SR (2016) Understanding congestion in China’s medical market: an incentive structure perspective. Health Policy Plan 31:390–403CrossRefPubMed Sun Z, Wang S, Barnes SR (2016) Understanding congestion in China’s medical market: an incentive structure perspective. Health Policy Plan 31:390–403CrossRefPubMed
38.
go back to reference Evans N, Bausewein C, Menaca A, et al. (2012) A critical review of advance directives in Germany: attitudes, use and healthcare professionals’ compliance. Patient Educ Couns 87:277–288CrossRefPubMed Evans N, Bausewein C, Menaca A, et al. (2012) A critical review of advance directives in Germany: attitudes, use and healthcare professionals’ compliance. Patient Educ Couns 87:277–288CrossRefPubMed
39.
go back to reference Emanuel LL, Barry MJ, Stoeckle JD, et al. (1991) Advance directives for medical care–a case for greater use. N Engl J Med 324:889–895CrossRefPubMed Emanuel LL, Barry MJ, Stoeckle JD, et al. (1991) Advance directives for medical care–a case for greater use. N Engl J Med 324:889–895CrossRefPubMed
40.
go back to reference Camhi SL, Mercado AF, Morrison RS, et al. (2009) Deciding in the dark: advance directives and continuation of treatment in chronic critical illness. Crit Care Med 37:919–925CrossRefPubMedPubMedCentral Camhi SL, Mercado AF, Morrison RS, et al. (2009) Deciding in the dark: advance directives and continuation of treatment in chronic critical illness. Crit Care Med 37:919–925CrossRefPubMedPubMedCentral
43.
go back to reference Goff SL, Eneanya ND, Feinberg R, et al. (2015) Advance care planning: a qualitative study of dialysis patients and families. Clin J Am Soc Nephrol 10:390–400CrossRefPubMedPubMedCentral Goff SL, Eneanya ND, Feinberg R, et al. (2015) Advance care planning: a qualitative study of dialysis patients and families. Clin J Am Soc Nephrol 10:390–400CrossRefPubMedPubMedCentral
44.
go back to reference Chawla N, Arora NK (2013) Why do some patients prefer to leave decisions up to the doctor: lack of self-efficacy or a matter of trust. J Cancer Surviv 7:592–601CrossRefPubMed Chawla N, Arora NK (2013) Why do some patients prefer to leave decisions up to the doctor: lack of self-efficacy or a matter of trust. J Cancer Surviv 7:592–601CrossRefPubMed
45.
go back to reference Lee YY, Lin JL (2011) How much does trust really matter? A study of the longitudinal effects of trust and decision-making preferences on diabetic patient outcomes. Patient Educ Couns 85:406–412CrossRefPubMed Lee YY, Lin JL (2011) How much does trust really matter? A study of the longitudinal effects of trust and decision-making preferences on diabetic patient outcomes. Patient Educ Couns 85:406–412CrossRefPubMed
46.
go back to reference Sanders J (2015) Finding the right words at the right time–high-value advance care planning. N Engl J Med 372:598–599CrossRefPubMed Sanders J (2015) Finding the right words at the right time–high-value advance care planning. N Engl J Med 372:598–599CrossRefPubMed
47.
go back to reference Levinson W, Kao A, Kuby A, et al. (2005) Not all patients want to participate in decision making. A national study of public preferences. J Gen Intern Med 20:531–535PubMed Levinson W, Kao A, Kuby A, et al. (2005) Not all patients want to participate in decision making. A national study of public preferences. J Gen Intern Med 20:531–535PubMed
49.
go back to reference Zhang J, Yang D, Deng Y, et al. (2015) The willingness and actual situation of Chinese cancer patients and their family members participating in medical decision-making. Psychooncology 24:1663–1669CrossRefPubMed Zhang J, Yang D, Deng Y, et al. (2015) The willingness and actual situation of Chinese cancer patients and their family members participating in medical decision-making. Psychooncology 24:1663–1669CrossRefPubMed
50.
go back to reference Oulton J, Rhodes SM, Howe C, et al. (2015) Advance directives for older adults in the emergency department: a systematic review. J Palliat Med 18:500–505CrossRefPubMed Oulton J, Rhodes SM, Howe C, et al. (2015) Advance directives for older adults in the emergency department: a systematic review. J Palliat Med 18:500–505CrossRefPubMed
51.
go back to reference Smith AK, McCarthy EP, Paulk E, et al. (2008) Racial and ethnic differences in advance care planning among patients with cancer: impact of terminal illness acknowledgment, religiousness, and treatment preferences. J Clin Oncol 26:4131–4137CrossRefPubMedPubMedCentral Smith AK, McCarthy EP, Paulk E, et al. (2008) Racial and ethnic differences in advance care planning among patients with cancer: impact of terminal illness acknowledgment, religiousness, and treatment preferences. J Clin Oncol 26:4131–4137CrossRefPubMedPubMedCentral
53.
go back to reference Martin DK, Thiel EC, Singer PA (1999) A new model of advance care planning: observations from people with HIV. Arch Intern Med 159:86–92CrossRefPubMed Martin DK, Thiel EC, Singer PA (1999) A new model of advance care planning: observations from people with HIV. Arch Intern Med 159:86–92CrossRefPubMed
Metadata
Title
Knowledge, attitudes, and influencing factors of cancer patients toward approving advance directives in China
Authors
Ru-jun Zheng
Yan Fu
Qiu-fen Xiang
Mei Yang
Lin Chen
Ying-kang Shi
Chun-hua Yu
Jun-ying Li
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 10/2016
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3223-1

Other articles of this Issue 10/2016

Supportive Care in Cancer 10/2016 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine