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Virchows Archiv

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01-10-2021 | Seminoma | Letter to the Editor

Morphological and molecular heterogeneity in testicular germ cell tumors: implications for dedicated investigations

Authors: João Lobo, Carmen Jerónimo, Rui Henrique

Published in: Virchows Archiv | Issue 4/2021

Excerpt

Dear Editor, …

Lobo J, Costa AL, Vilela-Salgueiro B, Rodrigues A, Guimaraes R, Cantante M, Lopes P, Antunes L, Jeronimo C, Henrique R (2018) Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists. Hum Pathol 82:113–124. https://doi.org/10.1016/j.humpath.2018.07.016CrossRefPubMed

Miyai K, Yonekura Y, Ito K, Matsukuma S, Tsuda H (2021) Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors. Virchows Arch. https://doi.org/10.1007/s00428-021-03168-5CrossRefPubMed

Lobo J, Gillis AJM, Jeronimo C, Henrique R, Looijenga LHJ (2019) Human germ cell tumors are developmental cancers: impact of epigenetics on pathobiology and clinic. Int J Mol Sci 20. https://doi.org/10.3390/ijms20020258

Lobo J, Constancio V, Leite-Silva P, Guimaraes R, Cantante M, Braga I, Mauricio J, Looijenga LHJ, Henrique R, Jeronimo C (2021) Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient tissue samples Clin. Epigenetics 13:70. https://doi.org/10.1186/s13148-021-01048-yCrossRef

Costa AL, Moreira-Barbosa C, Lobo J, Vilela-Salgueiro B, Cantante M, Guimaraes R, Lopes P, Braga I, Oliveira J, Antunes L, Henrique R, Jeronimo C (2018) DNA methylation profiling as a tool for testicular germ cell tumors subtyping. Epigenomics 10:1511–1523. https://doi.org/10.2217/epi-2018-0034CrossRefPubMed

Title: Morphological and molecular heterogeneity in testicular germ cell tumors: implications for dedicated investigations
Authors: João Lobo
Carmen Jerónimo
Rui Henrique
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keywords: Seminoma
Nonseminoma
Seminoma
Nonseminoma
Epigenetics
Published in: Virchows Archiv / Issue 4/2021
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-021-03194-3

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Morphological and molecular heterogeneity in testicular germ cell tumors: implications for dedicated investigations

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