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Endocrine
Published in: Endocrine 2/2014

01-06-2014 | Research Letter

Selective blockade of estrogen receptor beta improves wound healing in diabetes

Authors: Vivekananda Gupta Sunkari, Ileana R. Botusan, Octavian Savu, Jacob Grünler, Xiaowei Zheng, Jan-Åke Gustafsson, Kerstin Brismar, Sergiu-Bogdan Catrina

Published in: Endocrine | Issue 2/2014

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Excerpt

Diabetic ulcer is a major complication of diabetes with a high burden on society resources. Despite concerted efforts in improving diabetes care, delayed wound healing in diabetes remains a common, dreaded complication [1]. The pathogenic mechanisms behind impaired wound healing in diabetes are poorly understood, and therefore, no specific targeted therapy is available. …
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G.S. Ashcroft, J. Dodsworth, E. van Boxtel, R.W. Tarnuzzer, M.A. Horan, G.S. Schultz, M.W. Ferguson, Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat. Med. 3(11), 1209–1215 (1997)PubMedCrossRef
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G.S. Ashcroft, T. Greenwell-Wild, M.A. Horan, S.M. Wahl, M.W. Ferguson, Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am. J. Pathol. 155(4), 1137–1146 (1999)PubMedCentralPubMedCrossRef
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F. Al-Mulla, S.J. Leibovich, I.M. Francis, M.S. Bitar, Impaired TGF-beta signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes. Mol. BioSyst. 7(11), 3006–3020 (2011)PubMedCrossRef
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L. Campbell, E. Emmerson, F. Davies, S.C. Gilliver, A. Krust, P. Chambon, G.S. Ashcroft, M.J. Hardman, Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J. Exp. Med. 207(9), 1825–1833 (2010)PubMedCentralPubMedCrossRef
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I.R. Botusan, V.G. Sunkari, O. Savu, A.I. Catrina, J. Grunler, S. Lindberg, T. Pereira, S. Yla-Herttuala, L. Poellinger, K. Brismar, S.B. Catrina, Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc. Natl. Acad. Sci. USA 105(49), 19426–19431 (2008)PubMedCentralPubMedCrossRef
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J.F. Arnal, C. Fontaine, A. Billon-Gales, J. Favre, H. Laurell, F. Lenfant, P. Gourdy, Estrogen receptors and endothelium. Arterioscler. Thromb. Vasc. Biol. 30(8), 1506–1512 (2010)PubMedCrossRef
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A. Giddabasappa, J.R. Eswaraka, C.M. Barrett, M.N. Bauler, Z. Wu, M. Yepuru, D.D. Miller, J.T. Dalton, Beta-LGND2, an ERbeta selective agonist, inhibits pathologic retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 53(8), 5066–5075 (2012)PubMedCrossRef
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P. Mak, I. Leav, B. Pursell, D. Bae, X. Yang, C.A. Taglienti, L.M. Gouvin, V.M. Sharma, A.M. Mercurio, ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 17(4), 319–332 (2010)PubMedCentralPubMedCrossRef
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Y. Han, X. Li, S. Zhou, G. Meng, Y. Xiao, W. Zhang, Z. Wang, L. Xie, Z. Liu, H. Lu, Y. Ji, 17ss-Estradiol antagonizes the down-regulation of ERalpha/NOS-3 signaling in vascular endothelial dysfunction of female diabetic rats. PLoS ONE 7(11), e50402 (2012)PubMedCentralPubMedCrossRef
Metadata
Title
Selective blockade of estrogen receptor beta improves wound healing in diabetes
Authors
Vivekananda Gupta Sunkari
Ileana R. Botusan
Octavian Savu
Jacob Grünler
Xiaowei Zheng
Jan-Åke Gustafsson
Kerstin Brismar
Sergiu-Bogdan Catrina
Publication date
01-06-2014
Publisher
Springer US
Published in
Endocrine / Issue 2/2014
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-013-0144-3

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