Skip to main content
Top
Published in: BMC Pulmonary Medicine 1/2016

Open Access 01-12-2016 | Research article

Sedation during bronchoscopy: data from a nationwide sedation and monitoring survey

Authors: Thomas Gaisl, Daniel J. Bratton, Ludwig T. Heuss, Malcolm Kohler, Christian Schlatzer, Marco P. Zalunardo, Martin Frey, Daniel Franzen

Published in: BMC Pulmonary Medicine | Issue 1/2016

Login to get access

Abstract

Background

There is limited knowledge on practice patterns in procedural sedation and analgesia (PSA), the use of propofol, and monitoring during flexible bronchoscopy (FB). The purpose of this study was to assess the current practice patterns of FBs and to focus on the use of propofol, the education of the proceduralist, and the involvement of anaesthesiologists during FB.

Methods

An anonymous questionnaire was sent to 299 pulmonologists. Only respondents who were active physicians in adult respiratory medicine performing FB were subsequently analysed.

Results

The response rate was 78 % and 27,149 FB in the previous 12 months were analysed. The overall sedation-related morbidity rate was 0.02 % and mortality was 7/100’000 FB. Sedation was used in 95 % of bronchoscopies. The main drugs used for PSA were propofol (77 %) and midazolam (46 %). In 84 % of PSAs propofol was used without the attendance of an anaesthesiologist. The use of propofol was associated with high volume bronchoscopists (p < 0.010) and career-young pulmonologists (p < 0.001). While monitoring vital parameters has become standard practice, pulmonologists reported a very low rate of systematic basic education and training in the field of PSA (50 %).

Conclusions

In Switzerland, PSA during FB is mostly performed with propofol without the attendance of an anaesthesiologist and the use of this drug is expected to increase in the future. While monitoring standards are very high there is need for policies to improve education, systematic training, and support for pulmonologists for PSA during FB.
Literature
1.
go back to reference Panchabhai TS, Mehta AC. Historical perspectives of bronchoscopy. Connecting the dots. Ann Am Thorac Soc. 2015;12(5):631–41.CrossRefPubMed Panchabhai TS, Mehta AC. Historical perspectives of bronchoscopy. Connecting the dots. Ann Am Thorac Soc. 2015;12(5):631–41.CrossRefPubMed
2.
go back to reference Ni YL, Lo YL, Lin TY, Fang YF, Kuo HP. Conscious sedation reduces patient discomfort and improves satisfaction in flexible bronchoscopy. Chang Gung Med J. 2010;33(4):443–52.PubMed Ni YL, Lo YL, Lin TY, Fang YF, Kuo HP. Conscious sedation reduces patient discomfort and improves satisfaction in flexible bronchoscopy. Chang Gung Med J. 2010;33(4):443–52.PubMed
3.
go back to reference Putinati S, Ballerin L, Corbetta L, Trevisani L, Potena A. Patient satisfaction with conscious sedation for bronchoscopy. Chest. 1999;115(5):1437–40.CrossRefPubMed Putinati S, Ballerin L, Corbetta L, Trevisani L, Potena A. Patient satisfaction with conscious sedation for bronchoscopy. Chest. 1999;115(5):1437–40.CrossRefPubMed
4.
go back to reference Silvestri GA, Vincent BD, Wahidi MM, Robinette E, Hansbrough JR, Downie GH. A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy. Chest. 2009;135(1):41–7.CrossRefPubMed Silvestri GA, Vincent BD, Wahidi MM, Robinette E, Hansbrough JR, Downie GH. A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy. Chest. 2009;135(1):41–7.CrossRefPubMed
5.
go back to reference Smyth CM, Stead RJ. Survey of flexible fibreoptic bronchoscopy in the United Kingdom. Eur Respir J. 2002;19(3):458–63.CrossRefPubMed Smyth CM, Stead RJ. Survey of flexible fibreoptic bronchoscopy in the United Kingdom. Eur Respir J. 2002;19(3):458–63.CrossRefPubMed
6.
go back to reference Dang D, Robinson PC, Winnicki S, Jersmann HP. The safety of flexible fibre-optic bronchoscopy and proceduralist-administered sedation: a tertiary referral centre experience. Intern Med J. 2012;42(3):300–5.CrossRefPubMed Dang D, Robinson PC, Winnicki S, Jersmann HP. The safety of flexible fibre-optic bronchoscopy and proceduralist-administered sedation: a tertiary referral centre experience. Intern Med J. 2012;42(3):300–5.CrossRefPubMed
7.
go back to reference Du Rand IA, Blaikley J, Booton R, Chaudhuri N, Gupta V, Khalid S, et al. British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax. 2013;68 Suppl 1:i1–i44.CrossRefPubMed Du Rand IA, Blaikley J, Booton R, Chaudhuri N, Gupta V, Khalid S, et al. British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax. 2013;68 Suppl 1:i1–i44.CrossRefPubMed
8.
go back to reference Wahidi MM, Jain P, Jantz M, Lee P, Mackensen GB, Barbour SY, et al. American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. Chest. 2011;140(5):1342–50.CrossRefPubMed Wahidi MM, Jain P, Jantz M, Lee P, Mackensen GB, Barbour SY, et al. American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. Chest. 2011;140(5):1342–50.CrossRefPubMed
9.
go back to reference Wood-Baker R, Burdon J, McGregor A, Robinson P, Seal P, Thoracic Society of A, et al. Fibre-optic bronchoscopy in adults: a position paper of The Thoracic Society of Australia and New Zealand. Intern Med J. 2001;31(8):479–87.CrossRefPubMed Wood-Baker R, Burdon J, McGregor A, Robinson P, Seal P, Thoracic Society of A, et al. Fibre-optic bronchoscopy in adults: a position paper of The Thoracic Society of Australia and New Zealand. Intern Med J. 2001;31(8):479–87.CrossRefPubMed
10.
go back to reference Jose RJ, Shaefi S, Navani N. Anesthesia for bronchoscopy. Curr Opin Anaesthesiol. 2014;27(4):453–7.CrossRefPubMed Jose RJ, Shaefi S, Navani N. Anesthesia for bronchoscopy. Curr Opin Anaesthesiol. 2014;27(4):453–7.CrossRefPubMed
11.
go back to reference Grendelmeier P, Kurer G, Pflimlin E, Tamm M, Stolz D. Feasibility and safety of propofol sedation in flexible bronchoscopy. Swiss Med Wkly. 2011;141:w13248.PubMed Grendelmeier P, Kurer G, Pflimlin E, Tamm M, Stolz D. Feasibility and safety of propofol sedation in flexible bronchoscopy. Swiss Med Wkly. 2011;141:w13248.PubMed
12.
go back to reference Hassan C, Rex DK, Cooper GS, Benamouzig R. Endoscopist-directed propofol administration versus anesthesiologist assistance for colorectal cancer screening: a cost-effectiveness analysis. Endoscopy. 2012;44(5):456–64.CrossRefPubMed Hassan C, Rex DK, Cooper GS, Benamouzig R. Endoscopist-directed propofol administration versus anesthesiologist assistance for colorectal cancer screening: a cost-effectiveness analysis. Endoscopy. 2012;44(5):456–64.CrossRefPubMed
13.
go back to reference Pickles J, Jeffrey M, Datta A, Jeffrey AA. Is preparation for bronchoscopy optimal? Eur Respir J. 2003;22(2):203–6.CrossRefPubMed Pickles J, Jeffrey M, Datta A, Jeffrey AA. Is preparation for bronchoscopy optimal? Eur Respir J. 2003;22(2):203–6.CrossRefPubMed
14.
go back to reference Webb ST, Hunter DN. Is sedation by non-anaesthetists really safe? Br J Anaesth. 2013;111(2):136–8.CrossRefPubMed Webb ST, Hunter DN. Is sedation by non-anaesthetists really safe? Br J Anaesth. 2013;111(2):136–8.CrossRefPubMed
15.
go back to reference Kulling D, Rothenbuhler R, Inauen W. Safety of nonanesthetist sedation with propofol for outpatient colonoscopy and esophagogastroduodenoscopy. Endoscopy. 2003;35(8):679–82.CrossRefPubMed Kulling D, Rothenbuhler R, Inauen W. Safety of nonanesthetist sedation with propofol for outpatient colonoscopy and esophagogastroduodenoscopy. Endoscopy. 2003;35(8):679–82.CrossRefPubMed
16.
go back to reference Froehlich F, Gonvers JJ, Fried M. Conscious sedation, clinically relevant complications and monitoring of endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 1994;26(2):231–4.CrossRefPubMed Froehlich F, Gonvers JJ, Fried M. Conscious sedation, clinically relevant complications and monitoring of endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 1994;26(2):231–4.CrossRefPubMed
17.
go back to reference Heuss LT, Froehlich F, Beglinger C. Changing patterns of sedation and monitoring practice during endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 2005;37(2):161–6.CrossRefPubMed Heuss LT, Froehlich F, Beglinger C. Changing patterns of sedation and monitoring practice during endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 2005;37(2):161–6.CrossRefPubMed
18.
go back to reference Gupta AA, Sehgal IS, Dhooria S, Singh N, Aggarwal AN, Gupta D, et al. Indications for performing flexible bronchoscopy: Trends over 34 years at a tertiary care hospital. Lung India. 2015;32(3):211–5.CrossRefPubMedPubMedCentral Gupta AA, Sehgal IS, Dhooria S, Singh N, Aggarwal AN, Gupta D, et al. Indications for performing flexible bronchoscopy: Trends over 34 years at a tertiary care hospital. Lung India. 2015;32(3):211–5.CrossRefPubMedPubMedCentral
19.
go back to reference Jin F, Mu D, Chu D, Fu E, Xie Y, Liu T. Severe complications of bronchoscopy. Respiration. 2008;76(4):429–33.CrossRefPubMed Jin F, Mu D, Chu D, Fu E, Xie Y, Liu T. Severe complications of bronchoscopy. Respiration. 2008;76(4):429–33.CrossRefPubMed
20.
go back to reference Heuss LT, Froehlich F, Beglinger C. Nonanesthesiologist-administered propofol sedation: from the exception to standard practice. Sedation and monitoring trends over 20 years. Endoscopy. 2012;44(5):504–11.CrossRefPubMed Heuss LT, Froehlich F, Beglinger C. Nonanesthesiologist-administered propofol sedation: from the exception to standard practice. Sedation and monitoring trends over 20 years. Endoscopy. 2012;44(5):504–11.CrossRefPubMed
21.
go back to reference Stolz D, Kurer G, Meyer A, Chhajed PN, Pflimlin E, Strobel W, et al. Propofol versus combined sedation in flexible bronchoscopy: a randomised non-inferiority trial. Eur Respir J. 2009;34(5):1024–30.CrossRefPubMed Stolz D, Kurer G, Meyer A, Chhajed PN, Pflimlin E, Strobel W, et al. Propofol versus combined sedation in flexible bronchoscopy: a randomised non-inferiority trial. Eur Respir J. 2009;34(5):1024–30.CrossRefPubMed
22.
go back to reference Clarkson K, Power CK, O’Connell F, Pathmakanthan S, Burke CM. A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. Chest. 1993;104(4):1029–31.CrossRefPubMed Clarkson K, Power CK, O’Connell F, Pathmakanthan S, Burke CM. A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. Chest. 1993;104(4):1029–31.CrossRefPubMed
23.
go back to reference Clark G, Licker M, Younossian AB, Soccal PM, Frey JG, Rochat T, et al. Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial. Eur Respir J. 2009;34(6):1277–83.CrossRefPubMed Clark G, Licker M, Younossian AB, Soccal PM, Frey JG, Rochat T, et al. Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial. Eur Respir J. 2009;34(6):1277–83.CrossRefPubMed
24.
go back to reference Crawford M, Pollock J, Anderson K, Glavin RJ, MacIntyre D, Vernon D. Comparison of midazolam with propofol for sedation in outpatient bronchoscopy. Br J Anaesth. 1993;70(4):419–22.CrossRefPubMed Crawford M, Pollock J, Anderson K, Glavin RJ, MacIntyre D, Vernon D. Comparison of midazolam with propofol for sedation in outpatient bronchoscopy. Br J Anaesth. 1993;70(4):419–22.CrossRefPubMed
25.
go back to reference Rex DK, Deenadayalu VP, Eid E, Imperiale TF, Walker JA, Sandhu K, et al. Endoscopist-directed administration of propofol: a worldwide safety experience. Gastroenterology. 2009;137(4):1229–37. quiz 1518-1229.CrossRefPubMed Rex DK, Deenadayalu VP, Eid E, Imperiale TF, Walker JA, Sandhu K, et al. Endoscopist-directed administration of propofol: a worldwide safety experience. Gastroenterology. 2009;137(4):1229–37. quiz 1518-1229.CrossRefPubMed
26.
go back to reference Bosslet GT, Devito ML, Lahm T, Sheski FD, Mathur PN. Nurse-administered propofol sedation: feasibility and safety in bronchoscopy. Respiration. 2010;79(4):315–21.CrossRefPubMed Bosslet GT, Devito ML, Lahm T, Sheski FD, Mathur PN. Nurse-administered propofol sedation: feasibility and safety in bronchoscopy. Respiration. 2010;79(4):315–21.CrossRefPubMed
27.
go back to reference Facciolongo N, Piro R, Menzella F, Lusuardi M, Salio M, Agli LL, et al. Training and practice in bronchoscopy a national survey in Italy. Monaldi Arch Chest Dis. 2013;79(3-4):128–33.CrossRefPubMed Facciolongo N, Piro R, Menzella F, Lusuardi M, Salio M, Agli LL, et al. Training and practice in bronchoscopy a national survey in Italy. Monaldi Arch Chest Dis. 2013;79(3-4):128–33.CrossRefPubMed
28.
go back to reference Ernst A, Wahidi MM, Read CA, Buckley JD, Addrizzo-Harris DJ, Shah PL, et al. Adult Bronchoscopy Training: Current State and Suggestions for the Future: CHEST Expert Panel Report. Chest. 2015;148(2):321–32.CrossRefPubMedPubMedCentral Ernst A, Wahidi MM, Read CA, Buckley JD, Addrizzo-Harris DJ, Shah PL, et al. Adult Bronchoscopy Training: Current State and Suggestions for the Future: CHEST Expert Panel Report. Chest. 2015;148(2):321–32.CrossRefPubMedPubMedCentral
29.
go back to reference Bolliger CT, Mathur PN, Beamis JF, Becker HD, Cavaliere S, Colt H, et al. ERS/ATS statement on interventional pulmonology. European Respiratory Society/American Thoracic Society. Eur Respir J. 2002;19(2):356–73.CrossRefPubMed Bolliger CT, Mathur PN, Beamis JF, Becker HD, Cavaliere S, Colt H, et al. ERS/ATS statement on interventional pulmonology. European Respiratory Society/American Thoracic Society. Eur Respir J. 2002;19(2):356–73.CrossRefPubMed
30.
Metadata
Title
Sedation during bronchoscopy: data from a nationwide sedation and monitoring survey
Authors
Thomas Gaisl
Daniel J. Bratton
Ludwig T. Heuss
Malcolm Kohler
Christian Schlatzer
Marco P. Zalunardo
Martin Frey
Daniel Franzen
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2016
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-016-0275-4

Other articles of this Issue 1/2016

BMC Pulmonary Medicine 1/2016 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.