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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2021

Open Access 01-12-2021 | Sectio Ceasarea | Research article

Oxytocin use in trial of labor after cesarean and its relationship with risk of uterine rupture in women with one previous cesarean section: a meta-analysis of observational studies

Authors: Huan ZHANG, Haiyan LIU, Shouling LUO, Weirong GU

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

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Abstract

Background

Trial of labor after a previous cesarean delivery (TOLAC) has reduced the rate of cesarean sections (CS). Nevertheless, the widespread use of TOLAC has been limited by an increase in adverse outcomes, the most serious one being the risk of symptomatic uterine rupture, which is possibly associated with oxytocin. In this meta-analysis, we explored the risk association between oxytocin use and uterine rupture in TOLAC.

Methods

Multiple electronic databases (PubMed, Embase, Web of Science, and Google Scholar) were searched for cross-sectional studies reporting on TOLAC, oxytocin and uterine rupture, which were published between January 1986 and October 2019. The bias-corrected Hedge’s g was calculated as the effect size using the random-effects model. A two-sample Z test was used to compare the differences in synthetic rates between groups. The Newcastle-Ottawa Scale (NOS) was used to evaluate the risk of bias. Quality of the evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) certainty ratings system.

Results

A total of 14 studies, which included 48,457 women who underwent TOLAC, met the inclusion criteria. The pooled rate of vaginal birth after a cesarean section (VBAC) and the rate of uterine rupture in spontaneous labor were 74.3 and 0.7%, respectively. In addition, the pooled rate of VBAC and the rate of uterine rupture in the induction labor group was 60.7 and 2.2%, respectively. The women who had spontaneous labor had a significantly higher rate of VBAC (p = 0.001) and a lower rate of uterine rupture (p = 0.0003) compared to induced labor. The pooled rates of uterine rupture in women using oxytocin and women not using oxytocin in TOLAC were 1.4% and 0.5%, respectively, and the difference was significant (p = 0.0002). Also, the synthetic rate of uterine rupture in oxytocin augmentation among women with spontaneous labor and women who had a successful induction of labor were 1.7% and 2.2%, respectively, without significant difference (p = 0.443).

Conclusions

Women with induced labor had a higher risk of uterine rupture compared to women with spontaneous labor following TOLAC. Oxytocin use may increase this risk, which could be influenced by the process of induction or individual cervix condition. Consequently, simplified and standardized intrapartum management, precise protocol, and cautious monitoring of oxytocin use in TOLAC are necessary.
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Literature
1.
Pyykönen A, Gissler M, Løkkegaard E, et al. Cesarean section trends in the Nordic countries–a comparative analysis with the Robson classification [J]. Acta Obstet Gynecol Scand. 2017;96(5):607–16.PubMedCrossRef
2.
Blondel B, Lelong N, Kermarrec M, et al. Trends in perinatal health in France between 1995 and 2010: results from the National Perinatal Surveys [J]. J Gynécol Obstét Biol Reprod. 2012;41(2):151–66.CrossRef
3.
American College of Obstetricians and Gynecologists. ACOG Practice bulletin no. 115: Vaginal birth after previous cesarean delivery [J]. Obstet Gynecol. 2010;116(2 Pt 1):450.
4.
5.
Mozurkewich EL, Hutton EK. Elective repeat cesarean delivery versus trial of labor: a meta-analysis of the literature from 1989 to 1999[J]. Am J Obstet Gynecol. 2000;183(5):1187–97.PubMedCrossRef
6.
Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery [J]. N Engl J Med. 2004;351(25):2581–9.PubMedCrossRef
7.
Villar J, Valladares E, Wojdyla D, et al. Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin America [J]. Lancet. 2006;367(9525):1819–29.PubMedCrossRef
8.
9.
Leung AS, Leung EK, Paul RH. Uterine rupture after previous cesarean delivery: maternal and fetal consequences [J]. Am J Obstet Gynecol. 1993;169(4):945–50.CrossRefPubMed
10.
Plauché WC, Von WA, Muller R. Catastrophic uterine rupture [J]. Obstet Gynecol. 1984;64(6):792–7.PubMed
11.
Vaginal delivery after a previous cesarean birth. ACOG Committee opinion. Number 143-October 1994 (replaces No. 64, October 1988). Committee on Obstetric Practice. American College of Obstetricians and Gynecologists [J]. Int J Gynaecol Obstet. 1995;48(1):127-129.
12.
Flamm BL, Anton D, Goings JR, et al. Prostaglandin E2 for cervical ripening: a multicenter study of patients with prior cesarean delivery [J]. Am J Perinatol. 1997;14(03):157–60.PubMedCrossRef
13.
Zelop CM, Shipp TD, Repke JT, et al. Uterine rupture during induced or augmented labor in gravid women with one prior cesarean delivery [J]. Am J Obstet Gynecol. 1999;181(4):882–6.PubMedCrossRef
14.
Johnson C, Oriol N, Flood K. Trial of labor: a study of 110 patients [J]. J Clin Anesth. 1991;3(3):216–8.PubMedCrossRef
15.
Grubb DK, Kjos SL, Paul RH. Latent labor with an unknown uterine scar [J]. Obstet Gynecol. 1996;88(3):351–5.PubMedCrossRef
16.
Leung AS, Farmer RM, Leung EK, et al. Risk factors associated with uterine rupture during trial of labor after cesarean delivery: a case-control study [J]. Am J Obstet Gynecol. 1993;168(5):1358–63.PubMedCrossRef
17.
Locatelli A, Ghidini A, Ciriello E, et al. Induction of labor: comparison of a cohort with uterine scar from previous cesarean section vs. a cohort with intact uterus [J]. J Matern Fetal Neonatal Med. 2006;19(8):471–5.CrossRefPubMed
18.
Lydon-Rochelle M, Holt VL, Easterling TR, et al. Risk of uterine rupture during labor among women with a prior cesarean delivery [J]. N Engl J Med. 2001;345(1):3–8.CrossRefPubMed
19.
Facchinetti F, Giovane CD, Petrella E, et al. Induction of labor in women that had a previous cesarean delivery [J]. J Matern Fetal Neonatal Med. 2015;28(1):55–8.CrossRefPubMed
20.
Parant O. Uterine rupture: prediction, diagnosis et management [J]. J Gynecol Obstet Biol Reprod (Paris). 2012;41(8):803–16.CrossRef
21.
Lipsey MW, Wilson DB. Applied social research methods series; Vol. 49.Practical meta-analysis [M]. Thousand Oaks,  CA,  US: Sage Publications, Inc, 2001.
22.
Wells G A, Shea B, O’connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Department of Epidemiology and Community Medicine, University of Ottawa, Canada [J]. University of Ottawa, Canada: Available at: www. ohri. ca/programs/clinical_epidemiology/oxford. asp, 2012.
23.
24.
Fishel Bartal M, Sibai BM, Ilan H, et al. Trial of labor after cesarean (TOLAC) in women with premature rupture of membranes [J]. J Matern Fetal Neonatal Med. 2019:1–7.
25.
Kiwan R, Al QN. Outcome of vaginal birth after cesarean section: a retrospective comparative analysis of spontaneous versus induced labor in women with one previous cesarean section [J]. Annals of African medicine. 2018;17(3):145.PubMedPubMedCentralCrossRef
26.
Hehir MP, Mackie A, Robson MS. Simplified and standardized intrapartum management can yield high rates of successful VBAC in spontaneous labor [J]. J Matern Fetal Neonatal Med. 2017;30(12):1504–8.CrossRefPubMed
27.
Gobillot S, Ghenassia A, Coston A L, et al. Obstetric outcomes associated with induction of labour after caesarean section [J]. J Gynecol Obstet Hum Reprod. 2018;47(10):539–43.CrossRefPubMed
28.
Stenson D, Wallstrom T, Sjostrand M, et al. Induction of labor in women with a uterine scar [J]. J Matern Fetal Neonatal Med. 2016;29(20):3286–91.PubMed
29.
Ashwal E, Wertheimer A, Aviram A, et al. Prediction of successful trial of labor after cesarean–the benefit of prior vaginal delivery [J]. J Matern Fetal Neonatal Med. 2016;29(16):2665–70.PubMed
30.
Shatz L, Erez O, Novack L, et al. 310: Induction of labor after a prior cesarean delivery lessons from a population based study [J]. Am J Obstet Gynecol. 2012;206(1):S148.
31.
Ouzounian J G, Miller D A, Hiebert C J, et al. Vaginal birth after cesarean section: risk of uterine rupture with labor induction [J]. Am J Perinatol. 2011;28(08): 593–6.PubMedCrossRef
32.
Kwee A, Bots M L, Visser G H A, et al. Obstetric management and outcome of pregnancy in women with a history of caesarean section in the Netherlands [J]. Eur J Obstet Gynecol Reprod Biol. 2007;132(2):171–6.PubMedCrossRef
33.
Lin C, Raynor BD. Risk of uterine rupture in labor induction of patients with prior cesarean section: an inner city hospital experience [J]. Am J Obstet Gynecol. 2004;190(5):1476–8.
34.
Blanchette H, Blanchette M, McCabe J, et al. Is vaginal birth after cesarean safe? Experience at a community hospital [J]. Am J Obstet Gynecol. 2001;184(7):1478–87.PubMedCrossRef
35.
Chua S, Arulkumaran S, Singh P, Ratnam SS. Trial of labour after previous caesarean section: obstetric outcome [J]. Aust N Z J Obstet Gynaecol. 1989;29(1):12–7.PubMedCrossRef
36.
Gregory KD, Korst LM, Fridman M, et al. Vaginal birth after cesarean: clinical risk factors associated with adverse outcome [J]. Am J Obstet Gynecol. 2008;198(4):452–e1 452. e12.PubMedCrossRef
37.
Grinstead J, Grobman WA. Induction of labor after one prior cesarean: predictors of vaginal delivery [J]. Obstet Gynecol. 2004;103(3):534–8.PubMedCrossRef
38.
Grobman WA, Gilbert S, Landon MB, et al. Outcomes of induction of labor after one prior cesarean [J]. Obstet Gynecol. 2007;109(2):262–9.PubMedCrossRef
39.
Guise JM, Hashima J, Osterweil P. Evidence-based vaginal birth after caesarean section [J]. Best Pract Res Clin Obstet Gynaecol. 2005;19(1):117–30.CrossRefPubMed
40.
Guise JM, McDonagh M, Hashima J, et al. Vaginal birth after cesarean (VBAC)[J]. Evid Rep Technol Assess. 2003;71:1–188.
41.
Cunningham F, Leveno K, Bloom S, et al. Williams Obstetrics, vol. 872. 23rd ed. N Y: McGraw Hill [J]; 2010.
42.
Lundgren I, Begley C, Gross MM, et al. Groping through the fog’: a metasynthesis of women's experiences on VBAC (Vaginal birth after Caesarean section)[J]. BMC Pregnancy Childbirth. 2012;12(1):85.PubMedPubMedCentralCrossRef
43.
Peaceman AM, Gersnoviez R, Landon MB, et al. The MFMU cesarean registry: impact of fetal size on trial of labor success for patients with previous cesarean for dystocia [J]. Am J Obstet Gynecol. 2006;195(4):1127–31.CrossRefPubMed
44.
Deruelle P, Lepage J, Depret S, et al. Induction of labor and intrapartum management for women with uterine scar [J]. J Gynecol Obstet Biol Reprod (Paris). 2012;41(8):788–802.CrossRef
45.
Hoffman MK, Grant GH. Induction of labor in women with a prior cesarean delivery [C]//seminars in perinatology. WB Saunders. 2015;39(6):471–4.
46.
Sananès N, Rodriguez M, Stora C, et al. Efficacy and safety of labour induction in patients with a single previous caesarean section: a proposal for a clinical protocol [J]. Arch Gynecol Obstet. 2014;290(4):669–76.CrossRefPubMed
47.
Goetzl L, Shipp TD, Cohen A, et al. Oxytocin dose and the risk of uterine rupture in trial of labor after cesarean [J]. Obstet Gynecol. 2001;97(3):381–4.PubMed
48.
Cahill AG, Stamilio DM, Odibo AO, et al. Does a maximum dose of oxytocin affect risk for uterine rupture in candidates for vaginal birth after cesarean delivery?[J]. Am J Obstet Gynecol. 2007;197(5):495–e1 495. e5.CrossRefPubMed
49.
Cahill AG, Waterman BM, Stamilio DM, et al. Higher maximum doses of oxytocin are associated with an unacceptably high risk for uterine rupture in patients attempting vaginal birth after cesarean delivery [J]. Am J Obstet Gynecol. 2008;199(1):32–e1 32. e5.CrossRefPubMed
50.
Macones GA, Peipert J, Nelson DB, et al. Maternal complications with vaginal birth after cesarean delivery: a multicenter study [J]. Am J Obstet Gynecol. 2005;193(5):1656–62.PubMedCrossRef
51.
Lewis S, Collins M. Induction of vaginal birth after cesarean using intracervical Foley bulb [J]. J Midwifery Womens Health. 2008;53(6):563–6.PubMedCrossRef
52.
Harper LM, Cahill AG, Boslaugh S, et al. Association of induction of labor and uterine rupture in women attempting vaginal birth after cesarean: a survival analysis [J]. Am J Obstet Gynecol. 2012;206(1):51–e1 51. e5.PubMed
53.
Leduc D, Biringer A, Lee L, et al. Déclenchement du travail [J]. J Obstet Gynaecol Can. 2013;35(9):858–63.CrossRef
54.
Radan AP, Amylidi SK, Mosimann B, et al. Safety and effectiveness of labour induction after caesarean section using balloon catheter or oxytocin [J]. Swiss Med Wkly. 2017;147:w14532.PubMed
Metadata
Title
Oxytocin use in trial of labor after cesarean and its relationship with risk of uterine rupture in women with one previous cesarean section: a meta-analysis of observational studies
Authors
Huan ZHANG
Haiyan LIU
Shouling LUO
Weirong GU
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-020-03440-7

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