Top

BMC Pregnancy and Childbirth

Published in:

Open Access 01-12-2021 | Estradiol | Research article

The predictive value of serial serum estradiol and serial endometrial volume on endometrial receptivity on assisted reproductive technology cycles

Authors: R. Silva Martins, A. Helio Oliani, D. Vaz Oliani, J. Martinez de Oliveira

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

Abstract

Background

Diagnosis of endometrial receptivity is still unclear and conflicting. Despite advances in embryo development during assisted reproductive technologies (ART) cycles, the intricate process of implantation is still matter for debate and research.

Materials and methods

Prospective case control of 169 subjects during ovarian controlled stimulation for ART. Endometrial receptivity assessment to predict clinical pregnancy with serial continuous biochemical (serum estradiol) and biophysical (endometrial volume and adjusted endometrial volume) parameters were used. Both parameters were compared between negative and positive outcome in terms of clinical pregnancy.

Results

No statistical difference was noted between the two groups in terms of demographics and ART procedures and scores. Serum estradiol was significantly higher in the positive group from day 8 after ovarian controlled stimulation. Endometrial volume and adjusted endometrial volume were significantly higher in the positive group as soon as day 6 of ovarian controlled stimulation.

Conclusions

Continuous serum estradiol and 3D endometrial volume and adjusted endometrial volumes may reflect endometrial changes during ART procedures and provide a useful real time tool for clinicians in predicting endometrial receptivity.

Ullah K, Rahman TU, Pan HT, Guo MX, Dong XY, Liu J, Jin LY, Cheng Y, Ke ZH, Ren J, Lin XH, Qiu XX, Wang TT, Huang HF, Sheng JZ. Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium. J Mol Endocrinol. 2017;59(2):105–19. https://doi.org/10.1530/JME-17-0036.CrossRefPubMedPubMedCentral

Song J, Sun X, Qian K. Endometrial but not ovarian response is associated with clinical outcomes and can be improved by prolonged pituitary downregulation in patients with thin and medium endometrium. Reprod Sci. 2019;26(11):1409–16. https://doi.org/10.1177/1933719118816835.CrossRefPubMed

Cottrell HN, Deepak V, Spencer JB, Sideel N, Rajakumar A. Effects of supraphysiological levels of estradiol on endometrial decidualization, sFlt1 and HOXA10 expression. Reprod Sci. 2019;26(12):1626–32. https://doi.org/10.1177/1933719119833485.CrossRefPubMed

Wang H, Shi G, Li M, Fan H, Ma H, Sheng L. Correlation of IL-1 and HB-EGF with endometrial receptivity. Exp Ther Med. 2018;16(6):5130–6. https://doi.org/10.3892/etm.2018.6840.CrossRefPubMedPubMedCentral

Xu X, Ding J, Rao G, Shen J, Prinz RA, Rana N, Dmowski WP. Estradiol induces heparinase-1 expression and heparan sulphate proteoglycan degradation in human endometrium. Hum Reprod. 2007;22(4):927–37. https://doi.org/10.1093/humrep/del483.CrossRefPubMed

Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy A. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Repro Update. 2019;25(2):2020–223. https://doi.org/10.1093/humupd/dmy044.CrossRef

Paulson RJ. Hormonal induction of endometrial receptivity. Fertil Steril. 2011;96(3):530–5. https://doi.org/10.1016/jfertnstert.2011.07.1097.CrossRefPubMed

Altmae S, Mantinez-Conejero JA, Salumets A, Simon C, Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod. 2010;16:178–87.CrossRef

Simon C, Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F. Understanding and improving endometrial receptivity. Curr Opin Obstet Gunecol. 2015;27(3):187–92. https://doi.org/10.1097/GCO.0000000000000173.CrossRef

10.

Simon C, Bellever J. Implantation failure of endometrial origin: what is new? Curr Opin Obstet Gynecol. 2018;30(4):229–36. https://doi.org/10.1097/GCO.0000000000000468.CrossRefPubMed

11.

Mirkin S, Arslan M, Churikov D, Corica A, Diaz JI, Williamns S, Bocca S, Oehninger S. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum Reprod. 2005;20(8):2140–17. https://doi.org/10.1093/humrep/dei051.CrossRef

12.

Sharara FI, Lim J, McClamrock HD. Endometrial pattern on the day of oocyte retrieval is more predictive of implantation success than the patterns or thickness on the day of hCG administration. J Assist Reprod Genet. 1999;16(10):523–8. https://doi.org/10.1023/a:1020545120256.CrossRefPubMedPubMedCentral

13.

Lessey BA. Assessment of endometrial receptivity. Fertil Steril. 2011;96:522–9.CrossRef

14.

Lessey BA. The pathologists are free to go, or are they? Fertile Steril. 2013;99:350–1.CrossRef

15.

Sher G, Dodge S, Maassarani G, Knutzen V, Zouves C, Feinman M. Management of suboptimal sonographic endometrial patterns in patients undergoing in-vitro fertilization and embryo transfer. Hum Reprod. 1993;8(3):347–9.CrossRef

16.

Mains L, Van Voohirs BJ. Optimizing the technique of embryo transfer. Fertile Steril. 2010;94:785–90.CrossRef

17.

Silva Martins R, Helio Oliani A, Vaz Oliani D, Martinez de Oliveira J. Subendometrial resistence and pulsatility index assessment of endometrial receptivity in assisted reproductive technology cycles. Reprod Biol Endocrinol. 2019;17(1):62. https://doi.org/10.1186/s12958-019-0507-6.CrossRefPubMedPubMedCentral

18.

Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update. 2003;9:515–22.CrossRef

19.

Hou Z, Zhang Q, Zhao J, Xu A, He A, Huang X, Xie S, Fu J, Xiao L, Li Y. 2019 value of endometrial echo pattern transformation after hCG trigger in predicting IVF pregnancy outcome: a prospective cohort study. Reprod Biol Endocrinol. 2019;74. https://doi.org/10.1186/s12958-019-0516-5.

20.

Navot D, Bergh PA, Williams MA, Garrisi GJ, Guzman I, Sandler B, Grunfeld L. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet. 1991;337:1375–7.CrossRef

21.

Fatemi HM, Popovic-Teodorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod Biomed Online. 2013;27:530–8.CrossRef

Title: The predictive value of serial serum estradiol and serial endometrial volume on endometrial receptivity on assisted reproductive technology cycles
Authors: R. Silva Martins
A. Helio Oliani
D. Vaz Oliani
J. Martinez de Oliveira
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Estradiol
Published in: BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-021-03672-1

2024 ASCO Annual Meeting

Springer Medicine

The predictive value of serial serum estradiol and serial endometrial volume on endometrial receptivity on assisted reproductive technology cycles

Abstract

Background

Materials and methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2021

Stress, anxiety, and depression in infertile couples are not associated with a first IVF or ICSI treatment outcome

Explaining the impact of mHealth on maternal and child health care in low- and middle-income countries: a realist synthesis

A woman with disseminated tuberculosis experienced preterm delivery, fallopian tube pregnancy, and delivered successfully following in vitro fertilization: a case report

Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol

Nomogram for perinatal prediction of intrapartum fever: a retrospective case–control study

Causes of preterm and low birth weight neonatal mortality in a rural community in Kenya: evidence from verbal and social autopsy