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Pediatric Radiology

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19-05-2023 | Scoliosis | Original Article

MRI features of spinal chronic recurrent multifocal osteomyelitis/chronic non-bacterial osteomyelitis in children

Authors: Andressa Guariento, Parth Sharma, Savvas Andronikou

Published in: Pediatric Radiology | Issue 10/2023

Abstract

Background

Spinal lesions in pediatric chronic recurrent multifocal osteomyelitis/chronic non-bacterial osteomyelitis (CRMO/CNO) can cause permanent sequelae; thus, early recognition of these is vital for management.

Objective

To characterize the MR imaging features and patterns of pediatric spinal CRMO/CNO.

Materials and methods

This cross-section study received IRB approval. The first available MRI with documented spine involvement in children with CRMO/CNO was reviewed by a pediatric radiologist. Descriptive statistics were used to describe the characteristics of vertebral lesions, disc involvement, and soft tissue abnormality.

Results

Forty-two patients were included (F:M, 30:12); median age was 10 years (range 4–17). At diagnosis, 34/42 (81%) had spine involvement. Kyphosis in 9/42 (21%) and scoliosis in 4/42 (9.5%) patients were present at the time of spinal disease recognition. Vertebral involvement was multifocal in 25/42 (59.5%). Disc involvement was found in 11/42 (26%) patients, commonly in the thoracic spine and often with adjacent vertebrae height loss. Posterior element abnormalities were present in 18/42 patients (43%) and soft tissue involvement in 7/42 (17%). One hundred nineteen vertebrae were affected, commonly the thoracic vertebrae (69/119; 58%). Vertebral body edema was focal in 77/119 (65%) and frequently superior (42/77; 54%). Sclerosis and endplate abnormality were present in 15/119 (13%) and 31/119 (26%) vertebrae, respectively. Height loss was present in 41/119 (34%).

Conclusion

Chronic non-bacterial osteomyelitis of spine is usually thoracic. Vertebral body edema is often focal at the superior vertebral body. Kyphosis and scoliosis occur in a quarter and vertebral height loss in a third of children at spinal disease recognition.

Graphical Abstract

Available only for authorised users

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Title: MRI features of spinal chronic recurrent multifocal osteomyelitis/chronic non-bacterial osteomyelitis in children
Authors: Andressa Guariento
Parth Sharma
Savvas Andronikou
Publication date: 19-05-2023
Publisher: Springer Berlin Heidelberg
Keywords: Scoliosis
Vertebra Plana
Edema
Osteomyelitis
Published in: Pediatric Radiology / Issue 10/2023
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-023-05688-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MRI features of spinal chronic recurrent multifocal osteomyelitis/chronic non-bacterial osteomyelitis in children

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Graphical Abstract

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