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01-08-2019 | Schizophrenia | Original Article

Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms

Authors: Lingling Cui, Fei Wang, Miao Chang, Zhiyang Yin, Guoguang Fan, Yanzhuo Song, Yange Wei, Yixiao Xu, Yifan Zhang, Yanqing Tang, Xiaohong Gong, Ke Xu

Published in: Neuroscience Bulletin | Issue 4/2019

Abstract

ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Here, we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants. Amplitudes of low-frequency fluctuations (ALFFs) were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680. The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 × COMT rs4680 interaction, manifesting as a U-shaped modulation, presumably by dopamine signaling. Significant main effects were also found. These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT, and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.

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Title: Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms
Authors: Lingling Cui
Fei Wang
Miao Chang
Zhiyang Yin
Guoguang Fan
Yanzhuo Song
Yange Wei
Yixiao Xu
Yifan Zhang
Yanqing Tang
Xiaohong Gong
Ke Xu
Publication date: 01-08-2019
Publisher: Springer Singapore
Keyword: Schizophrenia
Published in: Neuroscience Bulletin / Issue 4/2019
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-019-00357-w

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Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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