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06-09-2023 | Schizophrenia | Original Article

Sex difference in association between cognitive and P50 deficits in patients with chronic schizophrenia

Authors: Dongmei Wang, Luyao Xia, Zhiqi Zhang, Mehmet A. Camkurt, Aaron Issac, Emily Wu, Meihong Xiu, Dachun Chen, Xiang-Yang Zhang

Published in: Archives of Women's Mental Health | Issue 6/2023

Abstract

A large number of studies have reported that sensory gating disorders represented by P50 inhibition may be involved in the pathophysiological process of schizophrenia. However, few studies have explored the relationship between sensory gating disorders and cognitive dysfunction in patients with schizophrenia. This study aimed to explore sex differences in the relationship between cognitive and P50 deficits in patients with chronic schizophrenia, which has not been reported. A total of 183 chronic schizophrenia patients (128 males and 55 females) and 166 healthy controls (76 males and 90 females) participated in this study. The MATRICS Consensus Cognitive Battery (MCCB) was measured for cognitive function and P50 components for the sensory gating in all participants. The Positive and Negative Syndrome Scales (PANSS) was used to assess the psychopathological symptoms in patients. Female patients performed significantly better than male patients in several cognitive domains of MCCB (all p < 0.01). There were no significant differences in P50 components between male and female patients (all p > 0.05). Further analysis showed that in female patients, latency of S2 was negatively correlated with reasoning and problem-solving domain of MCCB (p < 0.05), and P50 ratio was negatively correlated with social cognition domain of MCCB (p < 0.05). In male patients, there was no any correlation between P50 and cognitive domains of MCCB. Our results suggest that there is a sex difference in the association between P50 deficiency and cognitive impairment in Chinese Han patients with schizophrenia.

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Title: Sex difference in association between cognitive and P50 deficits in patients with chronic schizophrenia
Authors: Dongmei Wang
Luyao Xia
Zhiqi Zhang
Mehmet A. Camkurt
Aaron Issac
Emily Wu
Meihong Xiu
Dachun Chen
Xiang-Yang Zhang
Publication date: 06-09-2023
Publisher: Springer Vienna
Keyword: Schizophrenia
Published in: Archives of Women's Mental Health / Issue 6/2023
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-023-01367-4

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Sex difference in association between cognitive and P50 deficits in patients with chronic schizophrenia

Abstract

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Springer Medicine

Abstract

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