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European Archives of Psychiatry and Clinical Neuroscience

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01-06-2020 | Schizophrenia | Short Communication

Reduced Annexin A3 in schizophrenia

Authors: Helena P. G. Joaquim, Alana Caroline Costa, Maurício Henriques Serpa, Leda L. Talib, Wagner F. Gattaz

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 4/2020

Abstract

The cellular and molecular mechanisms underlying onset and development of schizophrenia have not yet been completely elucidated, but the association of disturbed neuroplasticity and inflammation has gained particular relevance recently. These mechanisms are linked to annexins functions. ANXA3, particularly, is associated to inflammation and membrane metabolism cascades. The aim was to determine the ANXA3 levels in first-onset drug-naïve psychotic patients. We investigated by western blot the protein expression of annexin A3 in platelets of first-onset, drug-naïve psychotic patients (diagnoses according to DSM-IV: 28 schizophrenia, 27 bipolar disorder) as compared to 30 age- and gender-matched healthy controls. Annexin A3 level was lower in schizophrenia patients as compared to healthy controls (p < 0.001) and to bipolar patients (p < 0.001). Twenty out of 28 schizophrenic patients had undetectable annexin A3 levels, as compared to none from the bipolar and none from the control subjects. ANXA3 was reduced in drug-naïve patients with schizophrenia. ANXA3 affects neuroplasticity, inflammation and apoptosis, as well as it modulates membrane phospholipid metabolism. All these processes have been discussed in regard to the biology of schizophrenia. In face of these data, we feel that further studies with larger samples are warranted to investigate the possible role of reduced ANXA3 as a possible risk marker for schizophrenia.

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Title: Reduced Annexin A3 in schizophrenia
Authors: Helena P. G. Joaquim
Alana Caroline Costa
Maurício Henriques Serpa
Leda L. Talib
Wagner F. Gattaz
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keyword: Schizophrenia
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 4/2020
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-019-01048-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reduced Annexin A3 in schizophrenia

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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