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European Archives of Psychiatry and Clinical Neuroscience

25-04-2024 | Schizophrenia | Original Paper

Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia

Authors: Biying Ye, Yiqiao Wu, Mingjun Cao, Chanhuan Xu, Chao Zhou, Xiangrong Zhang

Published in: European Archives of Psychiatry and Clinical Neuroscience

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Abstract

This study aims to investigate the altered patterns of dynamic functional network connectivity (dFNC) between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and further explore the associations with cognitive impairments. 70 DS, 91 NDS, and 120 matched healthy controls (HCs) were enrolled. The independent component analysis was used to segment the whole brain. The fMRI brain atlas was used to identify functional networks, and the dynamic functional connectivity (FC) of each network was detected. Correlation analysis was used to explore the associations between altered dFNC and cognitive functions. Four dynamic states were identified. Compared to NDS, DS showed increased FC between sensorimotor network and default mode network in state 1 and decreased FC within auditory network in state 4. Additionally, DS had a longer mean dwell time of state 2 and a shorter one in state 3 compared to NDS. Correlation analysis showed that fraction time and mean dwell time of states were correlated with cognitive impairments in DS. This study demonstrates the distinctive altered patterns of dFNC between DS and NDS patients. The associations with impaired cognition provide specific neuroimaging evidence for the pathogenesis of DS.
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Metadata
Title
Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia
Authors
Biying Ye
Yiqiao Wu
Mingjun Cao
Chanhuan Xu
Chao Zhou
Xiangrong Zhang
Publication date
25-04-2024
Publisher
Springer Berlin Heidelberg
Keyword
Schizophrenia
Published in
European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-024-01803-1