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BMC Psychiatry

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01-12-2021 | Schizophrenia | Research

Cortical thickness distinguishes between major depression and schizophrenia in adolescents

Authors: Zheyi Zhou, Kangcheng Wang, Jinxiang Tang, Dongtao Wei, Li Song, Yadong Peng, Yixiao Fu, Jiang Qiu

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

Early diagnosis of adolescent psychiatric disorder is crucial for early intervention. However, there is extensive comorbidity between affective and psychotic disorders, which increases the difficulty of precise diagnoses among adolescents.

Methods

We obtained structural magnetic resonance imaging scans from 150 adolescents, including 67 and 47 patients with major depressive disorder (MDD) and schizophrenia (SCZ), as well as 34 healthy controls (HC) to explore whether psychiatric disorders could be identified using a machine learning technique. Specifically, we used the support vector machine and the leave-one-out cross-validation method to distinguish among adolescents with MDD and SCZ and healthy controls.

Results

We found that cortical thickness was a classification feature of a) MDD and HC with 79.21% accuracy where the temporal pole had the highest weight; b) SCZ and HC with 69.88% accuracy where the left superior temporal sulcus had the highest weight. Notably, adolescents with MDD and SCZ could be classified with 62.93% accuracy where the right pars triangularis had the highest weight.

Conclusions

Our findings suggest that cortical thickness may be a critical biological feature in the diagnosis of adolescent psychiatric disorders. These findings might be helpful to establish an early prediction model for adolescents to better diagnose psychiatric disorders.

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Title: Cortical thickness distinguishes between major depression and schizophrenia in adolescents
Authors: Zheyi Zhou
Kangcheng Wang
Jinxiang Tang
Dongtao Wei
Li Song
Yadong Peng
Yixiao Fu
Jiang Qiu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Schizophrenia
Affective Disorder
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03373-1

At a glance: The STEP trials

Springer Medicine

Cortical thickness distinguishes between major depression and schizophrenia in adolescents

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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Other articles of this Issue 1/2021

The first experimental study of transference work–in teenagers (FEST–IT): a multicentre, observer- and patient-blind, randomised controlled component study

Cognitive control and emotional response in attention-deficit/ hyperactivity disorder comorbidity with disruptive, impulse-control, and conduct disorders

Is preexisting mental illness associated with lower patient satisfaction for older trauma patients? A cross-sectional descriptive study

Full and partial posttraumatic stress disorders in adults exposed to super typhoon Lekima: a cross-sectional investigation

Longitudinal influence of COVID-19-related stress on sexual compulsivity symptoms in Chinese undergraduates

Clinical characteristic of prodromal symptoms between bipolar I and II disorder among Chinese patients: a retrospective study