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20-12-2022 | SARS-CoV-2 | Im - Original

Serological response to COVID-19 pneumonia and increasing severity over 18 months in a prospective cohort of hospitalized patients

Authors: Gemma Grau Gómez, Xavier Martínez Lacasa, Roser Costa, Bienvenido Barreiro, Miguel Leal, Emma Padilla, Pepa Pérez, Marc Garreta, Judith Vidal, Angeles Jaen, Helena Monzón Camps, COMUTE Study Group (COVID-19 Mutua Terrassa Study Group)

Published in: Internal and Emergency Medicine | Issue 2/2023

Abstract

In this study, we present an 18-month serological follow-up of 294 patients with COVID-19 pneumonia. The aim was to assess the dynamics of serological response and its correlation with clinical worsening, as well as to describe clinical worsening determinants. Results of the study showed an early immunoglobulin M response, which clearly diminished starting at 4 months, but nonetheless, a small group of patients remained positive. As for immunoglobulin G, levels were higher up to 6 months in patients who presented clinical worsening during hospitalization. High titers of the immunoglobulin were maintained in all patients during follow-up, which would indicate that humoral immunity due to infection is long-lasting. Male sex, presence of myalgias and extensive radiological affectation were significantly correlated with clinical worsening.

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Title: Serological response to COVID-19 pneumonia and increasing severity over 18 months in a prospective cohort of hospitalized patients
Authors: Gemma Grau Gómez
Xavier Martínez Lacasa
Roser Costa
Bienvenido Barreiro
Miguel Leal
Emma Padilla
Pepa Pérez
Marc Garreta
Judith Vidal
Angeles Jaen
Helena Monzón Camps
COMUTE Study Group (COVID-19 Mutua Terrassa Study Group)
Publication date: 20-12-2022
Publisher: Springer International Publishing
Keywords: SARS-CoV-2
Pneumonia
COVID-19
Published in: Internal and Emergency Medicine / Issue 2/2023
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-022-03177-5

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