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01-04-2021 | SARS-CoV-2 | Review

Perinatal COVID-19: review of current evidence and practical approach towards prevention and management

Authors: Venkateshwarlu Vardhelli, Aakash Pandita, Anish Pillai, Susanta Kumar Badatya

Published in: European Journal of Pediatrics | Issue 4/2021

Abstract

The clinical spectrum of the perinatal COVID-19 and prospective data on neonatal outcomes remains largely unexplored. Most of the existing literature is in the form of case series or single-centre experience. In this review, we aim to summarize available literature on the clinical spectrum of COVID-19 in neonates and mothers and suggest a practical approach towards management of clinical scenarios. This review explores the clinical characteristics and outcomes of COVID-19 in neonates born to mothers who were detected with the virus during the pregnancy. We conducted a comprehensive search of PubMed, Google Scholar and Cochrane Database of Systematic Review between November 2019 and June 2020 and screened articles related to perinatal COVID-19. This review included 786 mothers, among which 64% (504) were delivered by caesarian section. There were 3 still births and 107 (14%) were delivered preterm. Out of 793 neonates born, 629 neonates (79%) were tested after birth. The commonest symptom in neonates was respiratory distress. Respiratory support was needed in 60 neonates (7.6%), with 14 babies needing mechanical ventilation (1.8%), 25 needing non-invasive ventilation and 21 needing nasal oxygen. Only 35 of the 629 tested neonates (5.5%) were positive for COVID-19. Of the 35 positive neonates, 14 (40%) were symptomatic. The COVID-19 seems to have favourable neonatal outcomes. Majority of neonates are asymptomatic. Respiratory distress is the most common manifestation.

What is known: •COVID-19 affects all ages. •Neonatal disease is usually mild.
What is new: •Vertical transmission is a possible route of infection in neonates. •Breast milk and skin-to-skin contact are safe in COVID-19-infected mothers if performed with appropriate use of precautions such as hand and breast hygiene and masking.

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Title: Perinatal COVID-19: review of current evidence and practical approach towards prevention and management
Authors: Venkateshwarlu Vardhelli
Aakash Pandita
Anish Pillai
Susanta Kumar Badatya
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Keywords: SARS-CoV-2
COVID-19
Published in: European Journal of Pediatrics / Issue 4/2021
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-020-03866-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Perinatal COVID-19: review of current evidence and practical approach towards prevention and management

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

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