Published in:
01-10-2021 | SARS-CoV-2 | COVID-19 in Intensive Care
Delirium in COVID-19: can we make the unknowns knowns?
Authors:
M. Elizabeth Wilcox, Manu Shankar-Hari, Daniel F. McAuley
Published in:
Intensive Care Medicine
|
Issue 10/2021
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Excerpt
Delirium is an important public health problem. It is independently associated with worse clinical outcomes, including persistent cognitive impairment, increased mortality, and greater risk of institutionalization [
1]. The prevalence of delirium is high in the intensive care unit (ICU), occurring in up to 70% of the sickest patients requiring mechanical ventilation [
1]. Early studies in hospitalized patients with coronavirus disease 2019 (COVID-19) report delirium rates of 20–30%, which increase to 60–70% in severe illness [
1]. An international multicenter cohort study that included 69 adult ICUs across 14 countries of 2088 COVID-19 patients reported that over a 21-day period, delirium had a prevalence of 55% and lasted a median of 3 days (IQR, 2–6 days) [
2], which is more common and prolonged than that in non-COVID cohorts. …