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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 4/2023

07-03-2023 | Sarcopenia | Invited Commentary

Muscle Mass Effect: The Importance of Diagnosing and Treating Sarcopenia in Patients with Advanced Chronic Liver Disease

Author: Rafael Paternostro

Published in: Digestive Diseases and Sciences | Issue 4/2023

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Excerpt

Throughout the past decade, research on and awareness of sarcopenia (reduced muscle mass) in patients with advanced chronic liver disease (ACLD) have increased among hepatologists, with several recent publications reporting its prevalence, impact on hepatic outcomes, and diagnostic modalities. Sarcopenia, highly prevalent in ACLD patients, negatively impacts hepatic outcomes of patients on and off the liver transplant waiting list [1, 2]. Most importantly, inferior outcomes appear to be independent of the degrees of synthetic dysfunction and/or portal hypertension [3], suggesting that sarcopenia itself might be an important treatment target in improving clinical outcomes in ACLD patients. …
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Tandon P, Ney M, Irwin I et al. Severe muscle depletion in patients on the liver transplant wait list: its prevalence and independent prognostic value. Liver Transpl. 2012;18:1209–1216.CrossRefPubMed
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Praktiknjo M, Book M, Luetkens J et al. Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis. Hepatology. 2018;67:1014–1026.CrossRefPubMed
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Sinclair M, Grossmann M, Hoermann R et al. Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: A randomised controlled trial. J Hepatol. 2016;65:906–913.CrossRefPubMed
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Pedraza-Vázquez G, Mena-Montes B, Hernández-Álvarez D et al. A low-intensity lifelong exercise routine changes miRNA expression in aging and prevents osteosarcopenic obesity by modulating inflammation. Arch Gerontol Geriatr. 2023;105:104856.CrossRefPubMed
Metadata
Title
Muscle Mass Effect: The Importance of Diagnosing and Treating Sarcopenia in Patients with Advanced Chronic Liver Disease
Author
Rafael Paternostro
Publication date
07-03-2023
Publisher
Springer US
Keyword
Sarcopenia
Published in
Digestive Diseases and Sciences / Issue 4/2023
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-023-07864-x

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