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Open Access 01-06-2020 | Sarcopenia | Original Article

Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients

Authors: Dagmar Schaffler-Schaden, Christof Mittermair, Theresa Birsak, Michael Weiss, Tobias Hell, Gottfried Schaffler, Helmut Weiss

Published in: Langenbeck's Archives of Surgery | Issue 4/2020

Abstract

Purpose

Progressive loss (sarcopenia) and fatty infiltration of muscle mass (myosteatosis) are well-established risk factors for an adverse clinical outcome in obese patients. Data concerning non-obese sarcopenic patients in oncologic surgery are scarce and heterogeneous. The aim of this study was to determine the impact of sarcopenia and myosteatosis in non-obese patients with cancer of the right colon on clinical outcome.

Methods

This study comprised 85 patients with a BMI < 30 kg/m², who underwent surgery for right colon cancer in a single center. Skeletal muscle area (SMA), visceral fat area (VFA), and myosteatosis were retrospectively assessed using preoperative abdominal CT images. Univariate und multivariate analysis was performed to evaluate the association between body composition, complications, and oncologic follow-up.

Results

Traditional risk factors such as visceral fat (p = 0.8653), BMI (p = 0.8033), myosteatosis (p = 0.7705), and sarcopenia (p = 0.3359) failed to show any impact on postoperative complications or early recurrence. In our cohort, the skeletal muscle index (SMI) was the only significant predictor for early cancer recurrence (p = 0.0467).

Conclusion

SMI is a significant prognostic factor for early cancer recurrence in non-obese colon cancer patients. Our study shows that conventional thresholds for sarcopenia and BMI do not seem to be reliable across various cohorts. Target prehabilitation programs could be useful to improve outcome after colorectal surgery.

Trial Registration

DRKS00014655, www.apps.who.int/trialsearch

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Title: Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients
Authors: Dagmar Schaffler-Schaden
Christof Mittermair
Theresa Birsak
Michael Weiss
Tobias Hell
Gottfried Schaffler
Helmut Weiss
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Sarcopenia
Colon Cancer
Colon Cancer
Published in: Langenbeck's Archives of Surgery / Issue 4/2020
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-020-01901-3

At a glance: The STEP trials

Springer Medicine

Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients

Abstract

Purpose

Methods

Results

Conclusion

Trial Registration

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Trial Registration

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