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International Journal of Colorectal Disease

Published in:

01-06-2016 | Original Article

Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer

Authors: B. C. Boer, F. de Graaff, M. Brusse-Keizer, D. E. Bouman, C. H. Slump, M. Slee-Valentijn, J. M. Klaase

Published in: International Journal of Colorectal Disease | Issue 6/2016

Abstract

Background

The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic factors for postoperative complications and survival in patients with resectable colon cancer.

Methods

We conducted a retrospective chart review of 91 consecutive patients who underwent an elective open colon resection for cancer with primary anastomosis between 2011 and 2013. Skeletal muscle mass was measured as total psoas area (TPA) and total abdominal muscle area (TAMA) at three anatomical levels on the preoperative CT scan. Skeletal muscle quality was measured using corresponding mean Hounsfield units (HU) for TAMA. Their relation with complications (none vs one or more), severe complications, and survival was analyzed.

Results

The study included 91 patients with a mean age of 71.2 ± 9.7 years. Complications were noted in 55 patients (60 %), of which 15 (16.4 %) were severe. Lower HU for TAMA, as an indicator for impaired skeletal muscle quality, was an independent risk factor for one or more complications (all P ≤ 0.002), while sarcopenic obesity (TPA) was an independent risk factor for severe complications (all P ≤ 0.008). Sarcopenia was an independent predictor of worse overall survival (HR 8.54; 95 % confidence interval (CI) 1.07–68.32).

Conclusion

Skeletal muscle quality is a predictor for overall complications, whereas sarcopenic obesity is a predictor for severe postoperative complications after open colon resection for cancer. Sarcopenia on itself is a predictor for worse overall survival.

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Title: Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer
Authors: B. C. Boer
F. de Graaff
M. Brusse-Keizer
D. E. Bouman
C. H. Slump
M. Slee-Valentijn
J. M. Klaase
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 6/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-016-2538-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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