Top

Published in:

01-06-2010 | Case Report

SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature

Authors: Keith Siau, Catherine J. Laversuch

Published in: Rheumatology International | Issue 8/2010

Abstract

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare group of sterile, inflammatory osteoarticular disorders classically associated with skin lesions. It is occasionally associated with enteropathic disease such as ulcerative colitis. We present a 39-year-old patient with chronic ulcerative colitis who developed enteropathic SAPHO and responded well to pamidronate. We discuss the clinicopathological features with particular attention to bone pathology, and perform a literature review of this fascinating syndrome.

Chamot AM et al (1987) Le syndrome acnè pustulose hyperostose ostèite (SAPHO)—Resultats d’une enquète nationale. Rev Rheumat 54:187–196

Kahn MF, Khan MA (1994) The SAPHO-syndrome. Baillieres Clin Rheumatol 8(2):333–362. doi:10.1016/S0950-3579(94)80022-7 CrossRefPubMed

Hayem G, Bouchaud-Chabot A, Benali K et al (1999) SAPHO syndrome: a long-term follow-up study of 120 cases. Semin Arthritis Rheum 29:159–171. doi:10.1016/S0049-0172(99)80027-4 CrossRefPubMed

Kotilainen P, Merilahti-Palo R, Lehtonen OP et al (1996) Propionibacterium acnes isolated from sternal osteitis in a patient with SAPHO syndrome. J Rheumatol 23(7):1302–1304PubMed

Steinoff JP, Cilursu A, Falasa G et al (2002) A study of musculoskeletal manifestations in 12 patients with SAPHO syndrome. J Clin Rheumatol 8:13–22. doi:10.1097/00124743-200202000-00005 CrossRef

Benhamou CL, Chamot AM, Kahn MF (1988) Synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome (SAPHO): a new syndrome among the spondyloarthropathies? Clin Exp Rheumatol 6:109–112PubMed

Kahn MF, Bouchon JP, Chamot AM, Palazzo E (1992) Enterocolopathies chroniques et syndrome SAPHO. Rev Rheum Mal Osteoartic 59:91–94

Schilling F, Marker-Hermann E (2003) Chronic recurrent multifocal osteomyelitis in association with chronic inflammatory bowel disease: enteropathic CRMO. Z Rheumatol 62:527–538. doi:10.1007/s00393-003-0526-7 CrossRefPubMed

Bousvaros A, Marcon M, Treem W et al (1999) Chronic recurrent multifocal osteomyelitis associated with chronic inflammatory bowel disease in children. Dig Dis Sci 44:2500–2507. doi:10.1023/A:1026695224019 CrossRefPubMed

10.

Schilling F (2004) SAPHO syndrome. Orphanet Encyclopedia. http://www.orpha.net/data/patho/GB/uk-sapho.pdf. Accessed 17 Feb 2009

11.

Schilling F, Kessler S (2000) The SAPHO syndrome—clinical and radiological differentiation and classification on the basis of 86 cases. Rheumatology 59:1–28. doi:10.1007/s003930050001 CrossRef

12.

Reith JD, Bauer TW, Schils JP (1996) Osseous manifestations of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. Am J Surg Pathol 20:1368–1377. doi:10.1097/00000478-199611000-00008 CrossRefPubMed

13.

Kahn MF, Chamot AM (1992) SAPHO syndrome. Rheum Dis Clin North Am 18:225–246PubMed

14.

Schilling F, Wagner AD (2000) Azithromycin: an anti-inflammatory effect in chronic recurrent multifocal osteomyelitis? A preliminary report. Z Rheumatol 59(5):352–353. doi:10.1007/s003930070059 CrossRefPubMed

15.

Amital H, Applbaum YH, Aamar S et al (2004) SAPHO syndrome treated with pamidronate: an open-label study of 10 patients. Rheumatology 43(5):658–661. doi:10.1093/rheumatology/keh149 CrossRefPubMed

Title: SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature
Authors: Keith Siau
Catherine J. Laversuch
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 8/2010
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-1021-5

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2010

Characteristics of Paget’s disease of bone in the city of Recife, Brazil

Permanent renal loss following tumor necrosis factor α antagonists for arthritis

Dermatomyositis and cutaneous metastases from breast cancer: simultaneous development and parallel course

Myocarditis as a form of relapse in two patients with adult Still’s disease

A systematic review and meta-analysis of the efficacy and safety of adalimumab for treating rheumatoid arthritis

Uncommon clinical pattern of FMF: protracted febrile myalgia syndrome

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage