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Open Access 01-06-2011 | Article

Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

Authors: Frank J. Symons, Jason J. Wolff, Laura S. Stone, Tony K. Y. Lim, James W. Bodfish

Published in: Journal of Neurodevelopmental Disorders | Issue 2/2011

Abstract

Salivary levels of biomarkers for the hypothalamic–pituitary–adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i.e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p < 0.01) between the SIB and control group (SIB > control). Within-group analyses showed significant differences (p < 0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB + SMD > SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r = 0.36, p < 0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.

Aliane V, Pérez S, Bohren Y, Deniau JM, Kemel ML. Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies. Brain. 2011;134:110–8.CrossRefPubMed

Barron J, Sandman CA. Relationship of sedative-hypnotic response to self-injurious behavior and stereotypy by mentally retarded clients. Am J Ment Defic. 1983;88:177–86.PubMed

Blew P, Luiselli JK, Thibadeau S. Beneficial effects of clonidine on severe self-injurious behavior in a 9-year-old girl with pervasive developmental disorder. J Child Adolesc Psychopharmacol. 1999;9:285–91.CrossRefPubMed

Bodfish JW, Crawford TW, Powell SB, Parker DE, Golden RN, Lewis MH. Compulsions in adults with mental retardation: prevalence, phenomenology, and comorbidity with stereotypy and self-injury. Am J Ment Retard. 1995;100:183–92.PubMed

Bosch JA, Brand HS, Ligtenberg TJ, Bermond B, Hoogstraten J, Nieuw Amerongen AV. Psychological stress as a determinant of protein levels and salivary-induced aggregation of Streptococcus gordonii in human whole saliva. Psychosom Med. 1996;58:374–82.CrossRefPubMed

Chatterton RT, Vogelsong KM, Lu YC, Ellman AB, Hudgens GA. Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin Physiol. 1996;16:433–48.CrossRefPubMed

Frecska E, Arato M. Opiate sensitivity test in patients with stereotypic movement disorder and trichotillomania. Prog Neuro-psychopharmacol Biol Psychiatry. 2002;26:909–12.CrossRef

Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, et al. beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science. 1977;197:1367–9.CrossRefPubMed

Graybiel AM. Habits, rituals, and the evaluative brain. Annu Rev Neurosci. 2008;31:359–87.CrossRefPubMed

Hellhammer DH, Wust S, Kudielka BM. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology. 2009;34:163–71.CrossRefPubMed

Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, et al. Aggression and stereotypic behavior in males with fragile X syndrome- moderating secondary genes in a “single gene” disorder. J Autism Dev Disord. 2008;38:184–9.CrossRefPubMed

Hollander E, Anagnostou E, Chaplin W, Esposito K, Haznedar MM, Licalzi E, et al. Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biol Psychiatry. 2005;58:226–32.CrossRefPubMed

Kemp AS, Fillmore PT, Lenjavi MR, Lyon M, Chicz-DeMet A, Touchette PE, et al. Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled. Psychiatr Res. 2008;157:181–9.CrossRef

Luchins DJ, Dojka D. Lithium and propranolol in aggression and self-injurious behavior in the mentally retarded. Psychopharmacol Bull. 1989;25:372–5.PubMed

Major CA, Kelly BJ, Novak MA, Davenport MD, Stonemetz KM, Meyer JS. The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). Life Sci. 2009;85:753–8.CrossRefPubMedCentralPubMed

Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: Implications for dopamine-associated psychiatric disorders. Biol Psychiatry. 2002;51:775–87.CrossRefPubMed

Nater UM, Rohleder N. Salivary α-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology. 2009;34:486–96.CrossRefPubMed

Nater UM, Rohleder N, Gaab J, Berger S, Jud A, Kirschbaum C, et al. Human salivary alpha-amylase reactivity in a psychosocial stress paradigm. Int J Psychophysiol. 2005;55:333–42.CrossRefPubMed

Novak MA. Self-injurious behavior in rhesus monkeys: new insights into its etiology, physiology, and treatment. Am J Primatol. 2003;59:3–19.CrossRefPubMed

Osman OT, Loschen EL. Self-injurious behavior in the developmentally disabled: pharmacological treatment. Psychopharmacol Bull. 1992;28:439–49.PubMed

Philipsen A, Richter H, Schmahl C, Peters J, Rusch N, Bohus M, et al. Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder. J Clin Psychiatry. 2004;65:1414–9.CrossRefPubMed

Rohleder N, Nater UM. Determinants of salivary α-amylase in humans and methodological considerations. Psychoneuroendocrinology. 2009;34:469–85.CrossRefPubMed

Rohleder N, Nater UM, Wolf JM, Ehlert U, Kirschbaum C. Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity? Ann NY Acad Sci. 2004;1032:258–63.CrossRefPubMed

Rojahn J. Self-injurious and stereotypic behavior of noninstitutionalized mentally retarded people: prevalence and classification. Am J Ment Defic. 1986;91:268–76.PubMed

Rojahn J, Matson JL, Lott D, Esbensen A, Smalls Y. The Behavior Problems Inventory: An instrument for the assessment of self-injury, stereotyped behavior, and aggression/destruction in individuals with developmental disabilities. J Autism Dev Disord. 2001;31:577–88.CrossRefPubMed

Ruedrich SL, Grush L, Wilson J. Beta adrenergic blocking medications for aggressive or self-injurious mentally retarded persons. Am J Ment Retard. 1990;95:110–9.PubMed

Sachsse U, Von der Heyde S, Huether G. Stress regulation and self-mutilation. Am J Psychiatry. 2002;159:672.CrossRefPubMed

Sandman CA, Barron JL, Chicz-DeMet A, DeMet EM. Plasma B-endorphin levels in patients with self-injurious behavior and stereotypy. Am J Ment Retard. 1990;95:84–92.PubMed

Sandman CA, Hetrick W, Taylor DV, Chicz-DeMet A. Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers. Am J Ment Retard. 1997;102:182–99.CrossRefPubMed

Sandman CA, Spence MA, Smith M. Proopiomelanocortin (POMC) disregulation and response to opiate blockers. Ment Retard Dev Disabil Res Rev. 1999;5:314–21.CrossRef

Sandman CA, Touchette P, Lenjavi M, Marion S, Chicz-DeMet A. beta-Endorphin and ACTH are dissociated after self-injury in adults with developmental disabilities. Am J Ment Retard. 2003;108:414–24.CrossRefPubMed

Schouten WG, Wiegant VM. Individual responses to acute and chronic stress in pigs. Acta Physiol Scand Suppl. 1997;640:88–91.PubMed

Schroeder SR, Oster-Granite ML, Berkson G, Bodfish JW, Breese GR, Cataldo MF, et al. Self-injurious behavior: Gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev. 2001;7:3–12.CrossRefPubMed

Stahl F, Dorner G. Responses of salivary cortisol levels to stress situations. Endokrinologie. 1982;80:158–62.PubMed

Symons FJ, Sutton KA, Walker C, Bodfish JW. Altered diurnal patterns of salivary substance P in adults with developmental disabilities and chronic self-injury. Am J Ment Retard. 2003;108:13–8.CrossRefPubMed

Symons FJ, Thompson A, Realmuto G. Clonidine for self-injurious behavior. J Am Acad Child Adolesc Psychiatry. 2004;43:1324–5.CrossRefPubMed

Tiefenbacher S, Novak MA, Jorgensen MJ, Meyer JS. Physiological correlates of self-injurious behavior in captive, socially-reared rhesus monkeys. Psychoneuroendocrinology. 2000;25:799–817.CrossRefPubMed

van Stegeren A, Rohleder N, Eveaerd W, Wolf OT. Salivary alpha amylase as marker for adrenergic activity during stress: effect of betablockade. Psychoneuroendocrinology. 2006;31:137–41.CrossRefPubMed

Verhoeven WM, Tuinier S, van den Berg YWMM, Coppus AMW, Fekkes D, Pepplinkhuizen L, et al. Stress and self-injurious behavior; hormonal and serotonergic parameters in mentally retarded subjects. Pharmacopsychiatry. 1999;32:13–20.CrossRefPubMed

Wong DF, Harris JC, Naidu S, Yokoi F, Marenco S, Dannals RF, et al. Dopamine transporters are markedly reduced in Lesch-Nyhan disease in-vivo. PNAS. 1996;93:5539–43.CrossRefPubMedCentralPubMed

Title: Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders
Authors: Frank J. Symons
Jason J. Wolff
Laura S. Stone
Tony K. Y. Lim
James W. Bodfish
Publication date: 01-06-2011
Publisher: BioMed Central
Published in: Journal of Neurodevelopmental Disorders / Issue 2/2011
Print ISSN: 1866-1947
Electronic ISSN: 1866-1955
DOI: https://doi.org/10.1007/s11689-011-9080-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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