Skip to main content
Top
Published in: Current Diabetes Reports 10/2016

01-10-2016 | Obesity (J McCaffery, Section Editor)

Salivary Amylase: Digestion and Metabolic Syndrome

Authors: Catherine Peyrot des Gachons, Paul A. S. Breslin

Published in: Current Diabetes Reports | Issue 10/2016

Login to get access

Abstract

Salivary amylase is a glucose-polymer cleavage enzyme that is produced by the salivary glands. It comprises a small portion of the total amylase excreted, which is mostly made by the pancreas. Amylases digest starch into smaller molecules, ultimately yielding maltose, which in turn is cleaved into two glucose molecules by maltase. Starch comprises a significant portion of the typical human diet for most nationalities. Given that salivary amylase is such a small portion of total amylase, it is unclear why it exists and whether it conveys an evolutionary advantage when ingesting starch. This review will consider the impact of salivary amylase on oral perception, nutrient signaling, anticipatory metabolic reflexes, blood sugar, and its clinical implications for preventing metabolic syndrome and obesity.
Literature
1.
go back to reference Dawes C, Pedersen AM, Villa A, et al. The functions of human saliva: a review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol. 2015;60(6):863–74.PubMedCrossRef Dawes C, Pedersen AM, Villa A, et al. The functions of human saliva: a review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol. 2015;60(6):863–74.PubMedCrossRef
2.
go back to reference Ruhl S. The scientific exploration of saliva in the post-proteomic era: from database back to basic function. Expert Rev Proteomics. 2012;9(1):85–96.PubMedPubMedCentralCrossRef Ruhl S. The scientific exploration of saliva in the post-proteomic era: from database back to basic function. Expert Rev Proteomics. 2012;9(1):85–96.PubMedPubMedCentralCrossRef
3.
go back to reference Matsuo R. Role of saliva in the maintenance of taste sensitivity. Crit Rev Oral Biol Med. 2000;11(2):216–29.PubMedCrossRef Matsuo R. Role of saliva in the maintenance of taste sensitivity. Crit Rev Oral Biol Med. 2000;11(2):216–29.PubMedCrossRef
4.
go back to reference Henkin RI, Gill Jr JR, Bartter FC. Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. J Clin Invest. 1963;42(5):727.PubMedPubMedCentralCrossRef Henkin RI, Gill Jr JR, Bartter FC. Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. J Clin Invest. 1963;42(5):727.PubMedPubMedCentralCrossRef
5.
go back to reference Power ML, Schulkin J. Anticipatory physiological regulation in feeding biology: cephalic phase responses. Appetite. 2008;50(2):194–206.PubMedCrossRef Power ML, Schulkin J. Anticipatory physiological regulation in feeding biology: cephalic phase responses. Appetite. 2008;50(2):194–206.PubMedCrossRef
8.
go back to reference Scannapieco FA, Torres G, Levine MJ. Salivary α-amylase: role in dental plaque and caries formation. Crit Rev Oral Biol Med. 1993;4(3):301–7.PubMed Scannapieco FA, Torres G, Levine MJ. Salivary α-amylase: role in dental plaque and caries formation. Crit Rev Oral Biol Med. 1993;4(3):301–7.PubMed
9.
go back to reference Jacobsen N, Melvaer KL, Hensten-Pettersen A. Some properties of salivary amylase: a survey of the literature and some observations. J Dent Res. 1972;51(2):381–8.PubMedCrossRef Jacobsen N, Melvaer KL, Hensten-Pettersen A. Some properties of salivary amylase: a survey of the literature and some observations. J Dent Res. 1972;51(2):381–8.PubMedCrossRef
10.
go back to reference Hall FF, Ratliff CR, Hayakawa T, et al. Substrate differentiation of human pancreatic and salivary alpha-amylases. Am J Dig Dis. 1970;15(11):1031–8.PubMedCrossRef Hall FF, Ratliff CR, Hayakawa T, et al. Substrate differentiation of human pancreatic and salivary alpha-amylases. Am J Dig Dis. 1970;15(11):1031–8.PubMedCrossRef
11.
go back to reference Rosenblum JL, Irwin CL, Alpers DH. Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH. Am J Physiol Gastrointest Liver Physiol. 1988;254(5):G775–80. Rosenblum JL, Irwin CL, Alpers DH. Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH. Am J Physiol Gastrointest Liver Physiol. 1988;254(5):G775–80.
12.
go back to reference Hoebler C, Karinthi A, Devaux MF, et al. Physical and chemical transformations of cereal food during oral digestion in human subjects. Br J Nutr. 1998;80(05):429–36.PubMedCrossRef Hoebler C, Karinthi A, Devaux MF, et al. Physical and chemical transformations of cereal food during oral digestion in human subjects. Br J Nutr. 1998;80(05):429–36.PubMedCrossRef
13.
go back to reference Mandel AL, Peyrot des Gachons C, Plank KL, et al. Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch. PLoS One. 2010;5(10):e13352.PubMedPubMedCentralCrossRef Mandel AL, Peyrot des Gachons C, Plank KL, et al. Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch. PLoS One. 2010;5(10):e13352.PubMedPubMedCentralCrossRef
14.
go back to reference Lapis TJ, Penner MH, Lim J. Evidence that humans can taste glucose polymers. Chem Senses. 2014;39(9):737–47.PubMedCrossRef Lapis TJ, Penner MH, Lim J. Evidence that humans can taste glucose polymers. Chem Senses. 2014;39(9):737–47.PubMedCrossRef
15.
go back to reference Boehlke C, Zierau O, Hannig C. Salivary amylase—the enzyme of unspecialized euryphagous animals. Arch Oral Biol. 2015;60(8):1162–76.PubMedCrossRef Boehlke C, Zierau O, Hannig C. Salivary amylase—the enzyme of unspecialized euryphagous animals. Arch Oral Biol. 2015;60(8):1162–76.PubMedCrossRef
16.
go back to reference Samuelson LC, Phillips RS, Swanberg LJ. Amylase gene structures in primates: retroposon insertions and promoter evolution. Mol Biol Evol. 1996;13(6):767–79.PubMedCrossRef Samuelson LC, Phillips RS, Swanberg LJ. Amylase gene structures in primates: retroposon insertions and promoter evolution. Mol Biol Evol. 1996;13(6):767–79.PubMedCrossRef
17.
go back to reference Chatterton RT, Vogelsong KM, Lu Y, Ellman AB, Hudgens GA. Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin Physiol. 1996;16:433–48.PubMedCrossRef Chatterton RT, Vogelsong KM, Lu Y, Ellman AB, Hudgens GA. Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin Physiol. 1996;16:433–48.PubMedCrossRef
18.
go back to reference Ehlert U, Kirschbaum C. Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology. 2007;32(4):392–401.PubMedCrossRef Ehlert U, Kirschbaum C. Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology. 2007;32(4):392–401.PubMedCrossRef
20.
go back to reference Bank RA, Hettema EH, Muijs MA, et al. Variation in gene copy number and polymorphism of the human salivary amylase isoenzyme system in Caucasians. Hum Genet. 1992;89(2):213–22.PubMedCrossRef Bank RA, Hettema EH, Muijs MA, et al. Variation in gene copy number and polymorphism of the human salivary amylase isoenzyme system in Caucasians. Hum Genet. 1992;89(2):213–22.PubMedCrossRef
22.
go back to reference Yang ZM, Lin J, Chen LH, et al. The roles of AMY1 copies and protein expression in human salivary α-amylase activity. Physiol Behav. 2015;138:173–8.PubMedCrossRef Yang ZM, Lin J, Chen LH, et al. The roles of AMY1 copies and protein expression in human salivary α-amylase activity. Physiol Behav. 2015;138:173–8.PubMedCrossRef
23.
go back to reference Groot PC, Mager WH, Henriquez NV, et al. Evolution of the human α-amylase multigene family through unequal, homologous, and inter-and intrachromosomal crossovers. Genomics. 1990;8(1):97–105.PubMedCrossRef Groot PC, Mager WH, Henriquez NV, et al. Evolution of the human α-amylase multigene family through unequal, homologous, and inter-and intrachromosomal crossovers. Genomics. 1990;8(1):97–105.PubMedCrossRef
24.
go back to reference Cooper GM, Nickerson DA, Eichler EE. Mutational and selective effects on copy-number variants in the human genome. Nat Genet. 2007;39:S22–9.PubMedCrossRef Cooper GM, Nickerson DA, Eichler EE. Mutational and selective effects on copy-number variants in the human genome. Nat Genet. 2007;39:S22–9.PubMedCrossRef
25.
go back to reference Perry GH. The evolutionary significance of copy number variation in the human genome. Cytogenet Genome Res. 2008;123(1–4):283–7.PubMed Perry GH. The evolutionary significance of copy number variation in the human genome. Cytogenet Genome Res. 2008;123(1–4):283–7.PubMed
26.
go back to reference Carpenter D, Dhar S, Mitchell LM, et al. Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes. Hum Mol Genet. 2015;24(12):3472–80.PubMedPubMedCentralCrossRef Carpenter D, Dhar S, Mitchell LM, et al. Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes. Hum Mol Genet. 2015;24(12):3472–80.PubMedPubMedCentralCrossRef
27.
go back to reference Usher CL, Handsaker RE, Esko T, et al. Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Nat Genet. 2015;47(8):921–5.PubMedPubMedCentralCrossRef Usher CL, Handsaker RE, Esko T, et al. Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Nat Genet. 2015;47(8):921–5.PubMedPubMedCentralCrossRef
28.
go back to reference Hardy K, Brand-Miller J, Brown KD, et al. The importance of dietary carbohydrate in human evolution. Q Rev Biol. 2015;90(3):251–68.PubMedCrossRef Hardy K, Brand-Miller J, Brown KD, et al. The importance of dietary carbohydrate in human evolution. Q Rev Biol. 2015;90(3):251–68.PubMedCrossRef
29.
go back to reference Simpson JW, Doxey DL, Brown R. Serum isoamylase values in normal dogs and dogs with exocrine pancreatic insufficiency. Vet Res Commun. 1984;8(1):303–8.PubMedCrossRef Simpson JW, Doxey DL, Brown R. Serum isoamylase values in normal dogs and dogs with exocrine pancreatic insufficiency. Vet Res Commun. 1984;8(1):303–8.PubMedCrossRef
30.••
go back to reference Axelsson E, Ratnakumar A, Arendt ML, et al. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature. 2013;495(7441):360–4. Show evidence for gain-of-function in AMY2B gene but also in the MGAM and SGLT1 genes in dogs.PubMedCrossRef Axelsson E, Ratnakumar A, Arendt ML, et al. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature. 2013;495(7441):360–4. Show evidence for gain-of-function in AMY2B gene but also in the MGAM and SGLT1 genes in dogs.PubMedCrossRef
31.
go back to reference Arendt M, Fall T, Lindblad‐Toh K, et al. Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes. Anim Genet. 2014;45(5):716–22.PubMedPubMedCentralCrossRef Arendt M, Fall T, Lindblad‐Toh K, et al. Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes. Anim Genet. 2014;45(5):716–22.PubMedPubMedCentralCrossRef
32.
go back to reference Ting CN, Rosenberg MP, Snow CM, Samuelson LC, Meisler MH. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev. 1992;6:1457–65.PubMedCrossRef Ting CN, Rosenberg MP, Snow CM, Samuelson LC, Meisler MH. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev. 1992;6:1457–65.PubMedCrossRef
33.
go back to reference Meisler MH, Ting CN. The remarkable evolutionary history of the human amylase genes. Crit Rev Oral Biol Med. 1993;4(3):503–9.PubMed Meisler MH, Ting CN. The remarkable evolutionary history of the human amylase genes. Crit Rev Oral Biol Med. 1993;4(3):503–9.PubMed
34.
go back to reference Evans ID, Haisman DR, Elson EL, et al. The effect of salivary amylase on the viscosity behaviour of gelatinised starch suspensions and the mechanical properties of gelatinised starch granules. J Sci Food Agric. 1986;37(6):573–90.CrossRef Evans ID, Haisman DR, Elson EL, et al. The effect of salivary amylase on the viscosity behaviour of gelatinised starch suspensions and the mechanical properties of gelatinised starch granules. J Sci Food Agric. 1986;37(6):573–90.CrossRef
35.
go back to reference Sclafani A, Nissenbaum JW, Vigorito M. Starch preference in rats. Neurosci Biobehav Rev. 1987;11(2):253–62.PubMedCrossRef Sclafani A, Nissenbaum JW, Vigorito M. Starch preference in rats. Neurosci Biobehav Rev. 1987;11(2):253–62.PubMedCrossRef
36.
go back to reference Vigorito M, Sclafani A. Ontogeny of polycose and sucrose appetite in neonatal rats. Dev Psychobiol. 1988;21(5):457–65.PubMedCrossRef Vigorito M, Sclafani A. Ontogeny of polycose and sucrose appetite in neonatal rats. Dev Psychobiol. 1988;21(5):457–65.PubMedCrossRef
37.
go back to reference Ramirez IS. Chemoreception for an insoluble nonvolatile substance: starch taste? Am J Physiol Regul Integr Comp Physiol. 1991;260(1):R192–9. Ramirez IS. Chemoreception for an insoluble nonvolatile substance: starch taste? Am J Physiol Regul Integr Comp Physiol. 1991;260(1):R192–9.
38.
go back to reference Treesukosol Y, Smith KR, Spector AC. Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+ 3 heterodimer in a mouse model. J Neurosci Nurs. 2011;31(38):13527–34.CrossRef Treesukosol Y, Smith KR, Spector AC. Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+ 3 heterodimer in a mouse model. J Neurosci Nurs. 2011;31(38):13527–34.CrossRef
39.
go back to reference Zukerman S, Glendinning JI, Margolskee RF, et al. T1R3 taste receptor is critical for sucrose but not polycose taste. Am J Physiol Regul Integr Comp Physiol. 2009;296(4):R866–76.PubMedCrossRef Zukerman S, Glendinning JI, Margolskee RF, et al. T1R3 taste receptor is critical for sucrose but not polycose taste. Am J Physiol Regul Integr Comp Physiol. 2009;296(4):R866–76.PubMedCrossRef
40.
go back to reference Breslin PAS, Beauchamp GK, Pugh EN. Monogeusia for fructose, glucose, sucrose, and maltose. Percept Psychophys. 1996;58(3):327–41.PubMedCrossRef Breslin PAS, Beauchamp GK, Pugh EN. Monogeusia for fructose, glucose, sucrose, and maltose. Percept Psychophys. 1996;58(3):327–41.PubMedCrossRef
41.
go back to reference Yee KK, Sukumaran SK, Kotha R, et al. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci. 2011;108(13):5431–6.PubMedPubMedCentralCrossRef Yee KK, Sukumaran SK, Kotha R, et al. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci. 2011;108(13):5431–6.PubMedPubMedCentralCrossRef
42.••
go back to reference Sukumaran SK, Yee KK, Iwata S, et al. Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. PNAS. 2016;113(21):6035–40. Evidence of the expression of salivary amylase and maltase in taste cells and surrounding lingual salivary glands.PubMedCrossRef Sukumaran SK, Yee KK, Iwata S, et al. Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. PNAS. 2016;113(21):6035–40. Evidence of the expression of salivary amylase and maltase in taste cells and surrounding lingual salivary glands.PubMedCrossRef
43.
go back to reference Margolskee RF, Dyer J, Kokrashvili Z, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na + −glucose cotransporter 1. Proc Natl Acad Sci. 2007;104(38):15075–80.PubMedPubMedCentralCrossRef Margolskee RF, Dyer J, Kokrashvili Z, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na + −glucose cotransporter 1. Proc Natl Acad Sci. 2007;104(38):15075–80.PubMedPubMedCentralCrossRef
44.
go back to reference Cloutier M, Gingras D, Bendayan M. Internalization and transcytosis of pancreatic enzymes by the intestinal mucosa. J Histochem Cytochem. 2006;54(7):781–94.PubMedCrossRef Cloutier M, Gingras D, Bendayan M. Internalization and transcytosis of pancreatic enzymes by the intestinal mucosa. J Histochem Cytochem. 2006;54(7):781–94.PubMedCrossRef
45.
go back to reference Merigo F, Benati D, Cecchini MP, et al. Amylase expression in taste receptor cells of rat circumvallate papillae. Cell Tissue Res. 2009;336(3):411–21.PubMedCrossRef Merigo F, Benati D, Cecchini MP, et al. Amylase expression in taste receptor cells of rat circumvallate papillae. Cell Tissue Res. 2009;336(3):411–21.PubMedCrossRef
46.
go back to reference Pavlov IP. The work of the digestive glands. London: Charles Griffin Co Ltd; 1902. Pavlov IP. The work of the digestive glands. London: Charles Griffin Co Ltd; 1902.
47.
go back to reference Farrell JI. Contributions to the physiology of gastric secretion. Am J Physiol. 1928;85:672–87. Farrell JI. Contributions to the physiology of gastric secretion. Am J Physiol. 1928;85:672–87.
48.
go back to reference Preshaw RM, Cooke AR, Grossman MI. Quantitative aspects of response of canine pancreas to duodenal acidification. Gastroenterology. 1966;210:629–34. Preshaw RM, Cooke AR, Grossman MI. Quantitative aspects of response of canine pancreas to duodenal acidification. Gastroenterology. 1966;210:629–34.
49.
go back to reference Powley TL. The ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis. Psychol Rev. 1977;84:89–126.PubMedCrossRef Powley TL. The ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis. Psychol Rev. 1977;84:89–126.PubMedCrossRef
50.
go back to reference Ahren B, Holst JJ. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. 2001;50:1030–8.PubMedCrossRef Ahren B, Holst JJ. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. 2001;50:1030–8.PubMedCrossRef
51.
go back to reference Mandel AL, Breslin PA. High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults. J Nutr. 2012;142(5):853–8.PubMedPubMedCentralCrossRef Mandel AL, Breslin PA. High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults. J Nutr. 2012;142(5):853–8.PubMedPubMedCentralCrossRef
52.
go back to reference Glendinning JI, Stano S, Holter M, et al. Sugar-induced cephalic-phase insulin release is mediated by a T1r2+ T1r3-independent taste transduction pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2015;309(5):R552–60.PubMedPubMedCentralCrossRef Glendinning JI, Stano S, Holter M, et al. Sugar-induced cephalic-phase insulin release is mediated by a T1r2+ T1r3-independent taste transduction pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2015;309(5):R552–60.PubMedPubMedCentralCrossRef
53.
54.
go back to reference Schneyer CA, Schneyer LH. Amylase in rat serum, submaxillary gland and liver following pilocarpine administration or normal feeding. Am J Physiol. 1960;198:771–3.PubMed Schneyer CA, Schneyer LH. Amylase in rat serum, submaxillary gland and liver following pilocarpine administration or normal feeding. Am J Physiol. 1960;198:771–3.PubMed
55.
go back to reference Schrifin A, Tuchman L, Antopol W. Blood amylase response to acetyl-b-methylcholine chloride in rabbits. Proc Soc Exp Biol Med. 1936;34:539–40.CrossRef Schrifin A, Tuchman L, Antopol W. Blood amylase response to acetyl-b-methylcholine chloride in rabbits. Proc Soc Exp Biol Med. 1936;34:539–40.CrossRef
56.
go back to reference Isenman L, Liebow C, Rothman S. The endocrine secretion of mammalian digestive enzymes by exocrine glands. Am J Physiol Endocrinol Metab. 1999;276(2):E223–32. Isenman L, Liebow C, Rothman S. The endocrine secretion of mammalian digestive enzymes by exocrine glands. Am J Physiol Endocrinol Metab. 1999;276(2):E223–32.
57.
go back to reference Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am. 1990;19(4):793–810.PubMed Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am. 1990;19(4):793–810.PubMed
58.
go back to reference Proctor GB, Asking B, Garrett JR. Serum amylase of non-parotid and non-pancreatic origin increases on feeding in rats and may originate from the liver. Comp Biochem Physiol B Biochem Mol Biol. 1991;98(4):631–5.CrossRef Proctor GB, Asking B, Garrett JR. Serum amylase of non-parotid and non-pancreatic origin increases on feeding in rats and may originate from the liver. Comp Biochem Physiol B Biochem Mol Biol. 1991;98(4):631–5.CrossRef
59.
60.
go back to reference Hokari S, Miura K, Koyama I, et al. Expression of α-amylase isozymes in rat tissues. Comp Biochem Physiol B Biochem Mol Biol. 2003;135(1):63–9.PubMedCrossRef Hokari S, Miura K, Koyama I, et al. Expression of α-amylase isozymes in rat tissues. Comp Biochem Physiol B Biochem Mol Biol. 2003;135(1):63–9.PubMedCrossRef
61.
go back to reference McGeachin RL, Abshier WM, O’Leary K. The effects of puromycin and actinomycin D on the serum and liver amylase levels in the mouse, rabbit, and rat. Carbohydr Res. 1978;61(1):425–9.PubMedCrossRef McGeachin RL, Abshier WM, O’Leary K. The effects of puromycin and actinomycin D on the serum and liver amylase levels in the mouse, rabbit, and rat. Carbohydr Res. 1978;61(1):425–9.PubMedCrossRef
62.
go back to reference Rohr G, Scheele G. Fate of radioactive exocrine pancreatic proteins injected into the blood circulation of the rat. Tissue uptake and transepithelial excretion. Gastroenterol. 1983;85(5):991–1002. Rohr G, Scheele G. Fate of radioactive exocrine pancreatic proteins injected into the blood circulation of the rat. Tissue uptake and transepithelial excretion. Gastroenterol. 1983;85(5):991–1002.
63.••
go back to reference Falchi M, Moustafa JS, Takousis P, et al. Low copy number of the salivary amylase gene predisposes to obesity. Nat Genet. 2014;46(5):492–7. First article showing a positive association between AMY CN and obesity.PubMedCrossRef Falchi M, Moustafa JS, Takousis P, et al. Low copy number of the salivary amylase gene predisposes to obesity. Nat Genet. 2014;46(5):492–7. First article showing a positive association between AMY CN and obesity.PubMedCrossRef
64.
go back to reference Viljakainen H, Andersson-Assarsson JC, Armenio M, et al. Low copy number of the AMY1 locus is associated with early-onset female obesity in Finland. PLoS One. 2015;10(7):e0131883.PubMedPubMedCentralCrossRef Viljakainen H, Andersson-Assarsson JC, Armenio M, et al. Low copy number of the AMY1 locus is associated with early-onset female obesity in Finland. PLoS One. 2015;10(7):e0131883.PubMedPubMedCentralCrossRef
65.
go back to reference Mejía-Benítez MA, Bonnefond A, Yengo L, et al. Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia. 2015;58(2):290–4.PubMedCrossRef Mejía-Benítez MA, Bonnefond A, Yengo L, et al. Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia. 2015;58(2):290–4.PubMedCrossRef
66.
go back to reference Marcovecchio ML, Florio R, Verginelli F, et al. Low AMY1 gene copy number is associated with increased body mass index in prepubertal boys. PLoS One. 2016;11(5):e0154961.PubMedPubMedCentralCrossRef Marcovecchio ML, Florio R, Verginelli F, et al. Low AMY1 gene copy number is associated with increased body mass index in prepubertal boys. PLoS One. 2016;11(5):e0154961.PubMedPubMedCentralCrossRef
67.
go back to reference Usher CL, McCarroll SA. Complex and multi-allelic copy number variation in human disease. Brief Funct Genomics. 2015;elv028.14:329–38. Usher CL, McCarroll SA. Complex and multi-allelic copy number variation in human disease. Brief Funct Genomics. 2015;elv028.14:329–38.
68.
go back to reference Yong RY, Mustaffa SA, Wasan PS, et al. Complex copy number variation of AMY1 does not associate with obesity in two East Asian cohorts. Hum Mutat. 2016;37:669–78. Yong RY, Mustaffa SA, Wasan PS, et al. Complex copy number variation of AMY1 does not associate with obesity in two East Asian cohorts. Hum Mutat. 2016;37:669–78.
69.••
go back to reference Nakajima K. Low serum amylase and obesity, diabetes and metabolic syndrome: a novel interpretation. World J Diabetes. 2016;7(6):112. Interesting review on low serum amylase and metabolic syndrome.PubMedPubMedCentralCrossRef Nakajima K. Low serum amylase and obesity, diabetes and metabolic syndrome: a novel interpretation. World J Diabetes. 2016;7(6):112. Interesting review on low serum amylase and metabolic syndrome.PubMedPubMedCentralCrossRef
70.
go back to reference Skrha J, Stĕpán J. Clinical significance of amylase isoenzyme determination. Acta Univ Carol Med Monogr. 1986;120:1–81. Skrha J, Stĕpán J. Clinical significance of amylase isoenzyme determination. Acta Univ Carol Med Monogr. 1986;120:1–81.
71.
go back to reference Dandona P, Freedman DB, Foo Y, Perkins J, Katrak A, Mikhailidis DP, et al. Exocrine pancreatic function in diabetes mellitus. J Clin Pathol. 1984;37:302–6.PubMedPubMedCentralCrossRef Dandona P, Freedman DB, Foo Y, Perkins J, Katrak A, Mikhailidis DP, et al. Exocrine pancreatic function in diabetes mellitus. J Clin Pathol. 1984;37:302–6.PubMedPubMedCentralCrossRef
72.
go back to reference Swislocki A, Noth R, Hallstone A, Kyger E, Triadafilopoulos G. Secretin-stimulated amylase release into blood is impaired in type 1 diabetes mellitus. Horm Metab Res. 2005;37:326–30.PubMedCrossRef Swislocki A, Noth R, Hallstone A, Kyger E, Triadafilopoulos G. Secretin-stimulated amylase release into blood is impaired in type 1 diabetes mellitus. Horm Metab Res. 2005;37:326–30.PubMedCrossRef
73.
go back to reference Lee JG, Park SW, Cho BM, et al. Serum amylase and risk of the metabolic syndrome in Korean adults. Clin Chim Acta. 2011;412(19):1848–53.PubMedCrossRef Lee JG, Park SW, Cho BM, et al. Serum amylase and risk of the metabolic syndrome in Korean adults. Clin Chim Acta. 2011;412(19):1848–53.PubMedCrossRef
74.
go back to reference Nakajima K, Nemoto T, Muneyuki T, et al. Low serum amylase in association with metabolic syndrome and diabetes: a community-based study. Cardiovasc Diabetol. 2011;10(1):34.PubMedPubMedCentralCrossRef Nakajima K, Nemoto T, Muneyuki T, et al. Low serum amylase in association with metabolic syndrome and diabetes: a community-based study. Cardiovasc Diabetol. 2011;10(1):34.PubMedPubMedCentralCrossRef
76.
go back to reference Muneyuki T, Nakajima K, Aoki A, et al. Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults. Cardiovasc Diabetol. 2012;11(80):10–186. Muneyuki T, Nakajima K, Aoki A, et al. Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults. Cardiovasc Diabetol. 2012;11(80):10–186.
77.
go back to reference Zhao Y, Zhang J, Zhang J, et al. Metabolic syndrome and diabetes are associated with low serum amylase in a Chinese asymptomatic population. Scand J Clin Lab Invest. 2014;74(3):235–9.PubMedCrossRef Zhao Y, Zhang J, Zhang J, et al. Metabolic syndrome and diabetes are associated with low serum amylase in a Chinese asymptomatic population. Scand J Clin Lab Invest. 2014;74(3):235–9.PubMedCrossRef
78.
go back to reference Mossner J, Logsdon CD, Goldfine ID, et al. Regulation of pancreatic acinar cell insulin receptors by insulin. Am J Physiol Gastrointest Liver Physiol. 1984;247(2):G155–60. Mossner J, Logsdon CD, Goldfine ID, et al. Regulation of pancreatic acinar cell insulin receptors by insulin. Am J Physiol Gastrointest Liver Physiol. 1984;247(2):G155–60.
79.
go back to reference Schneeman BO, Inman MD, Stern JS. Pancreatic enzyme activity in obese and lean Zucker rats: a developmental study. J Nutr. 1983;113(4):921–5.PubMed Schneeman BO, Inman MD, Stern JS. Pancreatic enzyme activity in obese and lean Zucker rats: a developmental study. J Nutr. 1983;113(4):921–5.PubMed
80.
go back to reference Carter DA, Wobken JD, Dixit PK, et al. Immunoreactive insulin in rat salivary glands and its dependence on age and serum insulin levels. Exp Biol Med. 1995;209(3):245–50.CrossRef Carter DA, Wobken JD, Dixit PK, et al. Immunoreactive insulin in rat salivary glands and its dependence on age and serum insulin levels. Exp Biol Med. 1995;209(3):245–50.CrossRef
81.
go back to reference Rocha EM, Carvalho CR, Saad MJ, et al. The influence of ageing on the insulin signalling system in rat lacrimal and salivary glands. Acta Ophthalmol Scand. 2003;81(6):639–45.PubMedCrossRef Rocha EM, Carvalho CR, Saad MJ, et al. The influence of ageing on the insulin signalling system in rat lacrimal and salivary glands. Acta Ophthalmol Scand. 2003;81(6):639–45.PubMedCrossRef
Metadata
Title
Salivary Amylase: Digestion and Metabolic Syndrome
Authors
Catherine Peyrot des Gachons
Paul A. S. Breslin
Publication date
01-10-2016
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 10/2016
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-016-0794-7

Other articles of this Issue 10/2016

Current Diabetes Reports 10/2016 Go to the issue

Health Care Delivery Systems and Implementation in Diabetes (EB Morton-Eggleston and ME McDonnell, Section Editors)

Taking Telemedicine to the Next Level in Diabetes Population Management: a Review of the Endo ECHO Model

Pharmacologic Treatment of Type 2 Diabetes (HE Lebovitz and G Bahtiyar, Section Editors)

What Are We Learning from the FDA-Mandated Cardiovascular Outcome Studies for New Pharmacological Antidiabetic Agents?

Microvascular Complications—Retinopathy (JK Sun and PS Silva, Section Editors)

Fenofibrate and Diabetic Retinopathy

Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (C Shay and B Conway, Section Editors)

Viral Hepatitis and Diabetes: Clinical Implications of Diabetes Prevention Through Hepatitis Vaccination

Pharmacologic Treatment of Type 2 Diabetes (HE Lebovitz and G Bahtiyar, Section Editors)

SGLT2 Inhibitors: Benefit/Risk Balance

Treatment of Type 1 Diabetes (M Pietropaolo, Section Editor)

Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.