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Indian Journal of Gastroenterology
Published in: Indian Journal of Gastroenterology 6/2010

01-11-2010 | Letter

Safety profile of six months lansoprozole treatment in children

Authors: Makbule Eren, Selda Hekim Yıldırım, Ilknur Ak Sivrikoz

Published in: Indian Journal of Gastroenterology | Issue 6/2010

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Excerpt

Proton pump inhibitors (PPIs) block acid production through H/K ATPase inhibition which is the final pump in the acid secretion pathway. They are generally well tolerated in the short term both in adults and children. However, prolonged suppression of acid secretion may interfere with absorption of various minerals, vitamins, and hematinic factors [1]. Although parietal cells are the major site for PPI activation, H/K ATPase pumps which are found in leukocytes and osteoclasts may also be a target for PPIs, which may therefore have some other deleterious effects beside gastric acid inhibition. …
Literature
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Tolia V, Boyer K. Long term proton pump inhibitor use in children: A retrospective review of safety. Dig Dis Sci. 2008;53:385–93.CrossRefPubMed
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McColl KE. Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol. 2009;104:5–9.CrossRef
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Sharma VR, Brannon MA, Carloss EA. Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia. South Med J. 2004;97:887–9.CrossRefPubMed
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Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol. 2000;30:29–33.CrossRefPubMed
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Insogna KL. The effect of proton pump-inhibiting drugs on mineral metabolism. Am J Gastroenterol. 2009;104:2–4.CrossRef
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Schinke T, Schilling AF, Baranowsky A, et al. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med. 2009;15:674–81.CrossRefPubMed
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Kocsis I, Arató A, Bodánszky H, et al. Short-term omeprazole treatment does not influence biochemical parameters of bone turnover in children. Calcif Tissue Int. 2002;71:129–32.CrossRefPubMed
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Yang YX, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–53.CrossRefPubMed
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Gulmez SE, Holm A, Frederiksen H, et al. Use of proton pump inhibitors and the risk of community-acquired pneumonia: A population-based case-control study. Arch Intern Med. 2007;167:950–5.CrossRefPubMed
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Canani RB, Cirillo P, Roggero P, et al. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics 2006;117:817–20.CrossRef
Metadata
Title
Safety profile of six months lansoprozole treatment in children
Authors
Makbule Eren
Selda Hekim Yıldırım
Ilknur Ak Sivrikoz
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
Indian Journal of Gastroenterology / Issue 6/2010
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-010-0077-1

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