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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 1/2018

01-01-2018 | Original Article

Safety of shortened infusion times for combined ipilimumab and nivolumab

Authors: Maximilian Gassenmaier, Hans-Peter Lipp, Alexander Scheu, Nikolaus Benjamin Wagner, Lukas Kofler, Alisa Mueller, Dennis Doecker, Thomas Kurt Eigentler, Claus Garbe, Andrea Forschner

Published in: Cancer Immunology, Immunotherapy | Issue 1/2018

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Abstract

Background

Combined ipilimumab and nivolumab induces encouraging response rates in patients with unresectable or metastatic melanoma. However, the approved protocol for dual checkpoint inhibition (3 mg/kg ipilimumab over 90 min and 1 mg/kg nivolumab over 60 min) is time-intensive and several trials have shown that both single agents can be safely administered at faster infusion rates.

Aim

To investigate whether combined checkpoint inhibition with 3 mg/kg ipilimumab and 1 mg/kg nivolumab can be safely administered over 30 min per agent.

Patients and methods

We reviewed the rate of infusion-related reactions (IRRs) in the first 12 months of our single-institution experience using shortened infusion times for combined checkpoint inhibition with ipilimumab and nivolumab.

Results

Between May 24, 2016 and June 10, 2017, a total of 46 melanoma patients received 100 shortened cycles of combined 3 mg/kg ipilimumab and 1 mg/kg nivolumab. One patient (2.2%; 1/46) had a questionable reaction after administration of 1 mg/kg nivolumab over 30 min, but none of the other patients had a bona fide IRR.

Conclusions

Shortened infusion times for combined ipilimumab and nivolumab treatment are safe, thereby facilitating a more efficient use of outpatient facilities and enhancing patient’s convenience.
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Metadata
Title
Safety of shortened infusion times for combined ipilimumab and nivolumab
Authors
Maximilian Gassenmaier
Hans-Peter Lipp
Alexander Scheu
Nikolaus Benjamin Wagner
Lukas Kofler
Alisa Mueller
Dennis Doecker
Thomas Kurt Eigentler
Claus Garbe
Andrea Forschner
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Cancer Immunology, Immunotherapy / Issue 1/2018
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-017-2075-y

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