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01-12-2015

Safety and feasibility of simultaneous endoscopic submucosal dissection for multiple gastric neoplasias

Authors: Dong Hoo Joh, Chan Hyuk Park, Sungmo Jung, Seung-Ho Choi, Hyun Ki Kim, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee

Published in: Surgical Endoscopy | Issue 12/2015

Abstract

Background

Synchronous gastric neoplasms are not infrequently detected, thus endoscopic submucosal dissection (ESD) for multiple early gastric neoplasia is occasionally considered. However, there have been few investigations of the safety and feasibility of simultaneous ESD for multiple gastric lesions. This study aims to evaluate the safety and feasibility of simultaneous ESD for multiple gastric neoplasia.

Methods

A total of 1823 patients who underwent ESD for 1929 gastric adenomas or early gastric cancers were retrospectively reviewed in this study. Two hundred gastric adenomas or early gastric cancers among 94 patients were treated by ESD simultaneously (multiple group), and 1729 patients were treated with ESD for a single lesion (single group).

Results

En bloc resection (P = 0.060), complete resection (P = 0.362) and curative resection (P = 0.108) rates did not differ between the two groups. Rates of adverse events including bleeding (P = 0.317), perforation (P = 0.316) and aspiration pneumonia (P = 0.563) were not higher in the multiple group. Long-term follow-up showed more frequent local recurrence (P < 0.001), synchronous neoplasia (P = 0.041) and metachronous neoplasia (P < 0.001) per patient in the multiple group; however, local recurrence per lesion did not differ between the two groups (P = 0.103).

Conclusions

Simultaneous ESD for multiple synchronous gastric neoplasms is safe and feasible compared to single ESD. However, thorough examination for local recurrence and synchronous and metachronous neoplasia is required.

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Title: Safety and feasibility of simultaneous endoscopic submucosal dissection for multiple gastric neoplasias
Authors: Dong Hoo Joh
Chan Hyuk Park
Sungmo Jung
Seung-Ho Choi
Hyun Ki Kim
Hyuk Lee
Jun Chul Park
Sung Kwan Shin
Yong Chan Lee
Sang Kil Lee
Publication date: 01-12-2015
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 12/2015
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-015-4139-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Safety and feasibility of simultaneous endoscopic submucosal dissection for multiple gastric neoplasias

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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