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European Journal of Clinical Microbiology & Infectious Diseases

22-04-2024 | Rubella | Letter to the Editor

Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman

Authors: Vega-López TL, Carballido-Vázquez AM, González-Jiménez I, García-Gamero MJ, Delgado-Mucientes CM, González-López A, Martínez-García G, Rojo-Rello S, Manchado-López P, Mateos-Mayo A

Published in: European Journal of Clinical Microbiology & Infectious Diseases

Excerpt

Cutaneous granulomatous diseases encompass the clinical spectrum of type-IV hypersensitivity reactions, leading to granuloma formation. Histologically, granulomas represent a chronic inflammatory response characterized by focal aggregates of epithelioid histiocytes, multinucleated giant cells, and mononuclear leukocytes. Although their etiology frequently remains unclear, granulomas normally develop in response to chronic infection [1]. Interestingly, the term “rubella virus (RuV) granulomas” has recently been introduced to describe granulomas in which vaccine-derived or wild-type RuV (wt-RuV) has been identified in tissue biopsy [2]. …

Zhang D, Wanat KA, Perelygina L et al (2023) Cutaneous granulomas associated with rubella virus: A clinical review [published online ahead of print, 2023 Jun 2]. J Am Acad Dermatol. ; S0190-9622(23)00998-2. https://doi.org/10.1016/j.jaad.2023.05.058

Wanat KA, Perelygina L, Chen M-h et al (2022) Association of persistent rubella virus with idiopathic skin granulomas in clinically immunocompetent adults. JAMA Dermatol 158(6):626–633. https://doi.org/10.1001/jamadermatol.2022.0828CrossRefPubMedPubMedCentral

Perelygina L, Faisthalab R (2021) AbernathyE,etal. Rubella virus infected macrophages and neutrophils define patterns of granulomatous inflammation in inborn and acquired errors of immunity. Front Immunol 12(5452):796065. https://doi.org/10.3389/fimmu.2021.796065CrossRefPubMedPubMedCentral

Shields BE, Perelygina L, Samimi S et al (2021) Granulomatous Dermatitis Associated with Rubella Virus infection in an adult with immunodeficiency. JAMA Dermatol 157(7):842–847. https://doi.org/10.1001/jamadermatol.2021.1577CrossRefPubMed

Perelygina L, Chen MH, Suppiah S et al (2019) Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies. PLoS Pathog 15(10):e1008080 Published 2019 Oct 28. https://doi.org/10.1371/journal.ppat.1008080CrossRefPubMedPubMedCentral

Perelygina L, Buchbinder D, Dorsey MJ et al (2019) Outcomes for Nitazoxanide Treatment in a Case Series of patients with primary immunodeficiencies and Rubella Virus-Associated Granuloma. J Clin Immunol 39(1):112–117. https://doi.org/10.1007/s10875-019-0589-0CrossRefPubMedPubMedCentral

Title: Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman
Authors: Vega-López TL
Carballido-Vázquez AM
González-Jiménez I
García-Gamero MJ
Delgado-Mucientes CM
González-López A
Martínez-García G
Rojo-Rello S
Manchado-López P
Mateos-Mayo A
Publication date: 22-04-2024
Publisher: Springer Berlin Heidelberg
Keyword: Rubella
Published in: European Journal of Clinical Microbiology & Infectious Diseases
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-024-04828-5

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