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Obesity Surgery
Published in: Obesity Surgery 11/2014

01-11-2014 | Original Contributions

Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats

Authors: Florian Seyfried, Marco Bueter, Kerstin Spliethoff, Alexander D. Miras, Kathrin Abegg, Thomas A. Lutz, Carel W. le Roux

Published in: Obesity Surgery | Issue 11/2014

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Abstract

Background

Whilst weight loss results in many beneficial metabolic consequences, the immediate improvement in glycaemia after Roux-en-Y Gastric bypass (RYGB) remains intriguing. Duodenal jejunal bypass (DJB) induces similar glycaemic effects, while not affecting calorie intake or weight loss. We studied diabetic ZDFfa/fa rats to compare the effects of DJB and RYGB operations on glycaemia.

Methods

Male ZDFfa/fa rats, aged 12 weeks underwent RYGB, DJB or sham operations. Unoperated ZDFfa/fa and ZDFfa/+were used as controls. Body weight, food intake, fasting glucose, insulin and gut hormones were measured at baseline and on postoperative days 2, 10 and 35. An oral glucose tolerance test (OGTT) was performed on days 12 and 26.

Results

DJB had similar food intake and body weight to sham-operated and unoperated control ZDFfa/fa rats (p = NS), but had lower fasting glucose (p < 0.05). RYGB had lower food intake, body weight and fasting glucose compared to all groups (p < 0.001). DJB prevented the progressive decline in fasting insulin observed in the sham-operated or unoperated ZDFfa/fa rats, while RYGB with normalized glycaemia reduced the physiological requirement for raised fasting insulin.

Conclusions

Bypassing the proximal small bowel with the DJB has mild to moderate body weight independent effects on glucose homeostasis and preservation of fasting insulin levels in the medium term. These effects might be further amplified by the additional anatomical and physiological changes after RYGB
Appendix
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Metadata
Title
Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats
Authors
Florian Seyfried
Marco Bueter
Kerstin Spliethoff
Alexander D. Miras
Kathrin Abegg
Thomas A. Lutz
Carel W. le Roux
Publication date
01-11-2014
Publisher
Springer US
Published in
Obesity Surgery / Issue 11/2014
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1301-3

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