Published in:
01-10-2002 | Adis New Drug Profile
Rosuvastatin
A Viewpoint by Anders C. Olsson
Author:
Anders C. Olsson
Published in:
Drugs
|
Issue 14/2002
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Excerpt
The development of rosuvastatin suggests that this drug may be useful in the treatment and prevention of cardiovascular disease. Rosuvastatin is an appealing statin to the clinician in several ways. It has a marked inhibitory effect on hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase and shows an effective hepatic selectivity, unlike other HMG-CoA reductase inhibitors, which might be of importance with regard to the risk of adverse effects. In addition, it has a low propensity for pharmacokinetic drug interactions and is metabolised very slowly by hepatocytes. …