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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2007

01-11-2007 | Review

Role of T cells and dendritic cells in glomerular immunopathology

Authors: Christian Kurts, Felix Heymann, Veronika Lukacs-Kornek, Peter Boor, Jürgen Floege

Published in: Seminars in Immunopathology | Issue 4/2007

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Abstract

Inappropriate T cell responses cause the four classical types of hypersensitivity immune reactions. All of these can target the kidney and cause distinct forms of glomerulonephritis. CD4+ T cells can mediate glomerular immunopathology by cytokine secretion, by activating effector cells such as macrophages or by inducing auto-antibodies or immune-complexes. Cytotoxic CD8+ T cell responses and failure of regulatory T cells may represent two additional types of anti-renal hypersensitivity. T cell activation is critically dependent on dendritic cells (DC), whose role in renal disease appears to be protective, but underlying mechanisms are largely unknown. In this paper, we summarized mechanistic information from rodent models on the roles of DC and T cells in glomerular immunopathology.
Footnotes
1
The classical definition of type I hypersensitivity encompassed only the early reaction mediated within minutes by preformed IgE. The late allergic phase resulting from Th2 cell-induced cytokines or eosinophil activation originally was classified as a DTH subform (=type IV). For reasons of pathophysiological coherency, we will consider also this response as a manifestation of a Th2-dependent reaction.
 
Literature
1.
Adrogue HE, Borillo J, Torres L, Kale A, Zhou C, Feig D, Merszei J, Johnson R, Lou YH (2007) Coincident activation of Th2 T cells with onset of the disease and differential expression of GRO-gamma in peripheral blood leukocytes in minimal change disease. Am J Nephrol 27:253–261PubMed
2.
Akbari O, DeKruyff RH, Umetsu DT (2001) Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2:725–731PubMed
3.
Amore A, Mazzucco G, Cavallo F, Forni G, Gianoglio B, Motta M, Peruzzi L, Novelli F, Porcellini MG, Cesano G, Coppo R (1996) Adriamycin-induced proteinuria in nude mice: an immune-system-mediated toxic effect. Nephrol Dial Transplant 11:1012–1018PubMed
4.
Anders H, Schlondorff D (2000) Murine models of renal disease: possibilities and problems in studies using mutant mice. Exp Nephrol 8:181–193PubMed
5.
Anders HJ, Banas B, Linde Y, Weller L, Cohen CD, Kretzler M, Martin S, Vielhauer V, Schlondorff D, Grone HJ (2003) Bacterial CpG–DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol 14:317–326PubMed
6.
Anderson CF, Oukka M, Kuchroo VJ, Sacks D (2007) CD4(+)CD25(−)Foxp3(−) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204:285–297PubMed
7.
Ando K, Guidotti LG, Cerny A, Ishikawa T, Chisari FV (1994) CTL access to tissue antigen is restricted in vivo. J Immunol 153:482–488PubMed
8.
Austyn JM, Hankins DF, Larsen CP, Morris PJ, Rao AS, Roake JA (1994) Isolation and characterization of dendritic cells from mouse heart and kidney. J Immunol 152:2401–2410PubMed
9.
Bacchetta R, Gregori S, Roncarolo MG (2005) CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun Rev 4:491–496PubMed
10.
Bagavant H, Tung KS (2005) Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis. J Immunol 175:944–950PubMed
11.
Bagavant H, Deshmukh US, Wang H, Ly T, Fu SM (2006) Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J Immunol 177:8258–8265PubMed
12.
Balomenos D, Rumold R, Theofilopoulos AN (1998) Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101:364–371PubMed
13.
Bell D, Young JW, Banchereau J (1999) Dendritic cells. Adv Immunol 72:255–324PubMed
14.
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–238PubMed
15.
Bettelli E, Oukka M, Kuchroo VK (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8:345–350PubMed
16.
Bevan MJ (2004) Helping the CD8(+) T-cell response. Nat Rev Immunol 4:595–602PubMed
17.
Blank U, Essig M, Scandiuzzi L, Benhamou M, Kanamaru Y (2007) Mast cells and inflammatory kidney disease. Immunol Rev 217:79–95PubMed
18.
Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L (2006) IL-10 regulation of lupus in the NZM2410 murine model. Lab Invest 86:1136–1148PubMed
19.
Bohle A, Strutz F, Muller GA (1994) On the pathogenesis of chronic renal failure in primary glomerulopathies: a view from the interstitium. Exp Nephrol 2:205–210PubMed
20.
Bohle A, Muller GA, Wehrmann M, Mackensen-Haen S, Xiao JC (1996) Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies, and chronic interstitial nephritides. Kidney Int Suppl 54:S2–S9PubMed
21.
Brouwer E, Huitema MG, Klok PA, de Weerd H, Tervaert JW, Weening JJ, Kallenberg CG (1993) Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. J Exp Med 177:905–914PubMed
22.
Burgdorf S, Kautz A, Bohnert V, Knolle PA, Kurts C (2007) Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316:612–616PubMed
23.
Cairns LS, Phelps RG, Bowie L, Hall AM, Saweirs WW, Rees AJ, Barker RN (2003) The fine specificity and cytokine profile of T-helper cells responsive to the alpha3 chain of type IV collagen in Goodpasture’s disease. J Am Soc Nephrol 14:2801–2812PubMed
24.
Cao W, Liu YJ (2007) Innate immune functions of plasmacytoid dendritic cells. Curr Opin Immunol 19:24–30PubMed
25.
Cavallo T (1994) Membranous nephropathy. Insights from Heymann nephritis. Am J Pathol 144:651–658PubMed
26.
Chadban SJ, Atkins RC (2005) Glomerulonephritis. Lancet 365:1797–1806PubMed
27.
Chan OT, Madaio MP, Shlomchik MJ (1999) B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. J Immunol 163:3592–3596PubMed
28.
Clarke BE, Ham KN, Tange JD, Ryan GB (1983) Macrophages and glomerular crescent formation. Studies with rat nephrotoxic nephritis. Pathology (Phila) 15:75–81
29.
Coelho SN, Saleem S, Konieczny BT, Parekh KR, Baddoura FK, Lakkis FG (1997) Immunologic determinants of susceptibility to experimental glomerulonephritis: role of cellular immunity. Kidney Int 51:646–652PubMed
30.
Connolly K, Roubinian JR, Wofsy D (1992) Development of murine lupus in CD4-depleted NZB/NZW mice. Sustained inhibition of residual CD4+ T cells is required to suppress autoimmunity. J Immunol 149:3083–3088PubMed
31.
Cook HT, Singh SJ, Wembridge DE, Smith J, Tam FW, Pusey CD (1999) Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats. Kidney Int 55:1319–1326PubMed
32.
Coombes JL, Robinson NJ, Maloy KJ, Uhlig HH, Powrie F (2005) Regulatory T cells and intestinal homeostasis. Immunol Rev 204:184–194PubMed
33.
Couser WG, Nangaku M (2006) Cellular and molecular biology of membranous nephropathy. J Nephrol 19:699–705PubMed
34.
Couzi L, Merville P, Deminiere C, Moreau JF, Combe C, Pellegrin JL, Viallard JF, Blanco P (2007) Predominance of CD8+ T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritis. Arthritis Rheum 56:2362–2370PubMed
35.
Cunningham MA, Huang XR, Dowling JP, Tipping PG, Holdsworth SR (1999) Prominence of cell-mediated immunity effectors in “pauci-immune” glomerulonephritis. J Am Soc Nephrol 10:499–506PubMed
36.
Davey GM, Kurts C, Miller JF, Bouillet P, Strasser A, Brooks AG, Carbone FR, Heath WR (2002) Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med 196:947–955PubMed
37.
de Heer E, Daha MR, Burgers J, van Es LA (1986) Reestablishment of self tolerance by suppressor T-cells after active Heymann’s nephritis. Cell Immunol 98:28–33PubMed
38.
Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A (1994) An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4–8− T cells. J Exp Med 180:1171–1176PubMed
39.
den Haan JM, Lehar SM, Bevan MJ (2000) CD8(+) but not CD8(−) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 192:1685–1696PubMed
40.
DiLorenzo TP, Serreze DV (2005) The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice. Immunological reviews 204:250–263PubMed
41.
Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA, Griffin MD (2005) Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney. Kidney Int 68:1096–1108PubMed
42.
Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA, Griffin MD (2007) Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 71:619–628PubMed
43.
Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC (2007) Differential antigen processing by dendritic cell subsets in vivo. Science 315:107–111PubMed
44.
Duffield JS, Tipping PG, Kipari T, Cailhier JF, Clay S, Lang R, Bonventre JV, Hughes J (2005) Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Pathol 167:1207–1219PubMed
45.
Falk MC, Ng G, Zhang GY, Fanning GC, Roy LP, Bannister KM, Thomas AC, Clarkson AR, Woodroffe AJ, Knight JF (1995) Infiltration of the kidney by alpha beta and gamma delta T cells: effect on progression in IgA nephropathy. Kidney Int 47:177–185PubMed
46.
Faria AM, Weiner HL (2006) Oral tolerance and TGF-beta-producing cells. Inflam Allergy Drug Targets 5:179–190
47.
Floege J (2003) Evidence-based recommendations for immunosuppression in IgA nephropathy: handle with caution. Nephrol Dial Transplant 18:241–245PubMed
48.
Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4:330–336PubMed
49.
50.
Fujii T, Hamano Y, Ueda S, Akikusa B, Yamasaki S, Ogawa M, Saisho H, Verbeek JS, Taki S, Saito T (2003) Predominant role of FcgammaRIII in the induction of accelerated nephrotoxic glomerulonephritis. Kidney Int 64:1406–1416PubMed
51.
Fujinaka H, Nameta M, Kovalenko P, Matsuki A, Kato N, Nishimoto G, Yoshida Y, Yaoita E, Naito M, Kihara I, Tomizawa S, Yamamoto T (2007) Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis. J Nephrol 20:357–363PubMed
52.
Gell PG, Coombs RR (1963) The classification of allergic reactions underlying disease. In: Coombs RRA, Gell PGH (eds) Clinical aspects of immunology. Blackwell Science, Philadelphia, PA, pp 317–320
53.
Ghielli M, Verstrepen WA, Dauwe S, Nouwen EJ, De Broe ME (1997) Selective depletion of CD8-positive leukocytes does not alter mercuric chloride induced acute renal failure in the rat. Exp Nephrol 5:69–81PubMed
54.
Godfrey DI, Kronenberg M (2004) Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 114:1379–1388PubMed
55.
Groggel GC, Terreros DA (1990) Role of the terminal complement pathway in accelerated autologous anti-glomerular basement membrane nephritis. Am J Pathol 136:533–540PubMed
56.
Groux H, O’Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737–742PubMed
57.
Haas C, Ryffel B, Le Hir M (1998) IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol 160:3713–3718PubMed
58.
Hamar P, Peti-Peterdi J, Razga Z, Kovacs G, Heemann U, Rosivall L (1999) Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney. J Am Soc Nephrol 10(Suppl 11):S234–S238PubMed
59.
Hanninen A, Hamilton-Williams E, Kurts C (2003) Development of new strategies to prevent type 1 diabetes: the role of animal models. Ann Med 35:546–563PubMed
60.
Hawrylowicz CM, O’Garra A (2005) Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 5:271–283PubMed
61.
Hayday A, Tigelaar R (2003) Immunoregulation in the tissues by gammadelta T cells. Nature Rev 3:233–242CrossRef
62.
Hiromura K, Kurosawa M, Yano S, Naruse T (1998) Tubulointerstitial mast cell infiltration in glomerulonephritis. Am J Kidney Dis 32:593–599PubMed
63.
Hochegger K, Siebenhaar F, Vielhauer V, Heininger D, Mayadas TN, Mayer G, Maurer M, Rosenkranz AR (2005) Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritis. Eur J Immunol 35:3074–3082PubMed
64.
Hochegger K, Wolf D, Rosenkranz AR (2005) CD4CD25 regulatory T cells: a new treatment option in glomerulonephritis. Kidney Int 68:1898–1899PubMed
65.
Hopfer H, Maron R, Butzmann U, Helmchen U, Weiner HL, Kalluri R (2003) The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J 17:860–868PubMed
66.
Huang XR, Holdsworth SR, Tipping PG (1994) Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation. Kidney Int 46:69–78PubMed
67.
Huang XR, Holdsworth SR, Tipping PG (1997) Th2 responses induce humorally mediated injury in experimental anti-glomerular basement membrane glomerulonephritis. J Am Soc Nephrol 8:1101–1108PubMed
68.
Hume DA, Gordon S (1983) Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. J Exp Med 157:1704–1709PubMed
69.
Hume DA, Ross IL, Himes SR, Sasmono RT, Wells CA, Ravasi T (2002) The mononuclear phagocyte system revisited. J Leukoc Biol 72:621–627PubMed
70.
Ikezumi Y, Kawachi H, Toyabe S, Uchiyama M, Shimizu F (2000) An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis. Kidney Int 58:100–114PubMed
71.
Ikezumi Y, Kanno K, Karasawa T, Han GD, Ito Y, Koike H, Toyabe S, Uchiyama M, Shimizu F, Kawachi H (2004) The role of lymphocytes in the experimental progressive glomerulonephritis. Kidney Int 66:1036–1048PubMed
72.
Jabs DA, Burek CL, Hu Q, Kuppers RC, Lee B, Prendergast RA (1992) Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice. Cell Immunol 141:496–507PubMed
73.
Jacob CO, Pricop L, Putterman C, Koss MN, Liu Y, Kollaros M, Bixler SA, Ambrose CM, Scott ML, Stohl W (2006) Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF. J Immunol 177:2671–2680PubMed
74.
Janeway CA, Travers P, Walport MJ, Shlomchik MJ (2004) Immunobiology, 6th edn. Garland Science, New York, Tokyo
75.
Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A (2007) Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204:273–283PubMed
76.
Janssen U, Ostendorf T, Gaertner S, Eitner F, Hedrich HJ, Assmann KJ, Floege J (1998) Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice. J Am Soc Nephrol 9:1805–1814PubMed
77.
Jennette JC, Xiao H, Falk RJ (2006) Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 17:1235–1242PubMed
78.
Johansen PB (1981) Doxorubicin pharmacokinetics after intravenous and intraperitoneal administration in the nude mouse. Cancer Chemother Pharmacol 5:267–270PubMed
79.
Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17:211–220PubMed
80.
Kaissling B, Le Hir M (1994) Characterization and distribution of interstitial cell types in the renal cortex of rats. Kidney Int 45:709–720PubMed
81.
Kaissling B, Hegyi I, Loffing J, Le Hir M (1996) Morphology of interstitial cells in the healthy kidney. Anat Embryol (Berl) 193:303–318
82.
Kallenberg CG (2007) Antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. Curr Opin Rheumatol 19:17–24PubMed
83.
Kalluri R, Danoff TM, Okada H, Neilson EG (1997) Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J Clin Invest 100:2263–2275PubMed
84.
Kaneko Y, Nimmerjahn F, Madaio MP, Ravetch JV (2006) Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. J Exp Med 203:789–797PubMed
85.
Kang HK, Datta SK (2006) Regulatory T cells in lupus. Int Rev Immunol 25:5–25PubMed
86.
Karkar AM, Rees AJ (1997) Influence of endotoxin contamination on anti-GBM antibody induced glomerular injury in rats. Kidney Int 52:1579–1583PubMed
87.
Kawasaki K, Yaoita E, Yamamoto T, Kihara I (1992) Depletion of CD8 positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int 41:1517–1526PubMed
88.
Kelley VR, Singer GG (1993) The antigen presentation function of renal tubular epithelial cells. Exp Nephrol 1:102–111PubMed
89.
Kikawada E, Lenda DM, Kelley VR (2003) IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 170:3915–3925PubMed
90.
Kinjo Y, Wu D, Kim G, Xing GW, Poles MA, Ho DD, Tsuji M, Kawahara K, Wong CH, Kronenberg M (2005) Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434:520–525PubMed
91.
Kitching AR, Tipping PG, Huang XR, Mutch DA, Holdsworth SR (1997) Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. Kidney Int 52:52–59PubMed
92.
Kitching AR, Holdsworth SR, Tipping PG (1999) IFN-gamma mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis. J Am Soc Nephrol 10:752–759PubMed
93.
Kitching AR, Tipping PG, Timoshanko JR, Holdsworth SR (2000) Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. Kidney Int 57:518–525PubMed
94.
Kitching AR, Turner AL, Semple T, Li M, Edgtton KL, Wilson GR, Timoshanko JR, Hudson BG, Holdsworth SR (2004) Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J Am Soc Nephrol 15:1764–1774PubMed
95.
Kitching AR, Turner AL, Wilson GR, Edgtton KL, Tipping PG, Holdsworth SR (2004) Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis. J Am Soc Nephrol 15:2373–2382PubMed
96.
Koren G (1989) The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance. Med Toxicol Adverse Drug Exp 4:59–72PubMed
97.
Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484–487PubMed
98.
Koyama A, Fujisaki M, Kobayashi M, Igarashi M, Narita M (1991) A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 40:453–460PubMed
99.
Kreuwel HT, Aung S, Silao C, Sherman LA (2002) Memory CD8(+) T cells undergo peripheral tolerance. Immunity 17:73–81PubMed
100.
Kronenberg M (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 23:877–900PubMed
101.
Krüger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Müller-Newen G, Floege J, Kurts C (2004) Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 15:613–621PubMed
102.
Kurts C, Heath WR, Carbone FR, Allison J, Miller JF, Kosaka H (1996) Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med 184:923–930PubMed
103.
Kurts C, Carbone FR, Barnden M, Blanas E, Allison J, Heath WR, Miller JF (1997) CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med 186:2057–2062PubMed
104.
Kurts C, Kosaka H, Carbone FR, Miller JF, Heath WR (1997) Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 186:239–245PubMed
105.
Kurts C, Heath WR, Kosaka H, Miller JF, Carbone FR (1998) The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med 188:415–420PubMed
106.
Kurts C, Cannarile M, Klebba I, Brocker T (2001) Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo. J Immunol 166:1439–1442PubMed
107.
Kurts C, Klebba I, Davey GM, Koch KM, Miller JF, Heath WR, Floege J (2001) Kidney protection against autoreactive CD8(+) T cells distinct from immunoprivilege and sequestration. Kidney Int 60:664–671PubMed
108.
Kurts C (2006) Dendritic cells: not just another cell type in the kidney, but a complex immune sentinel network. Kidney international 70:412–414PubMed
109.
Lai KW, Wei CL, Tan LK, Tan PH, Chiang GS, Lee CG, Jordan SC, Yap HK (2007) Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol 18:1476–1485PubMed
110.
Lan HY, Nikolic-Paterson DJ, Atkins RC (1992) Involvement of activated periglomerular leukocytes in the rupture of Bowman’s capsule and glomerular crescent progression in experimental glomerulonephritis. Lab Invest 67:743–751PubMed
111.
Lawson BR, Koundouris SI, Barnhouse M, Dummer W, Baccala R, Kono DH, Theofilopoulos AN (2001) The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus. J Immunol 167:2354–2360PubMed
112.
Lee VW, Wang Y, Qin X, Zheng G, Mahajan D, Coombes J, Rangan G, Alexander SI, Harris DC (2006) Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrol Dial Transplant 21:3293–3298PubMed
113.
Li S, Kurts C, Kontgen F, Holdsworth SR, Tipping PG (1998) Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis. J Exp Med 188:597–602PubMed
114.
Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303:1662–1665PubMed
115.
Mahajan D, Wang Y, Qin X, Zheng G, Wang YM, Alexander SI, Harris DC (2006) CD4+ CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease. J Am Soc Nephrol 17:2731–2741PubMed
116.
Markovic-Lipkovski J, Muller CA, Risler T, Bohle A, Muller GA (1990) Association of glomerular and interstitial mononuclear leukocytes with different forms of glomerulonephritis. Nephrol Dial Transplant 5:10–17PubMed
117.
Masutani K, Akahoshi M, Tsuruya K, Tokumoto M, Ninomiya T, Kohsaka T, Fukuda K, Kanai H, Nakashima H, Otsuka T, Hirakata H (2001) Predominance of Th1 immune response in diffuse proliferative lupus nephritis. Arthritis Rheum 44:2097–2106PubMed
118.
Mattner J, Debord KL, Ismail N, Goff RD, Cantu C 3rd, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A (2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525–529PubMed
119.
Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255–258PubMed
120.
Meyers CM, Kelly CJ (1991) Effector mechanisms in organ-specific autoimmunity. I. Characterization of a CD8+ T cell line that mediates murine interstitial nephritis. J Clin Invest 88:408–416PubMed
121.
Mieza MA, Itoh T, Cui JQ, Makino Y, Kawano T, Tsuchida K, Koike T, Shirai T, Yagita H, Matsuzawa A, Koseki H, Taniguchi M (1996) Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice. J Immunol 156:4035–4040PubMed
122.
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317:256–260PubMed
123.
Munz C, Steinman RM, Fujii S (2005) Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med 202:203–207PubMed
124.
Nakamura T, Sonoda KH, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein J (2003) CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171:1266–1271PubMed
125.
Neilson EG (1993) The nephritogenic T lymphocyte response in interstitial nephritis. Semin Nephrol 13:496–502PubMed
126.
Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF (2007) IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol 37:1809–1816PubMed
127.
Nogaki F, Muso E, Kobayashi I, Kusano H, Shirakawa K, Kamata T, Oyama A, Ono T, Miyawaki S, Yoshida H, Sasayama S (2000) Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition. Nephrol Dial Transplant 15:1146–1154PubMed
128.
O’Garra A, Vieira PL, Vieira P, Goldfeld AE (2004) IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest 114:1372–1378PubMed
129.
Ohmuro H, Tomino Y, Koide H (1994) Effect of monoclonal antibody CD4 on expression of intercellular adhesion molecule 1 in renal tissues of ddY mice: a spontaneous animal model of IgA nephropathy. Am J Nephrol 14:136–141PubMed
130.
Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner JE, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RA (2007) Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. J Am Soc Nephrol 18:2071–2084PubMed
131.
Pasare C, Medzhitov R (2003) Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033–1036PubMed
132.
Penny MJ, Boyd RA, Hall BM (1997) Role of T cells in the mediation of Heymann nephritis. ii. Identification of Th1 and cytotoxic cells in glomeruli. Kidney Int 51:1059–1068PubMed
133.
Penny MJ, Boyd RA, Hall BM (1998) Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis. J Exp Med 188:1775–1784PubMed
134.
Quiza CG, Leenaerts PL, Hall BM (1991) Induction of unresponsiveness to Heymann’s nephritis: inhibited by monoclonal antibody to CD4 but not to CD8. Cell Immunol 133:456–467PubMed
135.
Quiza CG, Leenaerts PL, Hall BM (1992) The role of T cells in the mediation of glomerular injury in Heymann’s nephritis in the rat. Int Immunol 4:423–432PubMed
136.
Radeke HH, Emmendorffer A, Uciechowski P, von der Ohe J, Schwinzer B, Resch K (1994) Activation of autoreactive T-lymphocytes by cultured syngeneic glomerular mesangial cells. Kidney Int 45:763–774PubMed
137.
Randolph GJ, Angeli V, Swartz MA (2005) Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 5:617–628PubMed
138.
Reinhardt RL, Khoruts A, Merica R, Zell T, Jenkins MK (2001) Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101–105PubMed
139.
Reininger L, Winkler TH, Kalberer CP, Jourdan M, Melchers F, Rolink AG (1996) Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB × NZW)F1 mice. J Exp Med 184:853–861PubMed
140.
Reis e Sousa C (2004) Activation of dendritic cells: translating innate into adaptive immunity. Curr Opin Immunol 16:21–25PubMed
141.
Reynolds J, Sallie BA, Syrganis C, Pusey CD (1993) The role of T-helper lymphocytes in priming for experimental autoimmune glomerulonephritis in the BN rat. J Autoimmun 6:571–585PubMed
142.
Reynolds J, Pusey CD (1994) In vivo treatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephritis in the BN rat. Clin Exp Immunol 95:122–127PubMedCrossRef
143.
Reynolds J, Pusey CD (2001) Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. J Am Soc Nephrol 12:61–70PubMed
144.
Reynolds J, Norgan VA, Bhambra U, Smith J, Cook HT, Pusey CD (2002) Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 13:359–369PubMed
145.
Reynolds J, Prodromidi EI, Juggapah JK, Abbott DS, Holthaus KA, Kalluri R, Pusey CD (2005) Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. J Am Soc Nephrol 16:1350–1359PubMed
146.
Ring GH, Dai Z, Saleem S, Baddoura FK, Lakkis FG (1999) Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice. J Immunol 163:2243–2248PubMed
147.
Roake JA, Rao AS, Morris PJ, Larsen CP, Hankins DF, Austyn JM (1995) Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 181:2237–2247PubMed
148.
Robertson J, Wu J, Arends J, Glass W 2nd, Southwood S, Sette A, Lou YH (2005) Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis. Kidney Int 68:1061–1070PubMed
149.
Saito T, Atkins RC (1990) Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis. Kidney Int 37:1076–1083PubMed
150.
Sakaguchi S (2006) Regulatory T cells. Semin Immunopathol 28:1–2
151.
Salama AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lechler RI, Pusey CD, Lightstone L (2003) Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture’s (anti-GBM) disease. Kidney Int 64:1685–1694PubMed
152.
Santiago ML, Fossati L, Jacquet C, Muller W, Izui S, Reininger L (1997) Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 185:65–70PubMed
153.
Savignac M, Gomes B, Gallard A, Narbonnet S, Moreau M, Leclerc C, Paulet P, Mariame B, Druet P, Saoudi A, Fournie GJ, Guery JC, Pelletier L (2004) Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders. J Immunol 172:5206–5212PubMed
154.
Schatzmann U, Haas C, Le Hir M (1999) A Th1 response is essential for induction of crescentic glomerulonephritis in mice. Kidney Blood Press Res 22:135–139PubMed
155.
Scholz J, Lukacs-Kornek V, Engel D, Specht S, Kiss E, Eitner F, Floege J, Groene H, Kurts C (2008) Kidney dendritic cells stimulate IL-10 production in nephrotoxic nephritis and attenuate disease. J Am Soc Nephrol (in press)
156.
Schulte T, Kurrle R, Rollinghoff M, Gessner A (1997) Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. J Exp Med 186:1419–1429PubMed
157.
Schwarting A, Moore K, Wada T, Tesch G, Yoon HJ, Kelley VR (1998) IFN-gamma limits macrophage expansion in MRL-Fas(lpr) autoimmune interstitial nephritis: a negative regulatory pathway. J Immunol 160:4074–4081PubMed
158.
Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM (2006) The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev 212:60–73PubMed
159.
Shimamine R, Shibata R, Ozono Y, Harada T, Taguchi T, Hara K, Kono S (1998) Anti-CD8 monoclonal antibody protects against spontaneous IgA nephropathy in ddY mice. Nephron 78:310–318PubMed
160.
Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, Akahoshi M, Katafuchi R, Hirakata H, Harada M, Hamano S, Nakashima H, Yoshida H (2005) Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol 175:7185–7192PubMed
161.
Shortman K, Naik SH (2007) Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7:19–30PubMed
162.
Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, Joyce S, Singh RR, Van Kaer L (2005) The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur J Immunol 35:1143–1154PubMed
163.
Singh RR, Saxena V, Zang S, Li L, Finkelman FD, Witte DP, Jacob CO (2003) Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 170:4818–4825PubMed
164.
Spicer ST, Ha H, Boyd RA, He XY, Carter N, Tran G, Penny MJ, Hodgkinson SJ, Hall BM (2001) Il-4 therapy prevents the development of proteinuria in active Heymann nephritis by inhibition of Tc1 cells. J Immunol 167:3725–3733PubMed
165.
Spicer ST, Tran GT, Killingsworth MC, Carter N, Power DA, Paizis K, Boyd R, Hodgkinson SJ, Hall BM (2007) Induction of passive Heymann nephritis in complement component 6-deficient PVG rats. J Immunol 179:172–178PubMed
166.
Steinman L, Zamvil SS (2006) How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60:12–21PubMed
167.
Steinman RM, Hawiger D, Liu K, Bonifaz L, Bonnyay D, Mahnke K, Iyoda T, Ravetch J, Dhodapkar M, Inaba K, Nussenzweig M (2003) Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci 987:15–25PubMed
168.
Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21:685–711PubMed
169.
Susani M, Schulze M, Exner M, Kerjaschki D (1994) Antibodies to glycolipids activate complement and promote proteinuria in passive Heymann nephritis. Am J Pathol 144:807–819PubMed
170.
Suss G, Shortman K (1996) A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis. J Exp Med 183:1789–1796PubMed
171.
Suzuki H, Suzuki Y, Aizawa M, Yamanaka T, Kihara M, Pang H, Horikoshi S, Tomino Y (2007) Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells. Kidney Int 72:319–327PubMed
172.
Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S (1996) Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97:1597–1604PubMedCrossRef
173.
Takeda K, Dennert G (1993) The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J Exp Med 177:155–164PubMed
174.
Tam FW, Smith J, Karkar AM, Pusey CD, Rees AJ (1997) Interleukin-4 ameliorates experimental glomerulonephritis and up-regulates glomerular gene expression of IL-1 decoy receptor. Kidney Int 52:1224–1231PubMed
175.
Tarzi RM, Davies KA, Claassens JW, Verbeek JS, Walport MJ, Cook HT (2003) Both Fcgamma receptor I and Fcgamma receptor III mediate disease in accelerated nephrotoxic nephritis. Am J Pathol 162:1677–1683PubMed
176.
Tato CM, O’Shea JJ (2006) Immunology: what does it mean to be just 17? Nature 441:166–168PubMed
177.
Timoshanko JR, Kitching AR, Holdsworth SR, Tipping PG (2001) Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis. J Am Soc Nephrol 12:464–471PubMed
178.
Timoshanko JR, Holdsworth SR, Kitching AR, Tipping PG (2002) IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol 168:4135–4141PubMed
179.
Timoshanko JR, Sedgwick JD, Holdsworth SR, Tipping PG (2003) Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. J Am Soc Nephrol 14:1785–1793PubMed
180.
Timoshanko JR, Kitching R, Semple TJ, Tipping PG, Holdsworth SR (2006) A pathogenetic role for mast cells in experimental crescentic glomerulonephritis. J Am Soc Nephrol 17:150–159PubMed
181.
Tipping PG, Kitching AR, Huang XR, Mutch DA, Holdsworth SR (1997) Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis. Eur J Immunol 27:530–537PubMed
182.
Tipping PG, Huang XR, Qi M, Van GY, Tang WW (1998) Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. Am J Pathol 152:1541–1548PubMed
183.
Tipping PG, Holdsworth SR (2006) T cells in crescentic glomerulonephritis. J Am Soc Nephrol 17:1253–1263PubMed
184.
Tomino Y, Shimizu M, Koide H, Abe M, Shirai T (1993) Effect of monoclonal antibody CD4 on glomerulonephritis of ddY mice, a spontaneous animal model of IgA nephropathy. Am J Kidney Dis 21:427–432PubMed
185.
Toth T, Toth-Jakatics R, Jimi S, Ihara M, Urata H, Takebayashi S (1999) Mast cells in rapidly progressive glomerulonephritis. J Am Soc Nephrol 10:1498–1505PubMed
186.
Trinchieri G (2007) Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med 204:239–243PubMed
187.
Turnberg D, Botto M, Warren J, Morgan BP, Walport MJ, Cook HT (2003) CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice. J Am Soc Nephrol 14:2271–2279PubMed
188.
van Alderwegen IE, Bruijn JA, de Heer E (1997) T cell subsets in immunologically-mediated glomerulonephritis. Histol Histopathol 12:241–250PubMed
189.
van der Vliet HJ, von Blomberg BM, Nishi N, Reijm M, Voskuyl AE, van Bodegraven AA, Polman CH, Rustemeyer T, Lips P, van den Eertwegh AJ, Giaccone G, Scheper RJ, Pinedo HM (2001) Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 100:144–148PubMed
190.
Van Kaer L (2007) NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol 19:354–364PubMed
191.
Vella AT, McCormack JE, Linsley PS, Kappler JW, Marrack P (1995) Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261–270PubMed
192.
Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K (2000) Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Eur J Immunol 30:1182–1190PubMed
193.
Walters G, Wu H, Knight JF (2001) Glomerular T cells in Heymann nephritis. Clin Exp Immunol 126:319–325PubMed
194.
Walters G, Habib AM, Reynolds J, Wu H, Knight JF, Pusey CD (2004) Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis. Nephron 98:e71–e81PubMed
195.
Wan S, Xia C, Morel L (2007) IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+ CD25+ T cell regulatory functions. J Immunol 178:271–279PubMed
196.
Wang Y, Feng X, Bao S, Yi S, Kairaitis L, Tay YC, Rangan GK, Harris DC (2001) Depletion of CD4(+) T cells aggravates glomerular and interstitial injury in murine adriamycin nephropathy. Kidney Int 59:975–984PubMed
197.
Wang Y, Wang YP, Tay YC, Harris DC (2001) Role of CD8(+) cells in the progression of murine adriamycin nephropathy. Kidney Int 59:941–949PubMed
198.
Wang YM, Zhang GY, Wang Y, Hu M, Wu H, Watson D, Hori S, Alexander IE, Harris DC, Alexander SI (2006) Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. J Am Soc Nephrol 17:697–706PubMed
199.
Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821–852PubMed
200.
Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA (1994) Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12:809–837PubMed
201.
Wolf D, Hochegger K, Wolf AM, Rumpold HF, Gastl G, Tilg H, Mayer G, Gunsilius E, Rosenkranz AR (2005) CD4+ CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice. J Am Soc Nephrol 16:1360–1370PubMed
202.
Woltman AM, de Fijter JW, Zuidwijk K, Vlug AG, Bajema IM, van der Kooij SW, van Ham V, van Kooten C (2007) Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int 71:1001–1008PubMed
203.
Wu H, Knight JF, Alexander SI (2004) Regulatory gamma delta T cells in Heymann nephritis express an invariant Vgamma6/Vdelta1 with a canonical CDR3 sequence. Eur J Immunol 34:2322–2330PubMed
204.
Wu H, Wang YM, Wang Y, Hu M, Zhang GY, Knight JF, Harris DC, Alexander SI (2007) Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. J Am Soc Nephrol 18:1180–1189PubMed
205.
Wu J, Hicks J, Borillo J, Glass WF 2nd, Lou YH (2002) CD4(+) T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 109:517–524PubMed
206.
Yang JQ, Saxena V, Xu H, Van Kaer L, Wang CR, Singh RR (2003) Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J Immunol 171:4439–4446PubMed
207.
Yang JQ, Chun T, Liu H, Hong S, Bui H, Van Kaer L, Wang CR, Singh RR (2004) CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur J Immunol 34:1723–1732PubMed
208.
Yang JQ, Wen X, Liu H, Folayan G, Dong X, Zhou M, Van Kaer L, Singh RR (2007) Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum 56:1219–1233PubMed
209.
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J (2002) IL-10 regulates murine lupus. J Immunol 169:2148–2155PubMed
210.
Zakheim B, McCafferty E, Phillips SM, Clayman M, Neilson EG (1984) Murine interstitial nephritis. II. The adoptive transfer of disease with immune T lymphocytes produces a phenotypically complex interstitial lesion. J Immunol 133:234–239PubMed
211.
Zeng D, Lee MK, Tung J, Brendolan A, Strober S (2000) Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J Immunol 164:5000–5004PubMed
212.
Zhou D, Mattner J, Cantu C 3rd, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L, Bendelac A (2004) Lysosomal glycosphingolipid recognition by NKT cells. Science 306:1786–1789PubMed
Metadata
Title
Role of T cells and dendritic cells in glomerular immunopathology
Authors
Christian Kurts
Felix Heymann
Veronika Lukacs-Kornek
Peter Boor
Jürgen Floege
Publication date
01-11-2007
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2007
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-007-0096-x

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