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01-10-2013 | Review

Role of neutrophils in systemic autoimmune diseases

Author: Mariana J Kaplan

Published in: Arthritis Research & Therapy | Issue 5/2013

Abstract

Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles that neutrophils and aberrant neutrophil cell death play in the pathogenesis of various systemic autoimmune diseases, including systemic lupus erythematosus, small vessel vasculitis and rheumatoid arthritis.

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Title: Role of neutrophils in systemic autoimmune diseases
Author: Mariana J Kaplan
Publication date: 01-10-2013
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 5/2013
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar4325

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