Published in:
Open Access
01-05-2014 | Oral presentation
Role of myeloid derived suppressor cells in tuberculosis infection and disease
Authors:
Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V Banurekha, Mohideen S Jawahar, Thomas B Nutman, Subash Babu
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
Login to get access
Excerpt
Mycobacterium tuberculosis infects 2 billion people worldwide, 90% of infected individuals are able to resist overt disease development and manifest only latent infection. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, immature granulocytes, macrophages, and dendritic cells at different stages of differentiation. These cells have the capacity to suppress activities of adaptive immune response mediated by CD4+ and CD8+ T cells. …