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Clinical Reviews in Allergy & Immunology

Published in:

01-12-2011

Role of Dendritic Cells in Atopic Dermatitis: An Update

Authors: Thomas Bieber, Natalija Novak, Nadine Herrman, Susanne Koch

Published in: Clinical Reviews in Allergy & Immunology | Issue 3/2011

Abstract

Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.

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Title: Role of Dendritic Cells in Atopic Dermatitis: An Update
Authors: Thomas Bieber
Natalija Novak
Nadine Herrman
Susanne Koch
Publication date: 01-12-2011
Publisher: Humana Press Inc
Published in: Clinical Reviews in Allergy & Immunology / Issue 3/2011
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-010-8224-0

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