Published in:
08-02-2024 | Editorial
Role of combined aerobic and resistance exercise in liver cirrhosis
Authors:
Tadashi Namisaki, Shinya Sato, Hitoshi Yoshiji
Published in:
Journal of Gastroenterology
|
Issue 4/2024
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Excerpt
In this issue, Kawaguchi et al. investigated the effects of aerobic and resistance exercise on hepatic complications in patients with liver cirrhosis (LC) of different etiologies [
1]. A meta-analysis of 11 randomized controlled trials (RCTs) found that exercise has a significant effect on the incidence of serious events including liver function capacity, or patient-reported outcomes. Moreover, resistance exercise reduced the incidence of serious events, including liver failure, hepatocellular carcinoma (HCC), and infection, by reducing sarcopenia in patients with LC. Sarcopenia is a risk factor for serious events [
2,
3] in patients with LC, worsening with decreased hepatic synthetic capacity [
4]. Several RCTs have demonstrated that 8–14 weeks of exercise improved sarcopenia in patients with Child–Pugh class A (CPA) and Child–Pugh class B (CPB) LC in the Evidence-Based Clinical Practice Guidelines for Liver Cirrhosis 2020 [
5‐
8]. …
